Virginie Bertrand-Lehouillier
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View article: Rescuing DNMT1 fails to fully reverse the molecular and functional repercussions of its loss in mouse embryonic stem cells
Rescuing DNMT1 fails to fully reverse the molecular and functional repercussions of its loss in mouse embryonic stem cells Open
Epigenetic mechanisms are crucial for developmental programming and can be disrupted by environmental stressors, increasing susceptibility to disease. This has sparked interest in therapies for restoring epigenetic balance, but it remains …
View article: Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem Cells
Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem Cells Open
SUMMARY Epigenetic mechanisms are crucial for developmental programming and can be disrupted by environmental stressors, increasing susceptibility to disease. This has sparked interest in therapies for restoring epigenetic balance, but it …
View article: Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation
Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation Open
View article: Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin Through Downregulation of Histone Acetyltransferases
Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin Through Downregulation of Histone Acetyltransferases Open
Targeting MYC oncogene remains a major therapeutic goal in cancer chemotherapy. Here, we demonstrate that proscillaridin, a cardiac glycoside approved for heart failure treatment exhibit anticancer selectivity towards high MYC expressing l…
View article: Perturbation des profils épigénétiques suite à une perte temporaire du maintien de la méthylation de l’ADN dans les cellules embryonnaires
Perturbation des profils épigénétiques suite à une perte temporaire du maintien de la méthylation de l’ADN dans les cellules embryonnaires Open
Chez l’embryon précoce, une vague de reprogrammation majeure survient et permet de réinitialiser les profils de méthylation d’ADN de l’ensemble du génome. Lors de cette reprogrammation, les régions différentiellement méthylées (DMRs) (i.e.…
View article: Pre-implantation alcohol exposure and developmental programming of FASD: an epigenetic perspective
Pre-implantation alcohol exposure and developmental programming of FASD: an epigenetic perspective Open
Exposure to alcohol during in-utero development can permanently change the developmental programming of physiological responses, thereby increasing the risk of neurological illnesses during childhood and later adverse health outcomes assoc…