Vinod K. Srivastava
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View article: Association of cholinergic biomarkers with postoperative delirium in elderly patients undergoing regional anesthesia - An observational study
Association of cholinergic biomarkers with postoperative delirium in elderly patients undergoing regional anesthesia - An observational study Open
Background and Aims: Postoperative delirium (POD) is a prevalent and serious complication in elderly patients undergoing surgery, contributing to prolonged hospital stays and increased morbidity. While the exact mechanism remains elusive, …
View article: Ultrasound-Guided Suprainguinal Versus Infrainguinal Fascia Iliaca Compartment Block for Postoperative Analgesia After Total Knee Replacement: A Prospective Randomized Trial
Ultrasound-Guided Suprainguinal Versus Infrainguinal Fascia Iliaca Compartment Block for Postoperative Analgesia After Total Knee Replacement: A Prospective Randomized Trial Open
[This corrects the article DOI: 10.7759/cureus.84453.].
View article: Orphan nuclear receptor transcription factors as drug targets
Orphan nuclear receptor transcription factors as drug targets Open
The nuclear receptor (NR) superfamily of ligand-activated receptors plays a key role in maintaining cellular homeostasis and in pathophysiology. NRs can be subdivided into functional activities structural similarity and the existence of en…
View article: Ultrasound-Guided Suprainguinal Versus Infrainguinal Fascia Iliaca Compartment Block for Postoperative Analgesia After Total Knee Replacement: A Prospective Randomized Trial
Ultrasound-Guided Suprainguinal Versus Infrainguinal Fascia Iliaca Compartment Block for Postoperative Analgesia After Total Knee Replacement: A Prospective Randomized Trial Open
View article: Cell-Based Small-Molecule Screening Identifying Proteostasis Regulators Enhancing Factor VIII Missense Mutant Secretion
Cell-Based Small-Molecule Screening Identifying Proteostasis Regulators Enhancing Factor VIII Missense Mutant Secretion Open
Missense mutations are the most prevalent alterations in genetic disorders such as hemophilia A (HA), which results from coagulation factor VIII (FVIII) deficiencies. These mutations disrupt protein biosynthesis, folding, secretion, and fu…
View article: Manganese-induced Precocious Puberty Alters Mammary Epithelial Cell Proliferation in Female Rats
Manganese-induced Precocious Puberty Alters Mammary Epithelial Cell Proliferation in Female Rats Open
Precocious puberty (PP) is an established breast cancer risk factor. In the normal mammary gland, hormone receptor-positive (HR+) cells rarely proliferate. In breast cancer, proliferating epithelial cells are often HR+. It is not known if …
View article: Perfluorooctane Sulfonate (PFOS) and Related Compounds Induce Nuclear Receptor 4A1 (NR4A1)-Dependent Carcinogenesis
Perfluorooctane Sulfonate (PFOS) and Related Compounds Induce Nuclear Receptor 4A1 (NR4A1)-Dependent Carcinogenesis Open
Polyfluoroalkyl substances (PFAS) are widely used industrial compounds that have been identified as contaminants in almost every component of the global ecosystem, and in human studies, higher levels of PFAS have been correlated with incre…
View article: Comparison of Lignocaine-Dexamethasone vs. Lignocaine-Triamcinolone for Preventing Post Spinal-Epidural Backache: A Randomized Study
Comparison of Lignocaine-Dexamethasone vs. Lignocaine-Triamcinolone for Preventing Post Spinal-Epidural Backache: A Randomized Study Open
View article: Effect of Dopamine as a Vascular Endothelial Growth Factor Antagonist on the Development of Acute Lung Injury in Sepsis Patients
Effect of Dopamine as a Vascular Endothelial Growth Factor Antagonist on the Development of Acute Lung Injury in Sepsis Patients Open
View article: Determinants of Readmission in the Intensive Care Unit: A Prospective Observational Study
Determinants of Readmission in the Intensive Care Unit: A Prospective Observational Study Open
View article: Strain-specific requirements of susceptibility to rhesus enteric calicivirus infection
Strain-specific requirements of susceptibility to rhesus enteric calicivirus infection Open
Recently, we identified the coxsackie and adenovirus receptor (CAR) as the entry receptor for rhesus enteric calicivirus (ReCV) isolate FT285 and demonstrated that co-expression of the CAR and the type B histo-blood group antigen (HBGA) is…
