Explanipedia

EXTH-91. Leveraging the cGAS-STING pathway to modulate the tumor microenvironment and enhance immunotherapies in glioblastoma Open

Louise Leparc, Judit Sánchez Gil, Catherine Sadzot‐Delvaux, Bernard Rogister, Samuel D. Rabkin , et al. · 2025

BACKGROUND Glioblastoma (GBM) is the most lethal primary brain tumor, characterized by rapid progression, treatment resistance, and an immunosuppressive tumor microenvironment (TME). The cGAS-STING pathway is a key sensor of cytosolic DNA …

BIOM-26. EPIGENETIC PROFILING OF PATIENT-DERIVED GLIOBLASTOMA CELLS USING NU.Q® IMMUNOASSAYS REVEALS A DISTINCT HISTONE MODIFICATION SIGNATURE Open

Jonathan Decarpentrie, Priscilla Van den Ackerveken, Clotilde Hannart, Nathalie Hardat, Ninon Ghys , et al. · 2025

Glioblastoma (GBM) is associated with profound epigenetic alterations contributing to tumor progression and therapy resistance. Identifying specific histone post-translational modifications (PTMs) in GBM may lead to novel biomarkers for di…

MODULATING AUTOPHAGY USING ONCOLYTIC HERPES SIMPLEX VIRUSES AND METFORMIN FOR IMMUNOTHERAPY IN GLIOBLASTOMA Open

Louise Leparc, Judit Sánchez Gil, Samuel D. Rabkin, Bernard Rogister, Catherine Sadzot , et al. · 2025

AIMS Glioblastoma (GBM) is the most aggressive primary brain tumor, necessitating innovative therapeutic ap- proaches. Although oncolytic herpes simplex viruses (oHSV) are promising therapies, their eﬃcacy as monotherapies is limited. In t…

ELUCIDATE ACKR3 EXPRESSION AND FUNCTION IN GLIOBLASTOMA-ASSOCIATED MICROENVIRONMENT Open

Miss Amandine Kuppens, Rob Leurs, Martyna Szpakowska, Andy Chevigné, Bernard Rogister , et al. · 2025

AIMS Glioblastoma is the most prevalent primary brain tumor in adults, leading to a grim prognosis. The development of eﬃcient therapies is limited by several factors, including the immunosuppressive tumor microenvironment. The chemokine r…

DEVELOPMENT AND VALIDATION OF A NEW PTK7-TARGETED AAV-MEDIATED SUICIDE-GENE THERAPY FOR GLIOBLASTOMA Open

Kim Mottard, Benoit Clette, Louise Leparc, Marylène Vandevenne, Alain Brans , et al. · 2025

AIMS Glioblastoma (GBM, IDH WT, grade 4) is a dreadful primary brain tumor. Despite the current standard-of-care, patient survival remains dramatically poor. This highlighting the urgent need for new therapeutic strategies. In this context…

INVESTIGATING THE CELLULAR AND MOLECULAR EFFECTS OF THE SUBVENTRICULAR ZONE ON HOSTED GLIOBLASTOMA CELLS Open

M.C. Lemoine, Joshua Scalisi, Bernard Rogister, Virginie Neirinckx · 2025

AIMS The subventricular zone (SVZ) is a unique zone of the brain located along the wall of the lateral ventricles. Glioblastomas (GBM) in contact with the SVZ are associated with a poorer prognosis. In mouse models, GBM cells migrate towar…

An oncolytic herpesvirus expressing a CXCR4 antagonist interferes with Glioblastoma cells stemness features and migration Open

Paolo D’Arrigo, Maxime Dubois, Judit Sánchez Gil, Cédric Lassence, Benoît Brouwers , et al. · 2025

Glioblastoma is one of the most aggressive brain tumors. Despite the standard therapy, the survival from diagnosis remains dramatically low, especially due to relapses. Considering their capacity to escape the tumor and to migrate to the s…

An integrated perspective on single-cell and spatial transcriptomic signatures in high-grade gliomas Open

