Viswanathan Natarajan
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View article: CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity
CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity Open
The expression of endothelial-enriched receptor tyrosine kinase Tie2 and vascular endothelial cadherin VE-cadherin in endothelial cells (EC) is essential for maintaining endothelial barrier integrity and vascular homeostasis. The Ets famil…
View article: Fingolimod, a sphingosine-1-phosphate receptor modulator, prevents neonatal bronchopulmonary dysplasia and subsequent airway remodeling in a murine model
Fingolimod, a sphingosine-1-phosphate receptor modulator, prevents neonatal bronchopulmonary dysplasia and subsequent airway remodeling in a murine model Open
The role of the S1P receptor1 modulator, fingolimod, as an FDA-approved drug in preventing the recurrence of multiple sclerosis is established. Fingolimod prevented bronchopulmonary dysplasia (BPD) and its sequela of airway remodeling in a…
View article: To identify risk factors for central visual field progression in moderate to advanced glaucoma
To identify risk factors for central visual field progression in moderate to advanced glaucoma Open
Purpose: To identify the risk factors for central visual field progression in moderate to advanced glaucoma. Methods: We included patients with moderate to advanced primary glaucoma who had undergone at least five reliable Humphrey visual …
View article: Botulinum toxin A as a treatment modality for acute acquired comitant esotropia – An Indian perspective
Botulinum toxin A as a treatment modality for acute acquired comitant esotropia – An Indian perspective Open
Purpose: To analyze the outcomes of botulinum toxin A injection in acute acquired comitant esotropia (AACE). Methods: This is a retrospective study that included cases diagnosed as AACE between January 2022 and February 2023. Patients who …
View article: Endothelial knockdown of the tumor suppressor, <i>WWOX</i> , increases inflammation in ventilator-induced lung injury
Endothelial knockdown of the tumor suppressor, <i>WWOX</i> , increases inflammation in ventilator-induced lung injury Open
Prior tobacco smoke exposure is associated with an increased risk of acute respiratory distress syndrome (ARDS) during critical illness. Our laboratory is investigating one of the gene expression changes that occurs in the lung following s…
View article: Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model
Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model Open
The role of SPHK1-specific inhibitor, PF543, in preventing goblet cell metaplasia (GCM) and airway hyperreactivity (AHR) is established in an allergen-induced mouse model. This protection was associated with the downregulation of NOTCH2-SP…
View article: trans-Endothelial neutrophil migration activates bactericidal function via Piezo1 mechanosensing
trans-Endothelial neutrophil migration activates bactericidal function via Piezo1 mechanosensing Open
The regulation of polymorphonuclear leukocyte (PMN) function by mechanical forces encountered during their migration across restrictive endothelial cell junctions is not well understood. Using genetic, imaging, microfluidic, and in vivo ap…
View article: Endothelial Knockdown of the Tumor Suppressor, WWOX, Increases Inflammation in Ventilator-Induced Lung Injury
Endothelial Knockdown of the Tumor Suppressor, WWOX, Increases Inflammation in Ventilator-Induced Lung Injury Open
Background Chronic cigarette smoke exposure downregulates lung expression of WWOX, an ARDS relevant tumor suppressor. Prior work has revealed a barrier protective function of WWOX during infectious models of ARDS. Proteomic analysis of WWO…
View article: Intraocular lens formula calculation in pediatric eyes: Do we have an answer? A retrospective comparison between Sanders–Retzlaff–Kraff II and Barret’s formula
Intraocular lens formula calculation in pediatric eyes: Do we have an answer? A retrospective comparison between Sanders–Retzlaff–Kraff II and Barret’s formula Open
Purpose: The ideal formula for intraocular lens (IOL) power calculation following cataract surgery in pediatric eyes till date has no answer. We compared the predictability of the Sanders–Retzlaff–Kraff (SRK) II and the Barrett Universal (…
