Virginie Joris
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View article: The use of molecular cues to regenerate musculoskeletal tissues
The use of molecular cues to regenerate musculoskeletal tissues Open
Introduction Musculoskeletal tissues, including bone, tendon, cartilage, and muscle, are vital for movement and structural support, yet, their repair after injury remains a significant clinical challenge. Their regeneration relies on compl…
View article: FGF9 treatment reduces off-target chondrocytes from iPSC-derived kidney organoids
FGF9 treatment reduces off-target chondrocytes from iPSC-derived kidney organoids Open
Renal failure due to drug nephrotoxicity or disease is frequently observed in patients. The development of in vitro models able to recapitulate kidney biology offers new possibilities to study drug toxicity or model diseases. Induced pluri…
View article: RNA extraction from cells, spheroids, or organoids encapsulated in alginate norbornene using Maxwell® RSC Plant RNA Kit v1
RNA extraction from cells, spheroids, or organoids encapsulated in alginate norbornene using Maxwell® RSC Plant RNA Kit v1 Open
This protocol details the isolation of RNA from cells, spheroids, or organoids encapsulated in alginate norbornene hydrogels using the Maxwell® RSC Plant RNA Kit and automated Maxwell® RSC instrument. The cells, spheroids, or organoids are…
View article: Early total care and damage control orthopaedics result in partially contrasting patterns of microRNA expression at the fracture site and in the systemic circulation
Early total care and damage control orthopaedics result in partially contrasting patterns of microRNA expression at the fracture site and in the systemic circulation Open
Aims The aims of this study, using a porcine model of multiple trauma, were to investigate the expression of microRNAs at the fracture site, in the fracture haematoma (fxH) and in the fractured bone, compared with a remote unfractured long…
View article: miR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells
miR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells Open
View article: MiR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells
MiR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells Open
Bone metabolism is highly regulated, and microRNAs (miR) can contribute to this process. Among them, miR-125b is well-known to enhance osteoporosis and reduce osteogenic differentiation of human mesenchymal stem cells (hMSCs). In this work…
View article: FGF9 treatment reduces off-target chondrocytes from iPSC-derived kidney organoids
FGF9 treatment reduces off-target chondrocytes from iPSC-derived kidney organoids Open
Summary Renal failure due to drug nephrotoxicity or disease is frequently observed in patients. The development of in vitro models able to recapitulate kidney biology offers new possibilities to study drug toxicity or model diseases. Induc…
View article: Identification of Compounds Protecting Pancreatic Islets against Oxidative Stress using a 3D Pseudoislet Screening Platform
Identification of Compounds Protecting Pancreatic Islets against Oxidative Stress using a 3D Pseudoislet Screening Platform Open
Oxidative stress leads to a lower success rate of clinical islet transplantation. Here, FDA‐approved compounds are screened for their potential to decrease oxidative stress and to protect or enhance pancreatic islet viability and function.…
View article: MiRNAs as Potential Regulators of Enthesis Healing: Findings in a Rodent Injury Model
MiRNAs as Potential Regulators of Enthesis Healing: Findings in a Rodent Injury Model Open
MicroRNAs (miRNAs) are short non-coding RNA sequences with the ability to inhibit the expression of a target mRNA at the post-transcriptional level, acting as modulators of both the degenerative and regenerative processes. Therefore, these…
View article: Ultrastructural comparison of human kidney organoids and human fetal kidneys reveals features of hyperglycemic culture
Ultrastructural comparison of human kidney organoids and human fetal kidneys reveals features of hyperglycemic culture Open
Induced pluripotent stem cell (iPSC)–derived kidney organoids have the potential for a large variety of applications. However, they do not persist long in culture, for which reasons are still unclear. Furthermore, their morphological matur…
View article: Enhanced Microvasculature Formation and Patterning in iPSC–Derived Kidney Organoids Cultured in Physiological Hypoxia
Enhanced Microvasculature Formation and Patterning in iPSC–Derived Kidney Organoids Cultured in Physiological Hypoxia Open
Stem cell–derived kidney organoids have been shown to self-organize from induced pluripotent stem cells into most important renal structures. However, the structures remain immature in culture and contain endothelial networks with low conn…
View article: AMPK Modulates the Metabolic Adaptation of C6 Glioma Cells in Glucose-Deprived Conditions without Affecting Glutamate Transport
AMPK Modulates the Metabolic Adaptation of C6 Glioma Cells in Glucose-Deprived Conditions without Affecting Glutamate Transport Open
Energy homeostasis in the central nervous system largely depends on astrocytes, which provide metabolic support and protection to neurons. Astrocytes also ensure the clearance of extracellular glutamate through high-affinity transporters, …
