Vipul Gujrati
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View article: Bayesian reconstruction of rapidly scanned mid-infrared optoacoustic signals enables fast, label-free chemical microscopy
Bayesian reconstruction of rapidly scanned mid-infrared optoacoustic signals enables fast, label-free chemical microscopy Open
Hyperspectral optoacoustic microscopy (OAM) enables obtaining images with label-free biomolecular contrast, offering excellent perspectives as a diagnostic tool to assess freshly excised and unprocessed biological samples. However, time-co…
View article: Nonlinearity of optoacoustic signals and a new contrast mechanism for imaging
Nonlinearity of optoacoustic signals and a new contrast mechanism for imaging Open
View article: Photoswitching protein-XTEN fusions as injectable optoacoustic probes
Photoswitching protein-XTEN fusions as injectable optoacoustic probes Open
Optoacoustic imaging (OAI) is a unique in vivo imaging technique combining deep tissue penetration with high resolution and molecular sensitivity. OAI relying on strong intrinsic contrast, such as blood hemoglobin, already shows its value …
View article: Molecular rotors are loud, highly photostable, NIR/SWIR-active molecular optoacoustic contrast agents
Molecular rotors are loud, highly photostable, NIR/SWIR-active molecular optoacoustic contrast agents Open
Optoacoustic or photoacoustic imaging (PA) combines optical excitation with acoustic readout, for non-invasive in vivo imaging at up to several centimetres' penetration depth, and down to micron resolution. Conceptually, many chromophore t…
View article: Tuning the photophysical properties of cyanine by barbiturate functionalization and nanoformulation for efficient optoacoustics- guided phototherapy
Tuning the photophysical properties of cyanine by barbiturate functionalization and nanoformulation for efficient optoacoustics- guided phototherapy Open
Cyanine derivatives are organic dyes widely used for optical imaging. However, their potential in longitudinal optoacoustic imaging and photothermal therapy remains limited due to challenges such as poor chemical stability, poor photostabi…
View article: Merged Molecular Switches Excel as Optoacoustic Dyes: Azobenzene–Cyanines Are Loud and Photostable NIR Imaging Agents
Merged Molecular Switches Excel as Optoacoustic Dyes: Azobenzene–Cyanines Are Loud and Photostable NIR Imaging Agents Open
Optoacoustic (or photoacoustic) imaging promises micron‐resolution noninvasive bioimaging with much deeper penetration (>cm) than fluorescence. However, optoacoustic imaging of enzyme activity would require loud, photostable, NIR‐absorbing…
View article: Multimodal techniques and strategies for chemical and metabolic imaging at the single-cell level
Multimodal techniques and strategies for chemical and metabolic imaging at the single-cell level Open
Single-cell chemical and metabolic imaging technologies provide unprecedented insights into individual cell dynamics, advancing our understanding of cellular processes, molecular interactions, and metabolic activities. Advances in fluoresc…
View article: Merged molecular switches excel as optoacoustic dyes: azobenzene-cyanines are loud and photostable NIR imaging agents
Merged molecular switches excel as optoacoustic dyes: azobenzene-cyanines are loud and photostable NIR imaging agents Open
Optoacoustic imaging, also known as photoacoustic imaging, promises micron-resolution noninvasive imaging in biology at much deeper penetration (>cm) depths than e.g. fluorescence. However, the loud, photostable, NIR-absorbing molecular co…
View article: Bacterial outer membrane vesicles as cationic dye carriers for optoacoustics-guided phototherapy of cancer
Bacterial outer membrane vesicles as cationic dye carriers for optoacoustics-guided phototherapy of cancer Open
Background Cationic dyes are widely used as biomarkers for optical imaging. However, most of these are hydrophobic and cannot be employed in vivo without chemical conjugation or modification. Herein, we report for the first time the use of…
View article: Deep learning methods hold promise for light fluence compensation in three-dimensional optoacoustic imaging
Deep learning methods hold promise for light fluence compensation in three-dimensional optoacoustic imaging Open
The DL methods were able to compensate for nonlinear optical fluence distribution more effectively and improve the optoacoustic image quality.