View article: Sphingosine Kinase 1 Deficiency in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension via YAP1 Signaling
Sphingosine Kinase 1 Deficiency in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension via YAP1 Signaling Open
Sphingosine kinase 1 (SPHK1) and the sphingosine-1-phosphate (S1P) signaling pathway have been shown to play a role in pulmonary arterial hypertension (PAH). S1P is an important stimulus for pulmonary artery smooth muscle cell (PASMC) prol…
View article: eNAMPT Neutralization Preserves Lung Fluid Balance and Reduces Acute Renal Injury in Porcine Sepsis/VILI-Induced Inflammatory Lung Injury
eNAMPT Neutralization Preserves Lung Fluid Balance and Reduces Acute Renal Injury in Porcine Sepsis/VILI-Induced Inflammatory Lung Injury Open
Background: Numerous potential ARDS therapeutics, based upon preclinical successful rodent studies that utilized LPS challenge without mechanical ventilation, have failed in Phase 2/3 clinical trials. Recently, ALT-100 mAb, a novel biologi…
View article: NOX4 Mediates Epithelial Cell Death in Hyperoxic Acute Lung Injury Through Mitochondrial Reactive Oxygen Species
NOX4 Mediates Epithelial Cell Death in Hyperoxic Acute Lung Injury Through Mitochondrial Reactive Oxygen Species Open
Management of acute respiratory distress involves O 2 supplementation, which is lifesaving, but causes severe hyperoxic acute lung injury (HALI). NADPH oxidase (NOX) could be a major source of reactive oxygen species (ROS) in hyperoxia (HO…
View article: Cortactin loss protects against hemin-induced acute lung injury in sickle cell disease
Cortactin loss protects against hemin-induced acute lung injury in sickle cell disease Open
In patients with sickle cell disease (SCD), acute chest syndrome (ACS) is a common form of acute lung injury and a major cause of morbidity and mortality. The pathophysiology of ACS is complex, and hemin, the prosthetic moiety of hemoglobi…
View article: Combined Phacoemulsification and Intravitreal anti-vascular endothelial growth factor(VEGF) versus Dexamethasone Implant in Diabetics with Coexisting Cataract and Centre-involving Diabetic Macular Edema
Combined Phacoemulsification and Intravitreal anti-vascular endothelial growth factor(VEGF) versus Dexamethasone Implant in Diabetics with Coexisting Cataract and Centre-involving Diabetic Macular Edema Open
Purpose: To compare the anatomical and functional outcome in groups who underwent combined phacoemulsification with intravitreal anti-vascular endothelial growth factor (VEGF) versus combined phacoemulsification with intravitreal dexametha…
View article: The Role of Sphingolipid Signaling in Oxidative Lung Injury and Pathogenesis of Bronchopulmonary Dysplasia
The Role of Sphingolipid Signaling in Oxidative Lung Injury and Pathogenesis of Bronchopulmonary Dysplasia Open
Premature infants are born with developing lungs burdened by surfactant deficiency and a dearth of antioxidant defense systems. Survival rate of such infants has significantly improved due to advances in care involving mechanical ventilati…
View article: Cortactin Modulates Lung Endothelial Apoptosis Induced by Cigarette Smoke
Cortactin Modulates Lung Endothelial Apoptosis Induced by Cigarette Smoke Open
Cigarette smoke (CS) is the primary cause of Chronic Obstructive Pulmonary Disease (COPD), and an important pathophysiologic event in COPD is CS-induced apoptosis in lung endothelial cells (EC). Cortactin (CTTN) is a cytoskeletal actin-bin…
View article: Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injury
Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injury Open
Introduction Neonatal lung injury as a consequence of hyperoxia (HO) therapy and ventilator care contribute to the development of bronchopulmonary dysplasia (BPD). Increased expression and activity of lysyl oxidase (LOX), a key enzyme that…
View article: NOX4 Mediates Pseudomonas aeruginosa-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium
NOX4 Mediates Pseudomonas aeruginosa-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium Open
Pseudomonas aeruginosa (PA) infection increases reactive oxygen species (ROS), and earlier, we have shown a role for NADPH oxidase-derived ROS in PA-mediated lung inflammation and injury. Here, we show a role for the lung epithelial cell (…