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View article: Circulating Testican-2 and MGT5A are Markers of Membranous Nephropathy
Circulating Testican-2 and MGT5A are Markers of Membranous Nephropathy Open
View article: Exome-Wide Analysis Identifies a Rare EXD3 Missense Variant Associated With Diabetic Kidney Disease
Exome-Wide Analysis Identifies a Rare EXD3 Missense Variant Associated With Diabetic Kidney Disease Open
View article: #3074 An external validation of polygenic risk scores in the general population using measured GFR—the renal iohexol clearance survey (RENIS)
#3074 An external validation of polygenic risk scores in the general population using measured GFR—the renal iohexol clearance survey (RENIS) Open
Background and Aims Extensive genome-wide association studies (GWAS) have found a large number of single nucleotide variants (SNVs) linked to estimated glomerular filtration rate (eGFR). eGFR derived from creatinine or cystatin-C is used a…
View article: Polygenic Risk Scores Predicting Estimated GFR Validated With Iohexol Clearance
Polygenic Risk Scores Predicting Estimated GFR Validated With Iohexol Clearance Open
View article: Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney
Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney Open
Building upon a foundational Human Kidney resource, we present a comprehensive multi-modal atlas that defines spatially resolved versus unresolved repair states and mechanisms in human kidney disease. Homeostatic interactions between injur…
View article: A Human Glomerular Disease Atlas defines the APOL1-JAK-STAT feed forward loop in focal segmental glomerulosclerosis
A Human Glomerular Disease Atlas defines the APOL1-JAK-STAT feed forward loop in focal segmental glomerulosclerosis Open
To map transcriptional programs in rare glomerular diseases, single-nucleus RNA sequencing (snRNAseq) on kidney biopsies (N=120) from the Nephrotic Syndrome Study Network were integrated with snRNAseq and single-cell sequencing (scRNAseq) …
View article: A renal biopsy–anchored multi-marker signature involving AOPEP SNP-driven splicing, miR-27b-3p and glycated albumin for stratifying renal damage in type 2 diabetes
A renal biopsy–anchored multi-marker signature involving AOPEP SNP-driven splicing, miR-27b-3p and glycated albumin for stratifying renal damage in type 2 diabetes Open
We identify a genotype- and glucose-dependent mechanism regulating miR-27b-3p via AOPEP splicing and propose a biopsy-anchored, non-invasive biomarker panel (rs10761364, GA, miR-27b-3p) to differentiate DN from NDRD, supporting personalize…
View article: Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage
Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage Open
DNA repair is essential for preserving genome integrity. Podocytes, postmitotic epithelial cells of the kidney filtration unit, bear limited regenerative capacity, yet their survival is indispensable for kidney health. Podocyte loss is a h…
View article: The growth hormone/IGF-1 axis is a risk factor for long-term kidney allograft failure
The growth hormone/IGF-1 axis is a risk factor for long-term kidney allograft failure Open
INTRODUCTIONMaladaptive hypertrophy, podocyte stress, and depletion contribute to kidney function decline. Although insulin-like growth factor 1 (IGF-1) plays a key role in early hypertrophic responses in the single kidney state, its impac…
View article: Empowering Education: A Cloud Based E-Learning Platform
Empowering Education: A Cloud Based E-Learning Platform Open
Our website revolutionizes student time management through advanced analytics, optimizing study habits for academic and career success. By amalgamating time management tools, personalized counseling, and e-learning, we empower students to …
View article: Leveraging complementary multi-omics data integration methods for mechanistic insights in kidney diseases
