Virginia B Shipes
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View article: Designing a phase‐III time‐to‐event clinical trial using a modified sample size formula and Poisson‐Gamma model for subject accrual that accounts for the lag in site initiation using the <scp>PERT</scp> distribution
Designing a phase‐III time‐to‐event clinical trial using a modified sample size formula and Poisson‐Gamma model for subject accrual that accounts for the lag in site initiation using the <span>PERT</span> distribution Open
A priori estimation of sample size and subject accrual in multi‐site, time‐to‐event clinical trials is often challenging. Such trials are powered based on the number of events needed to detect a clinically significant difference. Sample si…
View article: J-shape relation of blood pressure reduction and outcome in acute intracerebral hemorrhage: A pooled analysis of INTERACT2 and ATACH-II individual participant data
J-shape relation of blood pressure reduction and outcome in acute intracerebral hemorrhage: A pooled analysis of INTERACT2 and ATACH-II individual participant data Open
Objective: The aim of this study was to better define the shape of association between the degree (“magnitude”) of early (< 1 h) reduction in systolic blood pressure (SBP) and outcomes in patients with acute intracerebral hemorrhage (ICH) …
View article: Intraoperative Methylprednisolone and Neurodevelopmental Outcomes in Infants After Cardiac Surgery
Intraoperative Methylprednisolone and Neurodevelopmental Outcomes in Infants After Cardiac Surgery Open
View article: Blood pressure control and clinical outcomes in acute intracerebral haemorrhage: a preplanned pooled analysis of individual participant data
Blood pressure control and clinical outcomes in acute intracerebral haemorrhage: a preplanned pooled analysis of individual participant data Open