Vítor A. P. Martins dos Santos
YOU?
Author Swipe
View article: Towards an attitude of responsibility for safety in life science education
Towards an attitude of responsibility for safety in life science education Open
View article: Rhodo-Box: a Synthetic Biology Toolbox to Facilitate Metabolic Engineering of <i>Rhodobacter sphaeroides</i>
Rhodo-Box: a Synthetic Biology Toolbox to Facilitate Metabolic Engineering of <i>Rhodobacter sphaeroides</i> Open
Rhodobacter sphaeroides is a purple non-sulphur alphaproteobacterium with a highly versatile metabolism. This microorganism holds promise as a chassis for sustainable biomanufacturing of numerous chemicals. Yet, its potential is constraine…
View article: Valorising waste in biomanufacturing: Complexities of circularity, safety and sustainability
Valorising waste in biomanufacturing: Complexities of circularity, safety and sustainability Open
View article: Combinatorial engineering pinpoints shikimate pathway bottlenecks in para-aminobenzoic acid production in Pseudomonas putida
Combinatorial engineering pinpoints shikimate pathway bottlenecks in para-aminobenzoic acid production in Pseudomonas putida Open
View article: Establishing the ELIXIR Microbiome Community
Establishing the ELIXIR Microbiome Community Open
Microbiome research has grown substantially over the past decade in terms of the range of biomes sampled, identified taxa, and the volume of data derived from the samples. In particular, experimental approaches such as metagenomics, metaba…
View article: Engineering chimeric signaling proteins for microbial whole-cell biosensors: from design to deployment
Engineering chimeric signaling proteins for microbial whole-cell biosensors: from design to deployment Open
Microbial whole-cell biosensors (MWCBs) harness living cells to detect analytes and produce measurable outputs, enabling continuous, low-cost, and in situ sensing. Central to MWCB function are modular sensing architectures, which can be re…
View article: Synthetic Microbial Cocultivation for Targeted Production of Odd-Chain Carboxylates and Alcohols from Carbon Monoxide
Synthetic Microbial Cocultivation for Targeted Production of Odd-Chain Carboxylates and Alcohols from Carbon Monoxide Open
Microbial fermentation of syngas (CO, H2, CO2) using acetogens is a promising route for the revalorisation of one-carbon feedstocks. However, product diversification from syngas using pure cultures of these microorgan…
View article: Use of Hyperbaric Oxygen in Patients with Necrotizing Soft Tissue Infections: A Scandinavian Multicenter, Prospective, Observational Cohort
Use of Hyperbaric Oxygen in Patients with Necrotizing Soft Tissue Infections: A Scandinavian Multicenter, Prospective, Observational Cohort Open
ClinicalTrials.gov number NCT01790698.
View article: Controlling metabolic stability of food microbiome for stable indigenous liquor fermentation
Controlling metabolic stability of food microbiome for stable indigenous liquor fermentation Open
View article: Strategic redesign of the central metabolism in Pseudomonas putida boosts NADPH generation and product formation
Strategic redesign of the central metabolism in Pseudomonas putida boosts NADPH generation and product formation Open
The biotechnological synthesis of chemicals presents a greener and more sustainable alternative to traditional petrochemical processes. However, achieving titers, rates, and yields (TRY) allowing for economic competitiveness remains a sign…
View article: Scientific and public imaginations of xenobiology
Scientific and public imaginations of xenobiology Open
Increasingly complex biotechnology endeavours, such as creating 'unnatural' life, warrant societal discussions on their applications and embedding. We explore ways in which xenobiologists imagine their work and relate that to public views.…
View article: Addressing semantic ambiguity in biotechnology: Proposals from the European research infrastructure IBISBA
Addressing semantic ambiguity in biotechnology: Proposals from the European research infrastructure IBISBA Open
Driven by numerous scientific discoveries in biology in the second half of the last century, biotechnology is now set to play an important role as a driver for advanced manufacturing, leveraging the power of living organisms to produce a r…
View article: Computer-assisted multilevel optimization of malonyl-CoA availability in Pseudomonas putida
Computer-assisted multilevel optimization of malonyl-CoA availability in Pseudomonas putida Open
Malonyl-CoA is the major precursor for the biosynthesis of diverse industrially valuable products such as fatty acids/alcohols, flavonoids, and polyketides. However, its intracellular availability is limited in most microbial hosts, hamper…
View article: Steering fatty acid composition of yeast microbial oil via genetic modification and bioprocess adjustment
Steering fatty acid composition of yeast microbial oil via genetic modification and bioprocess adjustment Open
The increasing demand for palm oil has drastic effects on the ecosystem as its production is not sustainable. To that end, developing a sustainable alternative to fatty acids and oils is urgent and of utmost interest. Oils produced by olea…