View article: Involuntary Lung Nodules Recognition in Computed Tomography Images using 3D features Mining and Neural System
Involuntary Lung Nodules Recognition in Computed Tomography Images using 3D features Mining and Neural System Open
The best precise imaging method for determining the presence and stage of lung cancer is considered to be computed tomography (CT). On a chest X-ray, nodules are a legitimately frequent abnormality: one out of every 500 chest X-rays reveal…
View article: Perioperative Anxiolysis and Analgesic Effect after Premedication with Melatonin and Pregabalin in Total Hip Arthroplasty under Spinal Anaesthesia: A Prospective Comparative Trial
Perioperative Anxiolysis and Analgesic Effect after Premedication with Melatonin and Pregabalin in Total Hip Arthroplasty under Spinal Anaesthesia: A Prospective Comparative Trial Open
Background: Preoperative anxiety plays a critical role in post-operative pain response and other outcomes. Melatonin is a naturally secreted hormone which has anxiolytic, sedative, and analgesic properties. Pregabalin, analogue of gabapent…
View article: Effect of Deferasirox on Shunt Fraction During Thoracic Surgery With One-Lung Ventilation: A Randomized Controlled Study
Effect of Deferasirox on Shunt Fraction During Thoracic Surgery With One-Lung Ventilation: A Randomized Controlled Study Open
View article: Effect of breathing intervention in patients with COVID and healthcare workers
Effect of breathing intervention in patients with COVID and healthcare workers Open
Background Regulated breathing facilitates ventilation and reduces breathlessness. However, the effect of Yogic breathing on patients with COVID remains unclear. We aimed to evaluate the efficacy of two breathing protocols, i.e., short bre…
View article: A Randomized, Double-Blind, Prospective Study to Evaluate the Effect of Oral Pregabalin in Upper Limb Surgeries Under Brachial Plexus Block
A Randomized, Double-Blind, Prospective Study to Evaluate the Effect of Oral Pregabalin in Upper Limb Surgeries Under Brachial Plexus Block Open
View article: A randomized controlled trial comparing Macintosh laryngoscope and Airtraq video laryngoscope for endotracheal intubation in patients with thyroid swelling
A randomized controlled trial comparing Macintosh laryngoscope and Airtraq video laryngoscope for endotracheal intubation in patients with thyroid swelling Open
Background: Patients with thyroid swelling are anticipated difficult airway due to the anatomical complications associated with it leading to restricted neck movements and distorted laryngeal anatomy. The aim of this randomized prospective…
View article: Efficacy of Oral Care Protocols in the Prevention of Ventilator-Associated Pneumonia in Mechanically Ventilated Patients
Efficacy of Oral Care Protocols in the Prevention of Ventilator-Associated Pneumonia in Mechanically Ventilated Patients Open
Oral care with chlorhexidine mouth wash and the adjuvant measures reduced VAP and, consequently mortality and hospital stays. Tooth brushing along with standard oral care provides an additional advantage in the prevention of VAP in mechani…
View article: Genotyping of Clinical Parameters in Age-Related Macular Degeneration
Genotyping of Clinical Parameters in Age-Related Macular Degeneration Open
Priya Battu,1,* Kaushal Sharma,1,* Rajarathna Thangavel,2 Ramandeep Singh,3 Suresh Sharma,4 Vinod Srivastava,5 Akshay Anand1 1Neuroscience Research Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research, Ch…
View article: How alcohol affects insulin‐like growth factor‐1's influences on the onset of puberty: A critical review
How alcohol affects insulin‐like growth factor‐1's influences on the onset of puberty: A critical review Open
Alcohol (ALC) is capable of delaying signs associated with pubertal development in laboratory animals, as well as in humans. The normal onset of puberty results from a timely increase in gonadotropin‐releasing hormone (GnRH) secretion, whi…
View article: A Comparative Study of the ProSeal Laryngeal Mask Airway Versus Endotracheal Tube in Neonates With Anorectal Malformations
A Comparative Study of the ProSeal Laryngeal Mask Airway Versus Endotracheal Tube in Neonates With Anorectal Malformations Open
The ProSeal LMA can be a better alternative to the endotracheal tube in neonates due to the ease of insertion, lesser changes in hemodynamic parameters and minimal postoperative complications.
