Vittoria Frattolillo
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View article: Artificial Intelligence and Precision Pharmacotherapy in Pediatrics: A New Paradigm in Therapeutic Decision-Making
Artificial Intelligence and Precision Pharmacotherapy in Pediatrics: A New Paradigm in Therapeutic Decision-Making Open
Artificial Intelligence (AI) and Precision Medicine represent foundational pillars for transforming pediatric healthcare, as children exhibit age-specific pharmacokinetic variations requiring highly personalized therapeutic approaches that…
View article: Targeting the Gut Microbiota in Pediatric Obesity: A Paradigm Shift in Prevention and Treatment? A Comprehensive Review
Targeting the Gut Microbiota in Pediatric Obesity: A Paradigm Shift in Prevention and Treatment? A Comprehensive Review Open
Pediatric obesity represents a growing global health challenge, closely associated with increased cardiometabolic risk and long-term adverse outcomes. Although lifestyle modifications remain the cornerstone of treatment, sustained success …
View article: Innovative Strategies to Reduce Exposure and Expression of the Major Cat Allergen Fel d 1
Innovative Strategies to Reduce Exposure and Expression of the Major Cat Allergen Fel d 1 Open
Background Fel d 1, the primary allergen produced by cats, is a glycoprotein found mainly in their salivary and sebaceous glands. Due to its small size and stability, it easily becomes airborne and adheres to surfaces, posing a persistent …
View article: Closing the Pediatric Divide: A Performance Analysis of the GPT-5 Family in Medical Diagnostics
Closing the Pediatric Divide: A Performance Analysis of the GPT-5 Family in Medical Diagnostics Open
A bstract Background Large Language Models (LLMs) have demonstrated significant potential in clinical medicine, but a persistent performance gap exists in the pediatric domain due to its unique complexities. This study provides the first c…
View article: The Role of Generative Artificial Intelligence in Pediatric Healthcare Professions Education: A Narrative Review
The Role of Generative Artificial Intelligence in Pediatric Healthcare Professions Education: A Narrative Review Open
The advent of generative artificial intelligence (GenAI), particularly Large Language Models (LLMs), presents transformative potential for pediatric healthcare professions education. This narrative review explores the current applications,…
View article: Zero-Shot Evaluation of Kimi K2 on Pediatric Clinical Cases
Zero-Shot Evaluation of Kimi K2 on Pediatric Clinical Cases Open
Background The application of large language models (LLMs) in pediatric medicine requires rigorous performance evaluation prior to clinical implementation. Objective To evaluate the accuracy of the Kimi K2 model in analyzing pediatric clin…
View article: Integrating digital health into pediatric obesity management: Current practices and future perspectives
Integrating digital health into pediatric obesity management: Current practices and future perspectives Open
View article: Artificial intelligence for solving pediatric clinical cases: A Retrieval-Augmented approach utilizing Llama3.2 and structured references
Artificial intelligence for solving pediatric clinical cases: A Retrieval-Augmented approach utilizing Llama3.2 and structured references Open
Incorporating RAG systems into clinical decision-making can enhance reliability and safety.
