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View article: Tailoring ultrahigh index plasmonic combinatorial metamaterials for SEIRA and SERS by tuning the fill fraction
Tailoring ultrahigh index plasmonic combinatorial metamaterials for SEIRA and SERS by tuning the fill fraction Open
Plasmonic materials with strong mid-infrared resonances allow enhanced molecular sensing, but obtaining the required high field enhancements in easily constructed geometries is challenging. Multilayer aggregates (MLaggs) of close-packed go…
View article: Glycan site loss in two egg-adapted live attenuated influenza vaccine strains does not cause antigenic mismatches
Glycan site loss in two egg-adapted live attenuated influenza vaccine strains does not cause antigenic mismatches Open
The haemagglutinin (HA) proteins of contemporary human H3N2 influenza viruses are heavily glycosylated. Glycans influence the protein’s receptor-binding properties and antigenic profile and can be lost when candidate influenza vaccine stra…
View article: Insulin-degrading enzyme regulates insulin-directed cellular autoimmunity in murine type 1 diabetes
Insulin-degrading enzyme regulates insulin-directed cellular autoimmunity in murine type 1 diabetes Open
Type 1 diabetes results from the destruction of pancreatic beta cells by autoreactive T cells. As an autoantigen with extremely high expression in beta cells, insulin triggers and sustains the autoimmune CD4 + and CD8 + T cell responses an…
View article: An automated, low volume, and high-throughput analytical platform for aggregate quantitation from cell culture media
An automated, low volume, and high-throughput analytical platform for aggregate quantitation from cell culture media Open
High throughput screening methods have driven a paradigm shift in biopharmaceutical development by reducing the costs of good manufactured (COGM) and accelerate the launch to market of novel drug products. Scale-down cell culture systems s…
View article: Toward Rapid Aspartic Acid Isomer Localization in Therapeutic Peptides Using Cyclic Ion Mobility Mass Spectrometry
Toward Rapid Aspartic Acid Isomer Localization in Therapeutic Peptides Using Cyclic Ion Mobility Mass Spectrometry Open
There is an increasing emphasis on the critical evaluation of interbatch purity and physical stability of therapeutic peptides. This is due to concerns over the impact that product- and process-related impurities may have on safety and eff…
View article: Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales
Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales Open
Transgenic human monoclonal antibodies derived from humanized mice against different epitopes of the Middle East respiratory syndrome coronavirus (MERS-CoV), and chimeric llama-human bispecific heavy chain-only antibodies targeting the Rif…
View article: An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag
An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag Open
Bioconjugates are an important class of therapeutic molecules. To date, O-glycan-based metabolic glycoengineering has had limited use in this field, due to the complexities of the endogenous O-glycosylation pathway and the lack of an O-gly…
View article: Infrared absorbance spectroscopy of aqueous proteins: Comparison of transmission and ATR data collection and analysis for secondary structure fitting
Infrared absorbance spectroscopy of aqueous proteins: Comparison of transmission and ATR data collection and analysis for secondary structure fitting Open
Attenuated total reflectance (ATR) infrared absorbance spectroscopy of proteins in aqueous solution is much easier to perform than transmission spectroscopy, where short path‐length cells need to be assembled reproducibly. However, the sha…