C. Lemoine, Marcelo Leite da Veiga, Bernard Rogister, Caroline Piette, Virginie Neirinckx · 2025

Synaptic Vesicle Glycoprotein 2A Knockout in Parvalbumin and Somatostatin Interneurons Drives Seizures in the Postnatal Mouse Brain Open

Odile Bartholomé, Virginie Neirinckx, Orianne De La Brassinne, Jana Desloovere, Priscilla Van den Ackerveken , et al. · 2025

Synaptic vesicle glycoprotein 2A (SV2A) is a presynaptic protein targeted by the antiseizure drug levetiracetam. One or more of the three SV2 genes is expressed in all neurons and is essential to normal neurotransmission. Loss of SV2A resu…

Therapeutic targeting of the protein tyrosine kinase-7 in cancer: an overview Open

Kim Mottard, Julie Cokaiko, Bernard Rogister, Virginie Neirinckx · 2024

The protein tyrosine kinase-7 (PTK7) is an evolutionarily conserved transmembrane receptor that has emerged as a potential therapeutic target for human tumors. PTK7 is a pseudokinase that is involved in the modulation of the Wnt signaling …

Patient-based multilevel transcriptome exploration highlights relevant chemokines and chemokine receptor axes in glioblastoma Open

Giulia D’Uonnolo, Damla Isci, Bakhtiyor Nosirov, Amandine Kuppens, May Wantz , et al. · 2024

Heterogeneous expression of the atypical chemokine receptor ACKR3 in glioblastoma patient-derived tissue samples and cell cultures Open

Damla Isci, Amandine Kuppens, Joshua Scalisi, Julie Cokaiko, Giulia D’Uonnolo , et al. · 2024

Development of an intraventricular Adeno-Associated Virus-based labelling strategy for glioblastoma cells nested in the subventricular zone Open

Arnaud Lombard, Damla Isci, Gilles Reuter, Emmanuel Di Valentin, Alexandre Hego , et al. · 2024

Background Glioblastoma (GBM) is a dreadful brain tumor, with a particular relationship to the adult subventricular zone (SVZ) that has been described as relevant to disease initiation, progression, and recurrence. Methods We propose a nov…

Preclinical evaluation of CXCR4 peptides for targeted radionuclide therapy in glioblastoma Open

Anthony Waked, Melissa Crabbé, Virginie Neirinckx, Sunay Rodriguez Pérez, Jasmien Wellens , et al. · 2024

Heterogeneous expression of the atypical chemokine receptor ACKR3 in glioblastoma patient-derived tissue samples and cell cultures. Open

Damla Isci, Amandine Kuppens, Joshua Scalisi, Julie Cokaiko, Giulia D’Uonnolo , et al. · 2024

Background: Glioblastoma (GBM) is the most aggressive glial tumor of the adult brain, associated with invariably fatal outcome, and a deeper understanding of the underlying malignant mechanisms is necessary to address the current therapeut…

190P Immune-related roles of B7H3 in glioblastoma Open

Ana Simonet, Damla Isci, Virginie Neirinckx, Guy Jérusalem, Bernard Rogister · 2023

DNAR-13. TARGETING THE DNA DAMAGE RESPONSE IN GLIOBLASTOMA PROPAGATING CELLS: FROM MOLECULAR MECHANISMS TO PRECISION MEDICINE Open

Alexandros Pailas, Katrin Neumann, Céline Jeanty, Christel Herold‐Mende, Réka Tóth , et al. · 2023

Glioblastoma (GBM) is the most aggressive and lethal primary tumor of the central nervous system (CNS). Despite surgical resection and a combination of radiotherapy and alkylation chemotherapy, the median survival for patients with newly d…

Comprehensive profiling of stem-like features in pediatric glioma cell cultures and their relation to the subventricular zone Open

Marc-Antoine Da-Veiga, Natacha Coppieters, Arnaud Lombard, Bernard Rogister, Virginie Neirinckx , et al. · 2023

Nanobody-based retargeting of an oncolytic herpesvirus for eliminating CXCR4+ GBM cells: A proof of principle Open

Judit Sánchez Gil, Maxime Dubois, Virginie Neirinckx, Arnaud Lombard, Natacha Coppieters , et al. · 2022

