Vidit Sharma
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View article: Spatial proteomics to discover aging-associated alterations in the renal tubulointerstitium
Spatial proteomics to discover aging-associated alterations in the renal tubulointerstitium Open
View article: Spatial Mass Spectrometry-Based Proteomic Analysis of Normal-Appearing Glomeruli from Young and Old Adults
Spatial Mass Spectrometry-Based Proteomic Analysis of Normal-Appearing Glomeruli from Young and Old Adults Open
Background: Kidney aging is characterized by a loss of glomeruli, predominately in the superficial cortex, with a resultant decline in glomerular filtration rate and an increased risk of various kidney-related diseases. The early molecular…
View article: Imatinib-Associated Hyperkeratotic Eruptions: A Rare Extensor Surface Manifestation
Imatinib-Associated Hyperkeratotic Eruptions: A Rare Extensor Surface Manifestation Open
View article: Cost-Effectiveness of Trimodal Therapy and Radical Cystectomy for Muscle-Invasive Bladder Cancer
Cost-Effectiveness of Trimodal Therapy and Radical Cystectomy for Muscle-Invasive Bladder Cancer Open
Importance Trimodal therapy (TMT) is included as an alternative to radical cystectomy (RC) for definitive management of muscle-invasive bladder cancer (MIBC) in current clinical guidelines. Moreover, a 2023 retrospective analysis reported …
View article: Lower Podocyte Number per Glomerulus Associates With Progressive CKD
Lower Podocyte Number per Glomerulus Associates With Progressive CKD Open
View article: Glomerular and Nephron Size and Kidney Disease Outcomes: A Comparison of Manual Versus Deep Learning Methods in Kidney Pathology
Glomerular and Nephron Size and Kidney Disease Outcomes: A Comparison of Manual Versus Deep Learning Methods in Kidney Pathology Open
View article: Stenosis of the glomerulotubular neck in progressive chronic kidney disease
Stenosis of the glomerulotubular neck in progressive chronic kidney disease Open
Background Morphology and morphometric evaluation of lesions beyond conventional parameters can inform the pathophysiology of chronic kidney disease (CKD). We sought to determine whether the occurrence of glomerulotubular neck stenoses ass…
View article: Artificial intelligence model for automated surgical instrument detection and counting: an experimental proof-of-concept study
Artificial intelligence model for automated surgical instrument detection and counting: an experimental proof-of-concept study Open
Background Retained surgical items (RSI) are preventable events that pose a significant risk to patient safety. Current strategies for preventing RSIs rely heavily on manual instrument counting methods, which are prone to human error. This…
View article: Lifetime Health and Economic Outcomes of Biparametric Magnetic Resonance Imaging as First-Line Screening for Prostate Cancer
Lifetime Health and Economic Outcomes of Biparametric Magnetic Resonance Imaging as First-Line Screening for Prostate Cancer Open
National Cancer Institute.
