Vishaal Rajani
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View article: Src dependency of the regulation of LTP by alternative splicing of <i>GRIN1</i> exon 5
Src dependency of the regulation of LTP by alternative splicing of <i>GRIN1</i> exon 5 Open
Alternative splicing of Grin1 exon 5 regulates induction of long-term potentiation (LTP) at Schaffer collateral-CA1 synapses: LTP in mice lacking the GluN1 exon 5-encoded N1 cassette (GluN1a mice) is significantly increased compared with t…
View article: A Review on Exploring the Phytochemical and Pharmacological Significance of <i>Indigofera astragalina</i>
A Review on Exploring the Phytochemical and Pharmacological Significance of <i>Indigofera astragalina</i> Open
Indigofera astragalina, a versatile medicinal plant, has gained significant attention because of its rich phytochemical composition and diverse therapeutic properties. I. astragalina contains sterols, phenolics, alkaloids, and flavonoids, …
View article: Hippocampal hyperphosphorylated tau-induced deficiency is rescued by L-type calcium channel blockade
Hippocampal hyperphosphorylated tau-induced deficiency is rescued by L-type calcium channel blockade Open
Aging and Alzheimer’s disease are associated with chronic elevations in neuronal calcium influx via L-type calcium channels. The hippocampus, a primary memory encoding structure in the brain, is more vulnerable to calcium dysregulation in …
View article: Olfactory threat extinction in the piriform cortex: An age-dependent employment of NMDA receptor-dependent long-term depression
Olfactory threat extinction in the piriform cortex: An age-dependent employment of NMDA receptor-dependent long-term depression Open
Extinction of threat memory is a measure of behavioral flexibility. In the absence of additional reinforcement, the extinction of learned behaviors allows animals and humans to adapt to their changing environment. Extinction mechanisms and…
View article: Contributions of carotid bodies, retrotrapezoid nucleus neurons and preBötzinger complex astrocytes to the CO<sub>2</sub>‐sensitive drive for breathing
Contributions of carotid bodies, retrotrapezoid nucleus neurons and preBötzinger complex astrocytes to the CO<sub>2</sub>‐sensitive drive for breathing Open
Current models of respiratory CO 2 chemosensitivity are centred around the function of a specific population of neurons residing in the medullary retrotrapezoid nucleus (RTN). However, there is significant evidence suggesting that chemosen…
View article: Modulation of L-type calcium channels in Alzheimer’s disease: A potential therapeutic target
Modulation of L-type calcium channels in Alzheimer’s disease: A potential therapeutic target Open
View article: Noradrenergic Modulation of the Piriform Cortex: A Possible Avenue for Understanding Pre-Clinical Alzheimer’s Disease Pathogenesis
Noradrenergic Modulation of the Piriform Cortex: A Possible Avenue for Understanding Pre-Clinical Alzheimer’s Disease Pathogenesis Open
Olfactory dysfunction is one of the biomarkers for Alzheimer’s disease (AD) diagnosis and progression. Deficits with odor identification and discrimination are common symptoms of pre-clinical AD, preceding severe memory disorder observed i…
View article: Aging differentially affects LTCC function in hippocampal CA1 and piriform cortex pyramidal neurons
Aging differentially affects LTCC function in hippocampal CA1 and piriform cortex pyramidal neurons Open
Aging is associated with cognitive decline and memory loss in humans. In rats, aging-associated neuronal excitability changes and impairments in learning have been extensively studied in the hippocampus. Here, we investigated the roles of …
View article: Age-Dependent Contributions of NMDA Receptors and L-Type Calcium Channels to Long-Term Depression in the Piriform Cortex
Age-Dependent Contributions of NMDA Receptors and L-Type Calcium Channels to Long-Term Depression in the Piriform Cortex Open
In the hippocampus, the contributions of N-methyl-D-aspartate receptors (NMDARs) and L-type calcium channels (LTCCs) to neuronal transmission and synaptic plasticity change with aging, underlying calcium dysregulation and cognitive dysfunc…
View article: Alternative splicing of GluN1 gates glycine site–dependent nonionotropic signaling by NMDAR receptors
Alternative splicing of GluN1 gates glycine site–dependent nonionotropic signaling by NMDAR receptors Open
Significance N -methyl-D-aspartate receptors (NMDARs), which are critical in the brain, are increasingly being shown to signal without ion flux (i.e., “metabotropically”). What controls the metabotropic function of NMDARs is unknown. We di…
View article: Alternative splicing of GluN1 gates glycine-primed internalization of NMDA receptors
Alternative splicing of GluN1 gates glycine-primed internalization of NMDA receptors Open
Summary N-methyl-D-aspartate receptors (NMDARs), a principal subtype of excitatory neurotransmitter receptor, are composed as tetrameric assemblies of two glycine-binding GluN1 subunits and two glutamate-binding GluN2 subunits. Gating of t…
View article: Tripartite signalling by NMDA receptors
Tripartite signalling by NMDA receptors Open
N -methyl- d -aspartate receptors (NMDARs) are excitatory glutamatergic receptors that are fundamental for many neuronal processes, including synaptic plasticity. NMDARs are comprised of four subunits derived from heterogeneous subunit fam…
View article: Release of ATP by pre‐Bötzinger complex astrocytes contributes to the hypoxic ventilatory response via a Ca<sup>2+</sup>‐dependent P2Y<sub>1</sub> receptor mechanism
Release of ATP by pre‐Bötzinger complex astrocytes contributes to the hypoxic ventilatory response via a Ca<sup>2+</sup>‐dependent P2Y<sub>1</sub> receptor mechanism Open
Key points The ventilatory response to reduced oxygen (hypoxia) is biphasic, comprising an initial increase in ventilation followed by a secondary depression. Our findings indicate that, during hypoxia, astrocytes in the pre‐Bötzinger comp…
View article: Excitatory Modulation of the preBötzinger Complex Inspiratory Rhythm Generating Network by Endogenous Hydrogen Sulfide
Excitatory Modulation of the preBötzinger Complex Inspiratory Rhythm Generating Network by Endogenous Hydrogen Sulfide Open
Hydrogen Sulfide (H2S) is one of three gasotransmitters that modulate excitability in the CNS. Global application of H2S donors or inhibitors of H2S synthesis to the respiratory network has suggested that i…
View article: Purinergic and Glial Signalling in the Hypoxic Ventilatory Response
Purinergic and Glial Signalling in the Hypoxic Ventilatory Response Open
The hypoxic ventilatory response comprises of an initial increase in ventilation, followed by a secondary depression that can be life threatening in premature infants. During hypoxia, ATP is released in the ventrolateral medulla, where it …