Virginie Gillet
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View article: Beyond discrete classifications: a computational approach to the continuum of cognition and behavior in children
Beyond discrete classifications: a computational approach to the continuum of cognition and behavior in children Open
Psychiatry is undergoing a shift toward precision medicine, demanding personalized approaches that capture the complexity of cognition and behavior. Here, we introduce a novel referential of four robust, replicable, and generalizable cogni…
View article: Beyond Discrete Classifications: A Computational Approach to the Continuum of Cognition and Behavior in Children
Beyond Discrete Classifications: A Computational Approach to the Continuum of Cognition and Behavior in Children Open
Psychiatry is undergoing a shift toward precision medicine, demanding personalized approaches that capture the complexity of cognition and behavior. Here, we introduce a novel referential of four robust, replicable, and generalizable cogni…
View article: Establishing non-fasting reference values for plasma lipids levels based on age, sex, and puberty stage in a French-Canadian pediatric population
Establishing non-fasting reference values for plasma lipids levels based on age, sex, and puberty stage in a French-Canadian pediatric population Open
Background Dyslipidemias, including familial hypercholesterolemia (FH), are a significant risk factor for cardiovascular diseases. FH is a genetic disorder resulting in elevated levels of low-density lipoprotein cholesterol (LDL-C) and an …
View article: In Utero Exposure to Caffeine and Acetaminophen, the Gut Microbiome, and Neurodevelopmental Outcomes: A Prospective Birth Cohort Study
In Utero Exposure to Caffeine and Acetaminophen, the Gut Microbiome, and Neurodevelopmental Outcomes: A Prospective Birth Cohort Study Open
Pregnant individuals are exposed to acetaminophen and caffeine, but it is unknown how these exposures interact with the developing gut microbiome. We aimed to determine whether acetaminophen and/or caffeine relate to the childhood gut micr…
View article: White matter microstructure associated with the range of attentional and impulsive performance in school-aged children
White matter microstructure associated with the range of attentional and impulsive performance in school-aged children Open
Introduction Inhibition capabilities have been shown to be a strong predictor of social and educational life outcomes (Mischel & Ebbesen, 1970; Shoda et al., 1990). Inhibition capabilities have an enormous impact on attention and impulsivi…
View article: White matter microstructural variability linked to differential attentional skills and impulsive behavior in a pediatric population
White matter microstructural variability linked to differential attentional skills and impulsive behavior in a pediatric population Open
Structural and functional magnetic resonance imaging (MRI) studies have suggested a neuroanatomical basis that may underly attention-deficit–hyperactivity disorder (ADHD), but the anatomical ground truth remains unknown. In addition, the r…
View article: Association of Prenatal Acetaminophen Exposure Measured in Meconium With Adverse Birth Outcomes in a Canadian Birth Cohort
Association of Prenatal Acetaminophen Exposure Measured in Meconium With Adverse Birth Outcomes in a Canadian Birth Cohort Open
Background The small number of studies examining the association of prenatal acetaminophen with birth outcomes have all relied on maternal self-report. It remains unknown whether prenatal acetaminophen exposure measured in a biological spe…
View article: Characterization of Children Exposure to Environmental Contaminants Using Stool in a Semi-Urban Middle-Class Cohort from Eastern Canada
Characterization of Children Exposure to Environmental Contaminants Using Stool in a Semi-Urban Middle-Class Cohort from Eastern Canada Open
View article: The relationship between persistent organic pollutants and Attention Deficit Hyperactivity Disorder phenotypes: Evidence from task-based neural activity in an observational study of a community sample of Canadian mother-child dyads
The relationship between persistent organic pollutants and Attention Deficit Hyperactivity Disorder phenotypes: Evidence from task-based neural activity in an observational study of a community sample of Canadian mother-child dyads Open
View article: In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels
In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels Open
Animal studies have shown that developmental exposures to polybrominated diphenyl ethers (PBDE) permanently affect blood/liver balance of lipids. No human study has evaluated associations between in utero exposures to persistent organic po…
View article: In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels
In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels Open
Animal studies have shown that developmental exposures to polybrominated diphenyl ethers (PBDE) permanently affect blood/liver balance of lipids. No human study has evaluated associations between in utero exposures to persistent organic po…
View article: Association of childhood and perinatal blood metals with children gut microbiome in a Canadian gestation cohort
Association of childhood and perinatal blood metals with children gut microbiome in a Canadian gestation cohort Open