View article: Association of Kidney Cysts With Progressive CKD After Radical Nephrectomy
Association of Kidney Cysts With Progressive CKD After Radical Nephrectomy Open
View article: Navigating Now and Next: Recent Advances and Future Horizons in Robotic Radical Prostatectomy
Navigating Now and Next: Recent Advances and Future Horizons in Robotic Radical Prostatectomy Open
Robotic-assisted radical prostatectomy (RARP) has become the leading approach for radical prostatectomy driven by innovations aimed at improving functional and oncological outcomes. The initial advancement in this field was transperitoneal…
View article: Tubular and Glomerular Size by Cortex Depth as Predictor of Progressive CKD after Radical Nephrectomy for Tumor
Tubular and Glomerular Size by Cortex Depth as Predictor of Progressive CKD after Radical Nephrectomy for Tumor Open
Significance Statement Glomerular size differs by cortex depth. Larger nephrons are prognostic of progressive kidney disease, but it is unknown whether this risk differs by cortex depth or by glomeruli versus proximal or distal tubule size…
View article: A Novel PD-L1 Antibody Promotes Antitumor Function of Peripheral Cytotoxic Lymphocytes after Radical Nephrectomy in Patients with Renal Cell Carcinoma
A Novel PD-L1 Antibody Promotes Antitumor Function of Peripheral Cytotoxic Lymphocytes after Radical Nephrectomy in Patients with Renal Cell Carcinoma Open
The intrinsic and acquired resistance to PD-1/PD-L1 immune checkpoint blockade is an important challenge for patients and clinicians because no reliable tool has been developed to predict individualized response to immunotherapy. In this s…
View article: An Improved Method for Estimating Nephron Number and the Association of Resulting Nephron Number Estimates with Chronic Kidney Disease Outcomes
An Improved Method for Estimating Nephron Number and the Association of Resulting Nephron Number Estimates with Chronic Kidney Disease Outcomes Open
Significance Statement Nephron number currently can be estimated only from glomerular density on a kidney biopsy combined with cortical volume from kidney imaging. Because of measurement biases, refinement of this approach and validation a…
View article: Effect of Dataset Size and Medical Image Modality on Convolutional Neural Network Model Performance for Automated Segmentation: A CT and MR Renal Tumor Imaging Study
Effect of Dataset Size and Medical Image Modality on Convolutional Neural Network Model Performance for Automated Segmentation: A CT and MR Renal Tumor Imaging Study Open
The aim of this study is to investigate the use of an exponential-plateau model to determine the required training dataset size that yields the maximum medical image segmentation performance. CT and MR images of patients with renal tumors …
View article: Bladder Recurrence Following Upper Tract Surgery for Urothelial Carcinoma: A Contemporary Review of Risk Factors and Management Strategies
Bladder Recurrence Following Upper Tract Surgery for Urothelial Carcinoma: A Contemporary Review of Risk Factors and Management Strategies Open
View article: Natural History of Multiple Recurrences in Intermediate-Risk Non-Muscle Invasive Bladder Cancer: Lessons From a Prospective Cohort
Natural History of Multiple Recurrences in Intermediate-Risk Non-Muscle Invasive Bladder Cancer: Lessons From a Prospective Cohort Open
View article: Discovery of a novel monoclonal PD-L1 antibody H1A that promotes T-cell mediated tumor killing activity in renal cell carcinoma
Discovery of a novel monoclonal PD-L1 antibody H1A that promotes T-cell mediated tumor killing activity in renal cell carcinoma Open
In the last decade, the therapeutic landscape of renal cell carcinoma has rapidly evolved with the addition of PD-1/PD-L1 immune checkpoint inhibitors in the armamentarium of oncologists. Despite clinical evidence of improved oncological o…
View article: Magnetic Resonance Imaging-Guided Biopsy in Active Surveillance of Prostate Cancer
Magnetic Resonance Imaging-Guided Biopsy in Active Surveillance of Prostate Cancer Open
When AS begins and follows with MRGBx (targeted and systematic), upgrading rate (≥GG3) is greater when tumor is initially present within a magnetic resonance imaging lesion or when pathology is GG2 than when these features are absent.