Leveraging complementary multi-omics data integration methods for mechanistic insights in kidney diseases Open
Chronic kidney diseases (CKDs) are a global health concern, necessitating a comprehensive understanding of their complex pathophysiology. This study explores the use of 2 complementary multidimensional -omics data integration methods to el…
View article: Framework for precision medicine in focal segmental glomerulosclerosis: Translation of sparsentan-responsive genes in a rat model to kidney disease associated proteins in biofluids
Framework for precision medicine in focal segmental glomerulosclerosis: Translation of sparsentan-responsive genes in a rat model to kidney disease associated proteins in biofluids Open
Sparsentan, a dual endothelin receptor A inhibitor and angiotensin blocker, reduced proteinuria in patients with focal segmental glomerulosclerosis (FSGS) in Phase II and Phase III studies. However, the estimated glomerular filtration rate…
View article: HR's Role in Fostering Ethical Behavior and Corporate Social Responsibility (CSR)
HR's Role in Fostering Ethical Behavior and Corporate Social Responsibility (CSR) Open
As organizations face increasing pressure to prioritize ethical practices and social responsibility, Human Resources (HR) is uniquely positioned to drive these initiatives. This manuscript examines the critical role of HR in fostering ethi…
View article: WCN25-3719 URINARY TNFR2 IS ASSOCIATED WITH KIDNEY DAMAGE IN PATIENTS WITH NEPHROTIC SYNDROME
WCN25-3719 URINARY TNFR2 IS ASSOCIATED WITH KIDNEY DAMAGE IN PATIENTS WITH NEPHROTIC SYNDROME Open
View article: WCN25-3179 URINARY BIOMARKERS ASSOCIATED WITH DIGITAL PATHOLOGY DESCRIPTORS ASSOCIATE WITH OUTCOMES IN PATIENTS WITH NEPHROTIC SYNDROME
WCN25-3179 URINARY BIOMARKERS ASSOCIATED WITH DIGITAL PATHOLOGY DESCRIPTORS ASSOCIATE WITH OUTCOMES IN PATIENTS WITH NEPHROTIC SYNDROME Open
View article: WCN25-3713 MOLECULAR PROFILING FROM THE RENAL AL AMYLOID INVOLVEMENT AND NEOD00 (RAIN) TRIAL SHOW HETEROGENEITY IN GENE EXPRESSION
WCN25-3713 MOLECULAR PROFILING FROM THE RENAL AL AMYLOID INVOLVEMENT AND NEOD00 (RAIN) TRIAL SHOW HETEROGENEITY IN GENE EXPRESSION Open
View article: The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury
The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury Open
The role played by anionic channels in diabetic kidney disease (DKD) is not known. Chloride channel accessory 1 (CLCA1) facilitates the activity of TMEM16A (Anoctamin-1), a Ca2+-dependent Cl- channel. We examined if CLCA1/TMEM16A had a rol…
View article: INTERPERSONAL COMMUNICATION, EMOTIONAL INTELLIGENCE, CONFLICT RESOLUTION, RELATIONAL SATISFACTION AMONG INTIMATE PARTNERS
INTERPERSONAL COMMUNICATION, EMOTIONAL INTELLIGENCE, CONFLICT RESOLUTION, RELATIONAL SATISFACTION AMONG INTIMATE PARTNERS Open
Romantic relationships significantly impact individuals' mental health, emotional well-being, and life satisfaction. Effective communication, emotional intelligence, and conflict resolution are critical to maintaining relational harmony. H…
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View article: Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease
Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease Open
View article: Association of Urinary Epidermal Growth Factor, Fatty Acid-Binding Protein 3, and Vascular Cell Adhesion Molecule 1 Levels with the Progression of Early Diabetic Kidney Disease
Association of Urinary Epidermal Growth Factor, Fatty Acid-Binding Protein 3, and Vascular Cell Adhesion Molecule 1 Levels with the Progression of Early Diabetic Kidney Disease Open
Introduction: Diabetic kidney disease (DKD) is a common cause of chronic kidney disease with around 25–40% of patients with diabetes being affected. The course of DKD is variable, and estimated glomerular filtration rate (eGFR) and albumin…
