Vishruth Girish
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View article: Changes in the Skin Microbiome Following Dermatological Procedures: A Scoping Review
Changes in the Skin Microbiome Following Dermatological Procedures: A Scoping Review Open
The skin microbiome consists of bacteria, fungi, viruses, and mites, which play a crucial role in maintaining skin health and immune function. Imbalances in this microbial community, known as dysbiosis, are implicated in various dermatolog…
View article: Oncogene-like addiction to aneuploidy in human cancers
Oncogene-like addiction to aneuploidy in human cancers Open
Most cancers exhibit aneuploidy, but its functional significance in tumor development is controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using CRISPR Targeting), a set of chromosome engineering tools that allow…
View article: Oncogene-like addiction to aneuploidy in human cancers
Oncogene-like addiction to aneuploidy in human cancers Open
Most cancers exhibit aneuploidy, but its functional significance in tumor development is controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using CRISPR Targeting), a set of chromosome engineering tools that allow…
View article: Combustible and Electronic Cigarette Exposures Increase ACE2 Activity and SARS-CoV-2 Spike Binding
Combustible and Electronic Cigarette Exposures Increase ACE2 Activity and SARS-CoV-2 Spike Binding Open
To the Editor: The outbreak of coronavirus disease (COVID-19) has extensively impacted global health. The spike protein on the surface of the causative pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the angi…
View article: Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies
Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies Open
View article: Combustible and electronic cigarette exposures increase ACE2 activity and SARS-CoV-2 Spike binding
Combustible and electronic cigarette exposures increase ACE2 activity and SARS-CoV-2 Spike binding Open
The outbreak of coronavirus disease 2019 (COVID-19) has extensively impacted global health. The causative pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), binds to the angiotensin-converting enzyme 2 (ACE2) receptor,…
View article: Correction Notice: A CRISPR Competition Assay to Identify Cancer Genetic Dependencies
Correction Notice: A CRISPR Competition Assay to Identify Cancer Genetic Dependencies Open
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View article: Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract
Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract Open
View article: Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract
Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract Open
The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show that cigarette smoke causes a dose-dependent upregulation of Angiotensin Converting Enzyme 2 (ACE2), the SARS-CoV-2 receptor, in rodent and human lungs.…
View article: A CRISPR Competition Assay to Identify Cancer Genetic Dependencies
A CRISPR Competition Assay to Identify Cancer Genetic Dependencies Open
The CRISPR/Cas9 system is a powerful tool for genome editing, wherein the RNA-guided nuclease Cas9 can be directed to introduce double-stranded breaks (DSBs) at a targeted locus. In mammalian cells, these DSBs are typically repaired throug…
View article: Generating Single Cell–Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9
Generating Single Cell–Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9 Open
CRISPR/Cas9 technology enables the rapid generation of loss‐of‐function mutations in a targeted gene in mammalian cells. A single cell harboring those mutations can be used to establish a new cell line, thereby creating a CRISPR‐induced kn…