Viola Puddinu
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View article: GSDMD is associated with survival in human breast cancer but does not impact anti-tumor immunity in a mouse breast cancer model
GSDMD is associated with survival in human breast cancer but does not impact anti-tumor immunity in a mouse breast cancer model Open
Inflammation plays a pivotal role in cancer development, with chronic inflammation promoting tumor progression and treatment resistance, whereas acute inflammatory responses contribute to protective anti-tumor immunity. Gasdermin D (GSDMD)…
View article: PEGylated Gold Nanoparticles Target Age-Associated B Cells In Vivo
PEGylated Gold Nanoparticles Target Age-Associated B Cells In Vivo Open
Engineered gold nanoparticles (GNPs) have become a useful tool in various therapeutic and diagnostic applications. Uncertainty remains regarding the possible impact of GNPs on the immune system. In this regard, we investigated the interact…
View article: HMGB1 promotes CXCL12‐dependent egress of murine B cells from Peyer's patches in homeostasis
HMGB1 promotes CXCL12‐dependent egress of murine B cells from Peyer's patches in homeostasis Open
High mobility group box‐1 protein (HMGB1) is an alarmin that, once released, promotes inflammatory responses, alone and as a complex with the chemokine CXCL12. Here, we report that the HMGB1–CXCL12 complex plays an essential role also in h…
View article: NAB2 is a novel immune stimulator of MDA-5 that promotes a strong type I interferon response
NAB2 is a novel immune stimulator of MDA-5 that promotes a strong type I interferon response Open
Novel adjuvants are needed to increase the efficacy of vaccine formulations and immune therapies for cancer and chronic infections. In particular, adjuvants that promote a strong type I IFN response are required, since this cytokine is cru…
View article: ACKR3 expression on diffuse large B cell lymphoma is required for tumor spreading and tissue infiltration
ACKR3 expression on diffuse large B cell lymphoma is required for tumor spreading and tissue infiltration Open
Diffuse large B cell lymphoma (DLBCL) is the most frequent lymphoma accounting for more than the 30% of the cases. Involvement of extranodal sites, such as bone marrow and central nervous system, is associated with poor prognosis. A contri…