BACKGROUND AND AIM: The gut microbiome is important in modulating health in childhood. Metal exposures affect multiple health outcomes, but their ability to modify bacterial communities in children is poorly understood. We assessed the ass…
View article: Prenatal Acetaminophen, Adverse Birth Outcomes, and ADHD: Mediation Analysis in a Prospective Cohort
Prenatal Acetaminophen, Adverse Birth Outcomes, and ADHD: Mediation Analysis in a Prospective Cohort Open
Structured Abstract Background Although we previously reported an association of prenatal acetaminophen exposure with more than two-fold increased odds of child ADHD, it is unknown whether prenatal acetaminophen is associated with adverse …
View article: The association between prenatal concentrations of polybrominated diphenyl ether and child cognitive and psychomotor function
The association between prenatal concentrations of polybrominated diphenyl ether and child cognitive and psychomotor function Open
Background: Previous studies suggest a negative association between prenatal polybrominated diphenyl ethers (PBDEs) exposure and child cognitive and psychomotor development. However, the timing of the relationship between PBDE exposure and…
View article: Methylparaben in Meconium and Risk of Maternal Thyroid Dysfunction, Adverse Birth Outcomes, and Attention-Deficit Hyperactivity Disorder
Methylparaben in Meconium and Risk of Maternal Thyroid Dysfunction, Adverse Birth Outcomes, and Attention-Deficit Hyperactivity Disorder Open
Background Parabens are detected ubiquitously in human urine samples, but the effects of prenatal exposure are unclear, partially due to inadequate exposure assessment in maternal urine, which may fail to capture fetal exposure. We examine…
View article: Association of Prenatal Acetaminophen Measured in Meconium with Attention-Deficit Hyperactivity Disorder
Association of Prenatal Acetaminophen Measured in Meconium with Attention-Deficit Hyperactivity Disorder Open
Background Multiple studies have shown an association between prenatal acetaminophen exposure and attention-deficit hyperactivity disorder (ADHD), but questions remain due to a paucity of quantifiable dose-response estimates and poor under…
View article: Association of Prenatal Acetaminophen Exposure Measured in Meconium With Risk of Attention-Deficit/Hyperactivity Disorder Mediated by Frontoparietal Network Brain Connectivity
Association of Prenatal Acetaminophen Exposure Measured in Meconium With Risk of Attention-Deficit/Hyperactivity Disorder Mediated by Frontoparietal Network Brain Connectivity Open
Together with the multitude of other cohort studies showing adverse neurodevelopment associated with prenatal acetaminophen exposure, this work suggests caution should be used in administering acetaminophen during pregnancy. Research into …
View article: Blood manganese and cognitive and motor skills at age 6-7 in Canadian cohort GESTE
Blood manganese and cognitive and motor skills at age 6-7 in Canadian cohort GESTE Open
Background: Increasing evidence suggests that high exposure to manganese (Mn) may impair brain development. In Canada, Mn exposure comes from several environmental sources and the most common is drinking water. Our objective was to examine…
View article: Methylparaben in meconium and risk of maternal thyroid dysfunction, adverse birth outcomes, and Attention-Deficit Hyperactivity Disorder (ADHD)
Methylparaben in meconium and risk of maternal thyroid dysfunction, adverse birth outcomes, and Attention-Deficit Hyperactivity Disorder (ADHD) Open
View article: Utilisation des exosomes circulants pour la détection précoce des changements épigénétiques du placenta et du cerveau fœtal reflétés par le profil miARN
Utilisation des exosomes circulants pour la détection précoce des changements épigénétiques du placenta et du cerveau fœtal reflétés par le profil miARN Open
Les complications de grossesse, telles que le diabète gestationnel (DG), la prééclampsie, et le retard de croissance intra-utérin sont intimement liées à un dysfonctionnement placentaire ayant des conséquences immédiates et à long-terme po…
View article: miRNA Profiles in Extracellular Vesicles From Serum Early in Pregnancies Complicated by Gestational Diabetes Mellitus
miRNA Profiles in Extracellular Vesicles From Serum Early in Pregnancies Complicated by Gestational Diabetes Mellitus Open
Context Underlying mechanisms leading to gestational diabetes mellitus (GDM) are still under investigation, and it is unclear whether the placenta plays a role in triggering glucose intolerance or if its functions are modified in response …
View article: Associations of prenatal exposure to polybrominated diphenyl ethers and polychlorinated biphenyls with long-term gut microbiome structure: a pilot study
Associations of prenatal exposure to polybrominated diphenyl ethers and polychlorinated biphenyls with long-term gut microbiome structure: a pilot study Open
Background: The gut microbiome is influenced by early-life exposures, but—despite potentially enormous implications for child health—is understudied in environmental epidemiology. This pilot study is one of the first to explore in utero ex…
View article: Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort
Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort Open
View article: 444: Fecal transplants disturb length of pregnancy in a mouse model
444: Fecal transplants disturb length of pregnancy in a mouse model Open