Vipendra Kumar Singh
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View article: A multi-target computational approach to target the polycystic ovary syndrome receptors using natural compounds
A multi-target computational approach to target the polycystic ovary syndrome receptors using natural compounds Open
Background Polycystic ovary syndrome (PCOS) is a prevalent endocrinopathy characterized by excess androgen production and associated metabolic disturbances. Although several synthetic drugs, such as hypoglycemic and ovulation-inducing agen…
View article: Signal Peptide of Human Serum Albumin (residues 1–18) Forms Amyloid-like Aggregates
Signal Peptide of Human Serum Albumin (residues 1–18) Forms Amyloid-like Aggregates Open
Signal peptides (SPs) are essential tools for sorting or translocating synthesized proteins. However, except for a few examples, their studies in isolation are quite limited. Here, we asked a question about the aggregation propensity of si…
View article: Targeting matrix metalloproteinase-9 (MMP9) in prostate cancer: a computational study on natural product-derived novel potential inhibitors
Targeting matrix metalloproteinase-9 (MMP9) in prostate cancer: a computational study on natural product-derived novel potential inhibitors Open
Background Prostate cancer is one of the prime causes of death in men worldwide; the number of patients has increased every year despite significant efforts and outlay in the research of prostate cancer. Identifying new natural targets for…
View article: Signal Peptide of Human Serum Albumin (residues 1-18) Forms Amyloid-like Aggregates
Signal Peptide of Human Serum Albumin (residues 1-18) Forms Amyloid-like Aggregates Open
Signal peptides (SPs) are essential tools in sorting or translocating the synthesized proteins. However, except few examples, their studies in isolation are quite limited. Here we asked a question of the aggregation propensity of signal pe…
View article: The multi-protein targeting potential of bioactive syringin in inflammatory diseases: using molecular modelling and in-silico analysis of regulatory elements
The multi-protein targeting potential of bioactive syringin in inflammatory diseases: using molecular modelling and in-silico analysis of regulatory elements Open
Inflammation plays a crucial role in the onset or progression of a variety of acute and chronic diseases. Non-steroidal anti-inflammatory drugs (NSAIDs) are the only available FDA-approved therapy. The therapeutic outcome of NSAIDs is stil…
View article: Cellular landscaping of exosomal miRNAs in cancer metastasis: From chemoresistance to prognostic markers
Cellular landscaping of exosomal miRNAs in cancer metastasis: From chemoresistance to prognostic markers Open
Exosomes are cargos facilitating the transport of miRNAs across cancer cells. Exosomal miRNA has been an area of interest in recent times due to their triple role in cancer proliferation. The current review discusses the triple role of exo…
View article: Serum deprivation enhanced ethanol-induced toxic responses in A549, lung carcinoma cells
Serum deprivation enhanced ethanol-induced toxic responses in A549, lung carcinoma cells Open
Aim: The current study explores the toxic consequences of ethanol on human lung carcinoma cell, A549 in serum-deprived condition. Methodology: Human lung carcinoma cells, A549, were cultured in complete and serum-deprived medium for 6 hr. …