Vitaly Ievlev
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View article: Transgenic ferret models define pulmonary ionocyte diversity and function
Transgenic ferret models define pulmonary ionocyte diversity and function Open
Speciation leads to adaptive changes in organ cellular physiology and creates challenges for studying rare cell-type functions that diverge between humans and mice. Rare cystic fibrosis transmembrane conductance regulator (CFTR)-rich pulmo…
View article: Orthotopic Ferret Tracheal Transplantation Using a Recellularized Bioengineered Graft Produces Functional Epithelia
Orthotopic Ferret Tracheal Transplantation Using a Recellularized Bioengineered Graft Produces Functional Epithelia Open
Tracheal grafts may be necessary to bridge long-segment defects after curative resection for airway obstructions. Bioengineered grafts have emerged as an appealing option, given the possibilities of altering the histologic and cellular pro…
View article: Development and characterization of ferret ex vivo tracheal injury and cell engraftment model
Development and characterization of ferret ex vivo tracheal injury and cell engraftment model Open
The field of airway biology research relies primarily on in vitro and in vivo models of disease and injury. The use of ex vivo models to study airway injury and cell-based therapies remains largely unexplored although such models have the …
View article: Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells
Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells Open
Keratin expression dynamically changes in airway basal cells (BCs) after acute and chronic injury, yet the functional consequences of these changes on BC behavior remain unknown. In bronchiolitis obliterans (BO) after lung transplantation,…
View article: Sox9 and Lef1 Regulate the Fate and Behavior of Airway Glandular Progenitors in Response to Injury
Sox9 and Lef1 Regulate the Fate and Behavior of Airway Glandular Progenitors in Response to Injury Open
Cartilaginous airways of larger mammals and the mouse trachea contain at least 3 well-established stem cell compartments, including basal cells of the surface airway epithelium (SAE) and ductal and myoepithelial cells of the submucosal gla…
View article: A Novel Bioreactor for Reconstitution of the Epithelium and Submucosal Glands in Decellularized Ferret Tracheas
A Novel Bioreactor for Reconstitution of the Epithelium and Submucosal Glands in Decellularized Ferret Tracheas Open
Tracheal grafts introduce the possibility to treat airway pathologies that require resection. While there has been success with engraftment of the surface airway epithelium (SAE) onto decellularized tracheas, there has been minimal advance…
View article: LEF-1 Controls Cell Cycle Progression in Airway Basal Cells to Regulate Proliferation and Differentiation
LEF-1 Controls Cell Cycle Progression in Airway Basal Cells to Regulate Proliferation and Differentiation Open
The mammalian airways are lined by a continuous epithelial layer that is maintained by diverse populations of resident multipotent stem cells. These stem cells are responsible for replenishing the epithelium both at homeostasis and followi…
View article: Functional Characterization of a Novel IRF6 Frameshift Mutation From a Van Der Woude Syndrome Family
Functional Characterization of a Novel IRF6 Frameshift Mutation From a Van Der Woude Syndrome Family Open
In this VWS pedigree, a novel frameshift of IRF6 was identified as the likely causative gene variant. It is a lost function mutation which could not rescue abnormal periderm phenotype in irf6 maternal-null zebrafish and which causes the pr…
View article: Programming of Cell Resistance to Genotoxic and Oxidative Stress
Programming of Cell Resistance to Genotoxic and Oxidative Stress Open
Different organisms, cell types, and even similar cell lines can dramatically differ in resistance to genotoxic stress. This testifies to the wide opportunities for genetic and epigenetic regulation of stress resistance. These opportunitie…