View article: Yoga Practice Is Beneficial for Maintaining Healthy Lifestyle and Endurance Under Restrictions and Stress Imposed by Lockdown During COVID-19 Pandemic
Yoga Practice Is Beneficial for Maintaining Healthy Lifestyle and Endurance Under Restrictions and Stress Imposed by Lockdown During COVID-19 Pandemic Open
Uncertainty about Coronavirus disease 2019 (COVID-19) and resulting lockdown caused widespread panic, stress, and anxiety. Yoga is a known practice that reduces stress and anxiety and may enhance immunity. This study aimed to (1) investiga…
View article: A retrospective study on the seasonal occurrence of Japanese Encephalitis cases in Uttar Pradesh
A retrospective study on the seasonal occurrence of Japanese Encephalitis cases in Uttar Pradesh Open
Background: Japanese encephalitis (JE) is a dreaded mosquito-borne viral disease, especially in Asian, Western Pacific, and Northern Australia region and a major public health problem in India. In India, State of Uttar Pradesh contributed …
View article: IGF-1 Influences Gonadotropin-Releasing Hormone Regulation of Puberty
IGF-1 Influences Gonadotropin-Releasing Hormone Regulation of Puberty Open
The pubertal process is initiated as a result of complex neuroendocrine interactions within the preoptic and hypothalamic regions of the brain. These interactions ultimately result in a timely increase in the secretion of gonadotropin-rele…
View article: Evidence-Based Public Health Annual Conference of Epidemiology Foundation of India, All India Institute of Medical Sciences, Rishikesh
Evidence-Based Public Health Annual Conference of Epidemiology Foundation of India, All India Institute of Medical Sciences, Rishikesh Open
View article: Effectiveness of a quality improvement intervention to increase adherence to key practices during female sterilization services in Chhattisgarh and Odisha states of India
Effectiveness of a quality improvement intervention to increase adherence to key practices during female sterilization services in Chhattisgarh and Odisha states of India Open
Background In response to longstanding concerns around the quality of female sterilization services provided at public health facilities in India, the Government of India issued standards and quality assurance guidelines for female sterili…
View article: Prevalence of Diabetes and Its Determinants in the Young Adults Indian Population-Call for Yoga Intervention
Prevalence of Diabetes and Its Determinants in the Young Adults Indian Population-Call for Yoga Intervention Open
Background The young Indian population, which constitutes 65% of the country, is fast adapting to a new lifestyle, which was not known earlier. They are at a high risk of the increasing burden of diabetes and associated complications. The …
View article: INVESTIGATING WHETHER ECOLOGICAL MODELS OF COMMUNITY-ORIENTED VARIABLES IMPROVE PREDICTION OF CHILDHOOD RESILIENCE OVER A SET OF PERSONAL CHARACTERISTIC VARIABLES SUCH AS IMPULSE CONTROL, EMOTIONAL REGULATION, RELATIONAL MOTIVATION, AND SELF-RELIANCE
INVESTIGATING WHETHER ECOLOGICAL MODELS OF COMMUNITY-ORIENTED VARIABLES IMPROVE PREDICTION OF CHILDHOOD RESILIENCE OVER A SET OF PERSONAL CHARACTERISTIC VARIABLES SUCH AS IMPULSE CONTROL, EMOTIONAL REGULATION, RELATIONAL MOTIVATION, AND SELF-RELIANCE Open
Children experiencing trauma and entering child protective services have been continuously increasing. Problems associated with childhood trauma, such as neurodevelopmental disorder, trauma and stress-related disorders, personality disorde…
View article: Erratum: Prevalence and Awareness of Stroke and Other Comorbidities Associated with Diabetes in Northwest India
Erratum: Prevalence and Awareness of Stroke and Other Comorbidities Associated with Diabetes in Northwest India Open
[This corrects the article DOI: 10.1055/s-0040-1709369.].