View article: Treatment patterns, outcomes, and costs associated with localized upper tract urothelial carcinoma
Treatment patterns, outcomes, and costs associated with localized upper tract urothelial carcinoma Open
Background Upper tract urothelial carcinoma (UTUC) is a heterogeneous disease that presents a clinical management challenge for the urologic surgeon. We assessed treatment patterns, costs, and survival outcomes among patients with nonmetas…
View article: Treatment Patterns, Outcomes, and Costs Associated With Localized Upper Tract Urothelial Carcinoma
Treatment Patterns, Outcomes, and Costs Associated With Localized Upper Tract Urothelial Carcinoma Open
Background Upper tract urothelial carcinoma (UTUC) is a heterogeneous disease that presents a clinical management challenge for the urologic surgeon. We assessed treatment patterns, costs, and survival outcomes among patients with nonmetas…
View article: PD25-10 COST-UTILITY ANALYSIS IN UROLOGY
PD25-10 COST-UTILITY ANALYSIS IN UROLOGY Open
You have accessJournal of UrologyHealth Services Research: Value of Care: Cost and Outcomes Measures II (PD25)1 Sep 2021PD25-10 COST-UTILITY ANALYSIS IN UROLOGY Katherine Fero, Vidit Sharma, Patrick Lec, Christopher Saigal, and Karim Chami…
View article: PD25-03 THE INCIDENCE AND PREDICTORS OF FINANCIAL TOXICITY IN A PROSPECTIVE COHORT OF PATIENTS WITH NON-MUSCLE INVASIVE BLADDER CANCER
PD25-03 THE INCIDENCE AND PREDICTORS OF FINANCIAL TOXICITY IN A PROSPECTIVE COHORT OF PATIENTS WITH NON-MUSCLE INVASIVE BLADDER CANCER Open
You have accessJournal of UrologyHealth Services Research: Value of Care: Cost and Outcomes Measures II (PD25)1 Sep 2021PD25-03 THE INCIDENCE AND PREDICTORS OF FINANCIAL TOXICITY IN A PROSPECTIVE COHORT OF PATIENTS WITH NON-MUSCLE INVASIVE…
View article: PD25-09 IMPLICATIONS OF THE RADIATION ONCOLOGY ALTERNATIVE PAYMENT MODEL ON PROSTATE CANCER CARE: ESTIMATES FROM MEDICARE EPISODES
PD25-09 IMPLICATIONS OF THE RADIATION ONCOLOGY ALTERNATIVE PAYMENT MODEL ON PROSTATE CANCER CARE: ESTIMATES FROM MEDICARE EPISODES Open
You have accessJournal of UrologyHealth Services Research: Value of Care: Cost and Outcomes Measures II (PD25)1 Sep 2021PD25-09 IMPLICATIONS OF THE RADIATION ONCOLOGY ALTERNATIVE PAYMENT MODEL ON PROSTATE CANCER CARE: ESTIMATES FROM MEDICA…
View article: Incidence and predictors of occult preoperative deep vein thrombosis at radical cystectomy for urothelial carcinoma
Incidence and predictors of occult preoperative deep vein thrombosis at radical cystectomy for urothelial carcinoma Open
Introduction: Patients undergoing radical cystectomy are at high perioperative risk for deep vein thrombosis due to age, malignancy, recent transurethral resection, and neoadjuvant chemotherapy. We, therefore, evaluated the incidence and p…
View article: Relationship Between Mobile Digital Sensor Monitoring and Perioperative Outcomes: Systematic Review
Relationship Between Mobile Digital Sensor Monitoring and Perioperative Outcomes: Systematic Review Open
Background Monitoring surgical recovery has traditionally been confined to metrics measurable within the hospital and clinic setting. However, commercially available mobile sensors are now capable of extending measurements into a patient’s…
View article: Differential prognostic impact of different Gleason patterns in grade group 4 in radical prostatectomy specimens
Differential prognostic impact of different Gleason patterns in grade group 4 in radical prostatectomy specimens Open
View article: Development and Validation of a Clinical Prognostic Stage Group System for Nonmetastatic Prostate Cancer Using Disease-Specific Mortality Results From the International Staging Collaboration for Cancer of the Prostate
Development and Validation of a Clinical Prognostic Stage Group System for Nonmetastatic Prostate Cancer Using Disease-Specific Mortality Results From the International Staging Collaboration for Cancer of the Prostate Open
Using a large, diverse international cohort treated with standard curative treatment options, a proposed AJCC-compliant clinical prognostic stage group system for prostate cancer has been developed. This system may allow consistency of rep…
View article: Comparative cost-effectiveness of percutaneous nephrolithotomy, ureteroscopy, and extracorporeal shock wave lithotripsy for the management of 1-2 cm renal stones
Comparative cost-effectiveness of percutaneous nephrolithotomy, ureteroscopy, and extracorporeal shock wave lithotripsy for the management of 1-2 cm renal stones Open
View article: Salvage radical prostatectomy in the setting of non-metastatic castration-resistant recurrent prostate cancer: Outcomes from a retrospective multicenter series
Salvage radical prostatectomy in the setting of non-metastatic castration-resistant recurrent prostate cancer: Outcomes from a retrospective multicenter series Open