View article: Multifunctional croconaine nanoparticles for efficient optoacoustic imaging of deep tumors and photothermal therapy
Multifunctional croconaine nanoparticles for efficient optoacoustic imaging of deep tumors and photothermal therapy Open
The proper design of near-infrared light-absorbing agents enables efficient optoacoustic imaging-guided phototherapy. In particular, several croconaine-based organic agents with excellent optical properties have been recently reported for …
View article: Reporter gene-based optoacoustic imaging of E. coli targeted colon cancer in vivo
Reporter gene-based optoacoustic imaging of E. coli targeted colon cancer in vivo Open
Bacteria-mediated cancer-targeted therapy is a novel experimental strategy for the treatment of cancers. Bacteria can be engineered to overcome a major challenge of existing therapeutics by differentiating between malignant and healthy tis…
View article: Reporter Gene-Based Optoacoustic Imaging of E. coli Targeted Colon Cancer In vivo
Reporter Gene-Based Optoacoustic Imaging of E. coli Targeted Colon Cancer In vivo Open
Bacteria-mediated cancer-targeted therapy is a novel experimental strategy for the treatment of cancers. Bacteria can be engineered to overcome a major challenge of existing therapeutics by differentiating between malignant and healthy tis…
View article: Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors
Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors Open
Contrast enhancement in optoacoustic (photoacoustic) imaging can be achieved with agents that exhibit high absorption cross-sections, high photostability, low quantum yield, low toxicity, and preferential bio-distribution and clearance pro…
View article: Facile Synthesis of a Croconaine‐Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy
Facile Synthesis of a Croconaine‐Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy Open
Near‐infrared (NIR) light absorbing theranostic agents can integrate optoacoustic imaging and photothermal therapy for effective personalized precision medicine. However, most of these agents face the challenges of unstable optical propert…
View article: Multiplexed whole-animal imaging with reversibly switchable optoacoustic proteins
Multiplexed whole-animal imaging with reversibly switchable optoacoustic proteins Open
Temporally unmixed optoacoustic enables routine in vivo imaging of transgene-labeled cells deep in the mouse body.
View article: Spatial heterogeneity of oxygenation and haemodynamics in breast cancer resolved in vivo by conical multispectral optoacoustic mesoscopy
Spatial heterogeneity of oxygenation and haemodynamics in breast cancer resolved in vivo by conical multispectral optoacoustic mesoscopy Open
View article: Short-wavelength optoacoustic spectroscopy based on water muting
Short-wavelength optoacoustic spectroscopy based on water muting Open
Infrared (IR) optoacoustic spectroscopy can separate a multitude of molecules based on their absorption spectra. However, the technique is limited when measuring target molecules in aqueous solution by strong water absorption at IR wavelen…
View article: Multiplexed whole animal imaging with reversibly switchable optoacoustic proteins
Multiplexed whole animal imaging with reversibly switchable optoacoustic proteins Open
We describe two photochromic proteins for cell-specific in vivo optoacoustic (OA) imaging with signal unmixing in the temporal domain. We show highly sensitive, multiplexed visualization of T lymphocytes, bacteria and tumors in the mouse b…
View article: Concurrent fluorescence and volumetric optoacoustic tomography of nanoagent perfusion and bio-distribution in solid tumors
Concurrent fluorescence and volumetric optoacoustic tomography of nanoagent perfusion and bio-distribution in solid tumors Open
Intravenously administered liposomes and other nano-sized particles are known to passively accumulate in solid tumors via the enhanced permeability and retention (EPR) effect, which is extensively explored toward the improvement of diagnos…
View article: Bioengineered bacterial vesicles as biological nano-heaters for optoacoustic imaging
Bioengineered bacterial vesicles as biological nano-heaters for optoacoustic imaging Open
View article: Molecular imaging probes for multi-spectral optoacoustic tomography
Molecular imaging probes for multi-spectral optoacoustic tomography Open
In this review, we discuss recent progress in emerging optoacoustic probes, their mechanisms, applications and challenges for biological imaging using MSOT.
View article: Photo-decomposable Organic Nanoparticles for Combined Tumor Optical Imaging and Multiple Phototherapies
Photo-decomposable Organic Nanoparticles for Combined Tumor Optical Imaging and Multiple Phototherapies Open
Combination of photodynamic therapy (PDT) with photothermal therapy (PTT) has achieved significantly improved therapeutic efficacy compared to a single phototherapy modality. However, most nanomaterials used for combined PDT/PTT are made o…
View article: Bioengineered yeast-derived vacuoles with enhanced tissue-penetrating ability for targeted cancer therapy
Bioengineered yeast-derived vacuoles with enhanced tissue-penetrating ability for targeted cancer therapy Open
Significance Tumor tissues have formidable physiological barriers, such as a high interstitial pressure and a densely entangled ECM. Most synthetic nanomaterials used for drug delivery fail to penetrate tumor tissues deeply and localize on…
View article: Mono-arginine Cholesterol-based Small Lipid Nanoparticles as a Systemic siRNA Delivery Platform for Effective Cancer Therapy
Mono-arginine Cholesterol-based Small Lipid Nanoparticles as a Systemic siRNA Delivery Platform for Effective Cancer Therapy Open
Although efforts have been made to develop a platform carrier for the delivery of RNAi therapeutics, systemic delivery of siRNA has shown only limited success in cancer therapy. Cationic lipid-based nanoparticles have been widely used for …