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View article: Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets
Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets Open
Type 1 diabetes (T1D) is an autoimmune disease caused by the loss of self-tolerance toward insulin-producing pancreatic β-cells. Its etiology remains incompletely understood but involves dysregulated T cell responses. Here, we perform sing…
View article: Cytogenetic anomalies are the predominant genetic alteration in children with nonfamilial tall stature: a comparative study with familial cases
Cytogenetic anomalies are the predominant genetic alteration in children with nonfamilial tall stature: a comparative study with familial cases Open
The purpose of this study is to elucidate the genetic causes and phenotypic presentation of nonfamilial tall stature (nFTS) and to compare these findings with those of familial tall stature (FTS) from the same population that was previousl…
View article: Association of Diabetic Ketoacidosis at Onset, Diabetes Technology Uptake, and Clinical Outcomes After 1 and 2 Years of Follow-up: A Collaborative Analysis of Pediatric Registries Involving 9,269 Children With Type 1 Diabetes From Nine Countries
Association of Diabetic Ketoacidosis at Onset, Diabetes Technology Uptake, and Clinical Outcomes After 1 and 2 Years of Follow-up: A Collaborative Analysis of Pediatric Registries Involving 9,269 Children With Type 1 Diabetes From Nine Countries Open
OBJECTIVE This study examined the association between diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis and long-term glycemic outcomes, insulin requirements, BMI SD score (SDS), and diabetes technology uptake in youth. RESEARCH DES…
View article: Monogenic causes of familial short stature
Monogenic causes of familial short stature Open
Genetic factors play a crucial role in determining human height. Short stature commonly affects multiple family members and therefore, familial short stature (FSS) represents a significant proportion of growth disorders. Traditionally, FSS…
View article: An imbalance of naïve and effector T-cell phenotypes in early type 1 diabetes across conventional and regulatory subsets
An imbalance of naïve and effector T-cell phenotypes in early type 1 diabetes across conventional and regulatory subsets Open
Type 1 diabetes (T1D) is an autoimmune disease caused by the loss of self-tolerance toward insulin-producing pancreatic β-cells. Although the etiology of T1D is not fully understood, it is linked to dysregulation of the T-cell compartment.…
View article: The role of dietary interventions in the prevention and management of type 1 diabetes
The role of dietary interventions in the prevention and management of type 1 diabetes Open
Vztah složení naší stravy a vzniku a léčby diabetes mellitus 1. typu (DM1) je znám již od dob před objevením inzulinu, kdy se poprvé objevila snaha pomocí dietních opatření zpomalit či zastavit progresi onemocnění. Kromě toho je k dietě př…
View article: Etiology of combined pituitary hormone deficiency: GNAO1 as a novel candidate gene
Etiology of combined pituitary hormone deficiency: GNAO1 as a novel candidate gene Open
Because the causes of combined pituitary hormone deficiency (CPHD) are complex, the etiology of congenital CPHD remains unknown in most cases. The aim of the study was to identify the genetic etiology of CPHD in a well-defined single-cente…
View article: Dietary Components in the Pathogenesis and Prevention of Type 1 Diabetes in Children
Dietary Components in the Pathogenesis and Prevention of Type 1 Diabetes in Children Open
Background: Type 1 diabetes (T1D) is a disease closely linked to nutrition and modifications in various dietary components have been part of the effort to prevent or slow the progression of the disease even before the discovery of insulin.…
View article: Why consider screening for preclinical stages of type 1 diabetes in children?
