Viola Nordström
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View article: Gangliosides modulate insulin secretion by pancreatic beta cells under glucose stress
Gangliosides modulate insulin secretion by pancreatic beta cells under glucose stress Open
In pancreatic beta cells, the entry of glucose and downstream signaling for insulin release is regulated by the glucose transporter 2 (Glut2) in rodents. Dysfunction of the insulin-signaling cascade may lead to diabetes mellitus. Gangliosi…
View article: Renal globotriaosylceramide facilitates tubular albumin absorption and its inhibition protects against acute kidney injury
Renal globotriaosylceramide facilitates tubular albumin absorption and its inhibition protects against acute kidney injury Open
To elucidate the physiologic function of renal globotriaosylceramide (Gb3/CD77), which up-to-date has been associated exclusively with Shiga toxin binding, we have analyzed renal function in Gb3-deficient mice. Gb3 synthase KO (Gb3S-/-) mi…
View article: Deletion of Specific Sphingolipids in Distinct Neurons Improves Spatial Memory in a Mouse Model of Alzheimer’s Disease
Deletion of Specific Sphingolipids in Distinct Neurons Improves Spatial Memory in a Mouse Model of Alzheimer’s Disease Open
Alzheimer's disease (AD) is characterized by progressive neurodegeneration and a concomitant loss of synapses and cognitive abilities. Recently, we have proposed that an alteration of neuronal membrane lipid microdomains increases neuronal…
View article: Lipid microdomain modification sustains neuronal viability in models of Alzheimer’s disease
Lipid microdomain modification sustains neuronal viability in models of Alzheimer’s disease Open
Decreased neuronal insulin receptor (IR) signaling in Alzheimer's disease is suggested to contribute to synaptic loss and neurodegeneration. This work shows that alteration of membrane microdomains increases IR levels and signaling, as wel…
View article: Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis
Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis Open
Renal tubular atrophy and interstitial fibrosis are common hallmarks of etiologically different progressive chronic kidney diseases (CKD) that eventually result in organ failure. Even though these pathological manifestations constitute a m…