View article: Enabling Access to Novel Bacterial Biosynthetic Potential From <scp>ONT</scp> Draft Genomic Data
Enabling Access to Novel Bacterial Biosynthetic Potential From <span>ONT</span> Draft Genomic Data Open
Natural products comprise a wide diversity of compounds with a range of biological activities, including antibiotics, anti‐inflammatory and anti‐tumoral molecules. However, we can only access a small portion of these compounds due to vario…
View article: RNA-based SIBR as a tool for post-transcriptional regulation
RNA-based SIBR as a tool for post-transcriptional regulation Open
View article: Increasing predictability in scale-up by multi-scale modelling of strain degeneration in upstream seed trains and repeated fed-batch production
Increasing predictability in scale-up by multi-scale modelling of strain degeneration in upstream seed trains and repeated fed-batch production Open
View article: ICEMAN: increasing conservation of energy by microorganisms
ICEMAN: increasing conservation of energy by microorganisms Open
View article: Redefining biosensor design: a modular platform for customized microbial sensors
Redefining biosensor design: a modular platform for customized microbial sensors Open
View article: Establishing microbial production of anisole
Establishing microbial production of anisole Open
View article: Shikimate pathway-dependent catabolism: enabling near-to-maximum production of aromatics
Shikimate pathway-dependent catabolism: enabling near-to-maximum production of aromatics Open
View article: Model-driven engineering of Cutaneotrichosporon oleaginosus ATCC 20509 for improved microbial oil production
Model-driven engineering of Cutaneotrichosporon oleaginosus ATCC 20509 for improved microbial oil production Open
View article: Integrative Omics reveals changes in the cellular landscape of peroxisome-deficient pex3 yeast cells
Integrative Omics reveals changes in the cellular landscape of peroxisome-deficient pex3 yeast cells Open
Peroxisomes are organelles that are crucial for cellular metabolism, but they also play important roles in non-metabolic processes such as signalling, stress response or antiviral defense. To uncover the consequences of peroxisome deficien…
View article: A snapshot of biomanufacturing and the need for enabling research infrastructure
A snapshot of biomanufacturing and the need for enabling research infrastructure Open
Biomanufacturing is crucial for the bioeconomy, with growing investment and attention from industries and governments. Over recent decades numerous biotech companies have been founded, and policies have increasingly prioritised sustainable…
View article: Response to Letter to Editor by A. Derbalah et al.: the role of automation in enhancing reproducibility and interoperability of PBPK models
Response to Letter to Editor by A. Derbalah et al.: the role of automation in enhancing reproducibility and interoperability of PBPK models Open
View article: Computer assisted multi-level optimization of malonyl-CoA availability in<i>Pseudomonas putida</i>
Computer assisted multi-level optimization of malonyl-CoA availability in<i>Pseudomonas putida</i> Open
Malonyl-CoA is the major precursor for the biosynthesis of diverse industrially valuable products such as fatty acids/alcohols, flavonoids, and polyketides. However, its intracellular availability is limited in most microbial hosts, hamper…
View article: Combining metabolic engineering and fermentation optimization to achieve cost-effective oil production by<i>Cutaneotrichosporon oleaginosus</i>
Combining metabolic engineering and fermentation optimization to achieve cost-effective oil production by<i>Cutaneotrichosporon oleaginosus</i> Open
Microbial oils, produced by oleaginous microorganisms, offer a sustainable alternative to plant-derived oils. Among these microorganisms, Cutaneotrichosporon oleaginosus attracts attention as a promising microbial cell factory for sustaina…
View article: Novel multi-omics deconfounding variational autoencoders can obtain meaningful disease subtyping
Novel multi-omics deconfounding variational autoencoders can obtain meaningful disease subtyping Open
Unsupervised learning, particularly clustering, plays a pivotal role in disease subtyping and patient stratification, especially with the abundance of large-scale multi-omics data. Deep learning models, such as variational autoencoders (VA…
View article: Making PBPK models more reproducible in practice
Making PBPK models more reproducible in practice Open
Systems biology aims to understand living organisms through mathematically modeling their behaviors at different organizational levels, ranging from molecules to populations. Modeling involves several steps, from determining the model purp…
View article: GenoMine: a CRISPR-Cas9-based kill switch for biocontainment of Pseudomonas putida
GenoMine: a CRISPR-Cas9-based kill switch for biocontainment of Pseudomonas putida Open
Synthetic genetic circuits have revolutionised our capacity to control cell viability by conferring microorganisms with programmable functionalities to limit survival to specific environmental conditions. Here, we present the GenoMine safe…