Why consider screening for preclinical stages of type 1 diabetes in children? Open
Diabetes 1. typu (DM1) patří mezi nejčastější chronická onemocnění dětského věku. Jeho incidence u nás dlouhodobě roste. U téměř třetiny z nově diagnostikovaných dětí je při diagnóze přítomna diabetická ketoacidóza (DKA) různého stupně záv…
View article: Immunotherapy options for type 1 diabetes in children and adolescents
Immunotherapy options for type 1 diabetes in children and adolescents Open
Diabetes 1. typu je autoimunní onemocnění, při kterém dochází k postupné destrukci beta buněk vedoucí k rozvoji diabetu. Imunoterapie si klade za cíl zastavit proces destrukce a předejít nebo modifikovat rychlost vzniku diabetu. V rámci kl…
View article: Are we ready to screen for type 1 diabetes? A structured worldwide survey among healthcare providers involved in paediatric diabetes care
Are we ready to screen for type 1 diabetes? A structured worldwide survey among healthcare providers involved in paediatric diabetes care Open
Type 1 diabetes (T1D) autoantibody screening is focused on detecting early stages of the disease. Until recently, the main goal of screening was to reduce the risk of diabetic ketoacidosis at T1D onset. However, recent approval of therapie…
View article: Genetic Testing of Children With Familial Tall Stature: Is it Worth Doing?
Genetic Testing of Children With Familial Tall Stature: Is it Worth Doing? Open
Context Familial tall stature (FTS) is considered to be a benign variant of growth with a presumed polygenic etiology. However, monogenic disorders with possible associated pathological features could also be hidden under the FTS phenotype…
View article: Are all HCL systems the same? long term outcomes of three HCL systems in children with type 1 diabetes: real-life registry-based study
Are all HCL systems the same? long term outcomes of three HCL systems in children with type 1 diabetes: real-life registry-based study Open
Objective To compare parameters of glycemic control among three types of hybrid closed loop (HCL) systems in children with T1D (CwD) using population-wide data from the national pediatric diabetes registry ČENDA. Methods CwD aged <19 ye…
View article: Analysis of children with familial short stature: who should be indicated for genetic testing?
Analysis of children with familial short stature: who should be indicated for genetic testing? Open
Familial short stature (FSS) describes vertically transmitted growth disorders. Traditionally, polygenic inheritance is presumed, but monogenic inheritance seems to occur more frequently than expected. Clinical predictors of monogenic FSS …
View article: Basal and Bolus Insulin Distribution According to Treatment Modality: Data from SWEET Diabetes Registry
Basal and Bolus Insulin Distribution According to Treatment Modality: Data from SWEET Diabetes Registry Open
Background and Aims. The optimal basal and bolus insulin distribution in type 1 diabetes (T1D) is still controversial. Herein, we aimed to determine the variability of basal to total daily insulin dose according to treatment modality and d…
View article: Glycemic Control by Treatment Modalities: National Registry-Based Population Data in Children and Adolescents with Type 1 Diabetes
Glycemic Control by Treatment Modalities: National Registry-Based Population Data in Children and Adolescents with Type 1 Diabetes Open
Introduction: The aim of the study was to assess the differences in key parameters of type 1 diabetes (T1D) control associated with treatment and monitoring modalities including newly introduced hybrid closed-loop (HCL) algorithm in childr…
View article: Isolated growth hormone deficiency in children with vertically transmitted short stature: What do the genes tell us?
Isolated growth hormone deficiency in children with vertically transmitted short stature: What do the genes tell us? Open
Introduction The growth hormone deficiency (GHD) diagnosis is controversial especially due to low specificity of growth hormone (GH) stimulation tests. It is therefore believed that children diagnosed with GHD form a heterogeneous group wi…
View article: Supplementary Material for: Glycemic control by treatment modalities: national registry-based population data in children and adolescents with type 1 diabetes
Supplementary Material for: Glycemic control by treatment modalities: national registry-based population data in children and adolescents with type 1 diabetes Open
AIMS To assess the differences in key parameters of type 1 diabetes (T1D) control associated with treatment and monitoring modalities including newly introduced hybrid closed-loop (HCL) algorithm in children and adolescents with T1D (CwD) …
View article: Low-Carbohydrate Diet among Children with Type 1 Diabetes: A Multi-Center Study
Low-Carbohydrate Diet among Children with Type 1 Diabetes: A Multi-Center Study Open
Aims/hypothesis: The proportion of children with type 1 diabetes (T1D) who have experience with low-carbohydrate diet (LCD) is unknown. Our goal was to map the frequency of LCD among children with T1D and to describe their clinical and lab…