View article: Liver-Kidney Crosstalk in Major Pediatric Diseases: Unraveling the Complexities and Clinical Challenges
Liver-Kidney Crosstalk in Major Pediatric Diseases: Unraveling the Complexities and Clinical Challenges Open
The liver and kidneys are two of the most vital organs, each with distinct but overlapping functions essential for maintaining homeostasis. The complex interplay between these organs, commonly referred to as liver-kidney crosstalk, plays a…
View article: Synthetic Ultrasound Image Generation for Breast Cancer Diagnosis Using cVAE-WGAN Models: An Approach Based on Generative Artificial Intelligence
Synthetic Ultrasound Image Generation for Breast Cancer Diagnosis Using cVAE-WGAN Models: An Approach Based on Generative Artificial Intelligence Open
The scarcity and imbalance of medical image datasets hinder the development of robust computer-aided diagnosis (CAD) systems for breast cancer. This study explores the application of advanced generative models, based on generative artifici…
View article: ARE LLMS READY FOR PEDIATRICS? A COMPARATIVE EVALUATION OF MODEL ACCURACY ACROSS CLINICAL DOMAINS
ARE LLMS READY FOR PEDIATRICS? A COMPARATIVE EVALUATION OF MODEL ACCURACY ACROSS CLINICAL DOMAINS Open
A bstract Large Language Models (LLMs) are rapidly emerging as promising tools in the healthcare field, yet their effectiveness in pediatric contexts remains underexplored. This study evaluated the performance of eight contemporary LLMs, r…
View article: Bioinformatic Approach to Cross-Reactivity Between Dust Mites and Scabies Mites: Clinical and Molecular Implications
Bioinformatic Approach to Cross-Reactivity Between Dust Mites and Scabies Mites: Clinical and Molecular Implications Open
Cross-reactivity between house dust mites and scabies mites is a clinically significant but often underestimated phenomenon that can complicate both the management of respiratory allergies and the diagnosis of parasitic infections such as …
View article: Paliperidone-Induced Massive Asymptomatic Creatine Kinase Elevation in Youth: From a Case Report to Literature Review
Paliperidone-Induced Massive Asymptomatic Creatine Kinase Elevation in Youth: From a Case Report to Literature Review Open
Background/Objectives: Unlike rhabdomyolysis and neuroleptic malignant syndrome (NMS), massive asymptomatic creatine kinase elevation (MACKE) represents a condition commonly detected during routine screening in patients receiving antipsych…
View article: Artificial Intelligence in Pediatric Nail Diseases: Limitations and Prospects
Artificial Intelligence in Pediatric Nail Diseases: Limitations and Prospects Open
View article: Large language models performance on pediatrics question: a new challenge
Large language models performance on pediatrics question: a new challenge Open
View article: Naegleria fowleri, the “brain-eating amoeba”: an invisible enemy in nasal irrigation with untreated water
Naegleria fowleri, the “brain-eating amoeba”: an invisible enemy in nasal irrigation with untreated water Open
View article: Kidney Damage in Pediatric Obesity: Insights from an Emerging Perspective
Kidney Damage in Pediatric Obesity: Insights from an Emerging Perspective Open
The role of obesity as a risk factor for chronic kidney disease (CKD) in adulthood has been well established. Over the last years, kidney damage (KD) has emerged as a significant consequence of obesity since childhood. Indeed, a complex in…
View article: Jailbreaking large language models: navigating the crossroads of innovation, ethics, and health risks
Jailbreaking large language models: navigating the crossroads of innovation, ethics, and health risks Open
View article: Unveiling Artificial Intelligence’s Power: Precision, Personalization, and Progress in Rheumatology
Unveiling Artificial Intelligence’s Power: Precision, Personalization, and Progress in Rheumatology Open
This review examines the increasing use of artificial intelligence (AI) in rheumatology, focusing on its potential impact in key areas. AI, including machine learning (ML) and deep learning (DL), is revolutionizing diagnosis, treatment per…
View article: Cross-Reactions and Biomedical Innovations: Challenges and Prospects in Managing Pork-Cat Syndrome
Cross-Reactions and Biomedical Innovations: Challenges and Prospects in Managing Pork-Cat Syndrome Open
View article: AllergoAssist 2.0: a Specialized Artificial Intelligence for Pediatric Allergology
AllergoAssist 2.0: a Specialized Artificial Intelligence for Pediatric Allergology Open
View article: ChatGPT as a bioinformatic partner
ChatGPT as a bioinformatic partner Open
The advanced Large Language Model ChatGPT4o, developed by OpenAI, can be used in the field of bioinformatics to analyze and understand cross-reactive allergic reactions. This study explores the use of ChatGPT4o to support research on aller…
View article: Basal knowledge in the field of pediatric nephrology and its enhancement following specific training of ChatGPT-4 “omni” and Gemini 1.5 Flash
Basal knowledge in the field of pediatric nephrology and its enhancement following specific training of ChatGPT-4 “omni” and Gemini 1.5 Flash Open
Background We aimed to evaluate the baseline performance and improvement of ChatGPT-4 “omni” (ChatGPT-4o) and Gemini 1.5 Flash (Gemini 1.5) in answering multiple-choice questions related to pediatric nephrology after specific training. Met…