View article: miR-199a Downregulation as a Driver of the NOX4/HIF-1α/VEGF-A Pathway in Thyroid and Orbital Adipose Tissues from Graves′ Patients
miR-199a Downregulation as a Driver of the NOX4/HIF-1α/VEGF-A Pathway in Thyroid and Orbital Adipose Tissues from Graves′ Patients Open
Graves’ disease (GD) is an autoimmune thyroiditis often associated with Graves’ orbitopathy (GO). GD thyroid and GO orbital fat share high oxidative stress (OS) and hypervascularization. We investigated the metabolic pathways leading to OS…
View article: Enhanced microvasculature formation and patterning in iPSC–derived kidney organoids cultured in physiological hypoxia
Enhanced microvasculature formation and patterning in iPSC–derived kidney organoids cultured in physiological hypoxia Open
Functional kidney organoids have the potential to be used in implantable kidney grafts for patients with end-stage kidney disease, because they have been shown to self-organize from induced pluripotent stem cells into most important renal …
View article: Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1α, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto’s Thyroiditis
Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1α, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto’s Thyroiditis Open
In Hashimoto’s thyroiditis (HT), oxidative stress (OS) is driven by Th1 cytokines’ response interfering with the normal function of thyrocytes. OS results from an imbalance between an excessive production of reactive oxygen species (ROS) a…
View article: Downregulation of Caveolin-1 and Upregulation of Deiodinase 3, Associated with Hypoxia-Inducible Factor-1α Increase, Are Involved in the Oxidative Stress of Graves' Orbital Adipocytes
Downregulation of Caveolin-1 and Upregulation of Deiodinase 3, Associated with Hypoxia-Inducible Factor-1α Increase, Are Involved in the Oxidative Stress of Graves' Orbital Adipocytes Open
BACKGROUND: Even though the clinical features of Graves' orbitopathy (GO) are well known, its exact pathogenesis remains controversial. The imbalance of redox homeostasis in the connective tissue could play a crucial role leading to an inf…
View article: Brief O2 uploading during continuous hypothermic machine perfusion is simple yet effective oxygenation method to improve initial kidney function in a porcine autotransplant model
Brief O2 uploading during continuous hypothermic machine perfusion is simple yet effective oxygenation method to improve initial kidney function in a porcine autotransplant model Open
View article: MicroRNA-199a-3p and MicroRNA-199a-5p Take Part to a Redundant Network of Regulation of the NOS (NO Synthase)/NO Pathway in the Endothelium
MicroRNA-199a-3p and MicroRNA-199a-5p Take Part to a Redundant Network of Regulation of the NOS (NO Synthase)/NO Pathway in the Endothelium Open
Objective— Members of the microRNA (miR)-199a family, namely miR-199a-5p and miR-199a-3p, have been recently identified as potential regulators of cardiac homeostasis. Also, upregulation of miR-199a expression in cardiomyocytes was reporte…
View article: Perfusion-decellularization of human ear grafts enables ECM-based scaffolds for auricular vascularized composite tissue engineering
Perfusion-decellularization of human ear grafts enables ECM-based scaffolds for auricular vascularized composite tissue engineering Open
View article: Bioengineering a Human Face Graft
Bioengineering a Human Face Graft Open
Complex acellular facial scaffolds were obtained, preserving simultaneously a cell-friendly extracellular matrix and a perfusable vascular tree. This step will enable further engineering of postmortem facial grafts, thereby offering new pe…
View article: Partial cauda equina syndrome after an uneventful minimally invasive microdiscectomy in a patient with Crohn's disease
Partial cauda equina syndrome after an uneventful minimally invasive microdiscectomy in a patient with Crohn's disease Open
View article: Transcriptional and Epigenetic Controls of Vascular Homeostasis458Implication of microRNA 199a3p and 199a5p in vascular function : modulation of the eNOS/NO pathway459Role of endothelial cell adenosine deaminase acting on RNA-2 in ischemic/inflammatory disease in vivo460Adventitial activation by sonic hedgehog signaling is critical for vascular remodeling
Transcriptional and Epigenetic Controls of Vascular Homeostasis458Implication of microRNA 199a3p and 199a5p in vascular function : modulation of the eNOS/NO pathway459Role of endothelial cell adenosine deaminase acting on RNA-2 in ischemic/inflammatory disease in vivo460Adventitial activation by sonic hedgehog signaling is critical for vascular remodeling Open
Introduction: MiR 199a3p and 199a5p have been mainly implicated in proliferation, cell survival and remodeling in context of cancerogenesis but more recent data proposed a role in cardiovascular functions. Objectives: We seek…
View article: Involvement of mTOR and Regulation by AMPK in Early Iodine Deficiency-Induced Thyroid Microvascular Activation
Involvement of mTOR and Regulation by AMPK in Early Iodine Deficiency-Induced Thyroid Microvascular Activation Open
Iodine deficiency (ID) induces TSH-independent microvascular activation in the thyroid via the reactive oxygen species/nitric oxide-hypoxia-inducible factor-1α/vascular endothelial growth factor (VEGF) pathway. We hypothesized the addition…