Virve Kärkkäinen
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View article: Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease
Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease Open
View article: The annual incidence of vascular dementia and other dementias: A population-based study in Eastern Finland
The annual incidence of vascular dementia and other dementias: A population-based study in Eastern Finland Open
Introduction: Considering the globally growing population and the rising incidence of dementia, it is important to understand the proportion of dementia cases affected by vascular brain disease. We aimed to study the incidence of vascular …
View article: Gut Microbiome Changes in Patients With Idiopathic Normal Pressure Hydrocephalus
Gut Microbiome Changes in Patients With Idiopathic Normal Pressure Hydrocephalus Open
Background: The gut microbiome is a complex system within the human gastrointestinal tract. The bacteria play a significant role in human health, and some can promote inflammation and pathologic processes through chemical interactions or m…
View article: Acute evacuation of 54 intracerebral hematomas (aICH) during the microsurgical clipping of a ruptured middle cerebral artery bifurcation aneurysm—illustration of the individual clinical courses and outcomes with a serial brain CT/MRI panel until 12 months
Acute evacuation of 54 intracerebral hematomas (aICH) during the microsurgical clipping of a ruptured middle cerebral artery bifurcation aneurysm—illustration of the individual clinical courses and outcomes with a serial brain CT/MRI panel until 12 months Open
View article: Prevalence of pre‐eclampsia in 265 patients with an intracranial aneurysm, 393 female relatives versus a control cohort: A case–control study
Prevalence of pre‐eclampsia in 265 patients with an intracranial aneurysm, 393 female relatives versus a control cohort: A case–control study Open
Background and objectives There is emerging evidence on the connection between pre‐eclampsia and saccular intracranial aneurysms (sIAs). Our aim was to study the prevalence of pre‐eclampsia in sIA patients, their female relatives, and matc…
View article: Should individual timeline and serial CT/MRI panels of all patients be presented in acute brain insult cohorts? A pilot study of 45 patients with decompressive craniectomy after aneurysmal subarachnoid hemorrhage
Should individual timeline and serial CT/MRI panels of all patients be presented in acute brain insult cohorts? A pilot study of 45 patients with decompressive craniectomy after aneurysmal subarachnoid hemorrhage Open
View article: Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired
Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired Open
Background: Functional defects in eye movements and reduced reading speed in neurodegenerative diseases represent a potential new biomarker to support clinical diagnosis. We investigated whether computer-based eye-tracking (ET) analysis of…
View article: Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer’s Disease
Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer’s Disease Open
Background: Wide-ranging functional defects in eye movements have been reported in Alzheimer’s disease (AD) dementia. The detection of abnormal eye movements and reading problems may identify persons at risk of AD when clear clinical sympt…
View article: Pet ownership supports quality of life in home‐dwelling people with Alzheimer's disease
Pet ownership supports quality of life in home‐dwelling people with Alzheimer's disease Open
Objectives Human‐animal interactions have beneficial psychosocial and psychophysiological effects on individuals in both the presence and absence of medical health conditions. No previous prospective studies with long follow‐up have invest…
View article: Shunt performance in 349 patients with hydrocephalus after aneurysmal subarachnoid hemorrhage
Shunt performance in 349 patients with hydrocephalus after aneurysmal subarachnoid hemorrhage Open
View article: Lentivirus vector‑mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain
Lentivirus vector‑mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain Open
Translation of promising experimental therapies from rodent models to clinical success has been complicated as the novel therapies often fail in clinical trials. Existing rodent glioma models generally do not allow for preclinical evaluati…
View article: Clinical condition of 120 patients alive at 3 years after poor-grade aneurysmal subarachnoid hemorrhage
Clinical condition of 120 patients alive at 3 years after poor-grade aneurysmal subarachnoid hemorrhage Open
View article: Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder
Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder Open
Neural stem/progenitor cells (NPCs) generate new neurons in the brain throughout the lifetime in an intricate process called neurogenesis. Neurogenic alterations are a common feature of several adult-onset neurodegenerative diseases. The n…
View article: Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis Open
Unfortunately, after publication of this article [1], an error was discovered in Fig. 12 (Fig. 1 here) that was introduced during the Production process. The corrected figure can be seen below and the original article has also been updated…
View article: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis Open