Glioma Stem Cells in Pediatric High-Grade Gliomas: From Current Knowledge to Future Perspectives Open

Marc-Antoine Da-Veiga, Bernard Rogister, Arnaud Lombard, Virginie Neirinckx, Caroline Piette · 2022

In children, high-grade gliomas (HGG) and diffuse midline gliomas (DMG) account for a high proportion of death due to cancer. Glioma stem cells (GSCs) are tumor cells in a specific state defined by a tumor-initiating capacity following ser…

Patient-Oriented Perspective on Chemokine Receptor Expression and Function in Glioma Open

Damla Isci, Giulia D’Uonnolo, May Wantz, Bernard Rogister, Arnaud Lombard , et al. · 2021

Gliomas are severe brain malignancies, with glioblastoma (GBM) being the most aggressive one. Despite continuous efforts for improvement of existing therapies, overall survival remains poor. Over the last years, the implication of chemokin…

Correction: Human bone marrow harbors cells with neural crest-associated characteristics like human adipose and dermis tissues Open

Cécile Coste, Virginie Neirinckx, Anil Sharma, Gulistan Agirman, Bernard Rogister , et al. · 2021

[This corrects the article DOI: 10.1371/journal.pone.0177962.].

Correction: In Vivo Tumorigenesis Was Observed after Injection of In Vitro Expanded Neural Crest Stem Cells Isolated from Adult Bone Marrow Open

Sabine Wislet‐Gendebien, Christophe Poulet, Virginie Neirinckx, Benoît Hennuy, James T. Swingland , et al. · 2021

[This corrects the article DOI: 10.1371/journal.pone.0046425.].

Correction to: Adult bone marrow mesenchymal and neural crest stem cells are chemoattractive and accelerate motor recovery in a mouse model of spinal cord injury Open

Virginie Neirinckx, Gulistan Agirman, Cécile Coste, Alice Marquet, Valérie Dion , et al. · 2021

Retraction Note: Mesenchymal stem cells and neural crest stem cells from adult bone marrow: characterization of their surprising similarities and differences Open

Sabine Wislet‐Gendebien, Emerence Laudet, Virginie Neirinckx, Philippe Alix, Pierre Leprince , et al. · 2021

Editor’s Note: Adult bone marrow mesenchymal and neural crest stem cells are chemoattractive and accelerate motor recovery in a mouse model of spinal cord injury Open

Virginie Neirinckx, Gulistan Agirman, Cécile Coste, Alice Marquet, Valérie Dion , et al. · 2021

AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion Open

Anne Schuster, Eliane Klein, Virginie Neirinckx, Arnon Møldrup Knudsen, Carina Fabian , et al. · 2020

The infiltrative nature of Glioblastoma (GBM), the most aggressive primary brain tumor, critically prevents complete surgical resection and masks tumor cells behind the blood brain barrier reducing the efficacy of systemic treatment. Here,…

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology Open

Anna Golebiewska, Ann‐Christin Hau, Anaïs Oudin, Daniel Stieber, Yahaya A Yabo , et al. · 2020

A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons Open

Odile Bartholomé, Orianne de la Brassinne Bonardeaux, Virginie Neirinckx, Bernard Rogister · 2020

Parvalbumin-positive neurons are inhibitory neurons that release GABA and are mostly represented by fast-spiking basket or chandelier cells. They constitute a minor neuronal population, yet their peculiar profiles allow them to react quick…

CSIG-04. PAN-RTK INHIBITION OF sLRIG1 MEDIATES AXL DOWNREGULATION IN GLIOBLASTOMA Open

Virginie Neirinckx, Ann‐Christin Hau, Anne Schuster, Sabrina Fritah, Andy Chevigné , et al. · 2019

INTRODUCTION Aberrant regulation of receptor tyrosine kinase (RTK) activity is characteristic of Glioblastoma (GBM). However, RTK-based targeted therapies have been largely unsuccessful in GBM patients, partially due to the complexity and …

Virginie Neirinckx YOU? Author Swipe