View article: Analysis of Glomerular Transcriptomes from Nephrotic Patients Suggest<i>APOL1</i>Risk Variants Impact Parietal Epithelial Cells
Analysis of Glomerular Transcriptomes from Nephrotic Patients Suggest<i>APOL1</i>Risk Variants Impact Parietal Epithelial Cells Open
The disproportionate risk for idiopathic proteinuric podocytopathies in Black people is explained, in part, by the presence of two risk alleles (G1 or G2) in the APOL1 gene. The pathogenic mechanisms responsible for this genetic associatio…
View article: Attenuated kidney oxidative metabolism in young adults with type 1 diabetes
Attenuated kidney oxidative metabolism in young adults with type 1 diabetes Open
BACKGROUNDIn type 1 diabetes (T1D), impaired insulin sensitivity may contribute to the development of diabetic kidney disease (DKD) through alterations in kidney oxidative metabolism.METHODSYoung adults with T1D (n = 30) and healthy contro…
View article: A Novel Role for FERM Domain-Containing Protein 3 in CKD
A Novel Role for FERM Domain-Containing Protein 3 in CKD Open
Key Points We have identified a transcriptional signature of 93 genes associated with CKD severity and progression. Protein 4.1, ezrin, radixin, moesin domain-containing protein 3 gene expression is reduced in the context of more severe ki…
View article: A <i>MEF2C</i> transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease
A <i>MEF2C</i> transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease Open
The maintenance of a healthy epithelial-endothelial juxtaposition requires cross-talk within glomerular cellular niches. We sought to understand the spatially-anchored regulation and transition of endothelial and mesangial cells from healt…
View article: Scaling up, Sustaining, and Enhancing School-Based Sexuality Education Programs in Resource Constrained and Conservative Contexts: Replicable Lessons from Positive-Deviant Countries
Scaling up, Sustaining, and Enhancing School-Based Sexuality Education Programs in Resource Constrained and Conservative Contexts: Replicable Lessons from Positive-Deviant Countries Open
Despite considerable efforts, progress in the implementationof sexuality education (SE) has been uneven. This study identi-fied six “positive-deviant” low- and middle-income countries,i.e., countries that had scaled up, sustained and enhan…
View article: Gene Expression Sets and Renal Profiling from the Renal AL Amyloid Involvement and NEOD00 (RAIN) Trial
Gene Expression Sets and Renal Profiling from the Renal AL Amyloid Involvement and NEOD00 (RAIN) Trial Open
Despite the small sample size, we identified 2 distinct groups of patients with AL based on molecular signatures. Detailed studies of a larger cohort encompassing omics technologies at a single cell resolution will further help to identify…
View article: WCN24-1441 INTERFERON GAMMA (IFN-γ) IN EARLY DIABETIC KIDNEY DISEASE IS ASSOCIATED WITH PROGRESSION TO KIDNEY FAILURE
WCN24-1441 INTERFERON GAMMA (IFN-γ) IN EARLY DIABETIC KIDNEY DISEASE IS ASSOCIATED WITH PROGRESSION TO KIDNEY FAILURE Open
View article: WCN24-385 PREDICTING PATIENT RESPONSE TO STANDARD-OF-CARE THERAPIES IN GLOMERULAR DISEASES
WCN24-385 PREDICTING PATIENT RESPONSE TO STANDARD-OF-CARE THERAPIES IN GLOMERULAR DISEASES Open
Glucocorticoids and calcineurin inhibitors (CNI) are part of KDIGO guidelines for treatment of steroid resistant glomerular diseases. Despite widespread use, predicting whether a patient will respond to therapy remains elusive. Given toxic…
View article: Glomerular Elasticity and Gene Expression Patterns Define Two Phases of Alport Nephropathy
Glomerular Elasticity and Gene Expression Patterns Define Two Phases of Alport Nephropathy Open
To understand the early stages of Alport nephropathy, we characterize the structural, functional, and biophysical properties of glomerular capillaries and podocytes in Col4α3 -/- mice, analyze kidney cortex transcriptional profiles over ti…