Explanipedia

Sequential Multiple Assignment Randomized Treatment (SMART) for Bipolar Disorder at Any Phase of Illness and at least Mild Symptom Severity Open

Keming Gao, Jodi Gonzalez Arnold, Thomas J. Prihoda, Marlon P. Quinones, Vivek Singh , et al. · 2025

Objectives: To sequentially study the effectiveness of lithium and divalproex monotherapy and adjunctive therapy with quetiapine or lamotrigine in the acute and continuation treatment of bipolar I or II disorder at any phase of illness and…

Development of a Patient-Centered Software System to Facilitate Effective Management of Bipolar Disorder Open

Charles L. Bowden, H. Richard Priesmeyer, Mauricio Tohen, Vivek Singh, Joseph R. Calabrese , et al. · 2025

Objective: Self-management of bipolar disorder (BD) is an important component of treatment. Methods: We developed a patient-centered computational software system based on concepts from nonlinear systems (chaos) theory with mobile access t…

KIOS: A smartphone app for self‐monitoring for patients with bipolar disorder Open

Mehak Pahwa, Susan L. McElroy, H. Richard Priesmeyer, Gregg Siegel, Phyllis A. Siegel , et al. · 2023

Objectives This study examined the use of a self‐monitoring/self‐management smartphone application (app) for patients with bipolar disorder. The app was specifically designed with patient‐centered computational software system based on con…

Childhood trauma and treatment outcomes during mood‐stabilising treatment with lithium or quetiapine among outpatients with bipolar disorder Open

Anna Wrobel, Ole Köhler‐Forsberg, Louisa G. Sylvia, Samantha E. Russell, Olivia Dean , et al. · 2022

Background Childhood trauma affects the course of mood disorders. Researchers are now considering childhood trauma as an influential factor in the treatment of mood disorders. However, the role of childhood trauma in the treatment of bipol…

Response and remission rates during 24 weeks of mood-stabilizing treatment for bipolar depression depending on early non-response Open

Ole Köhler‐Forsberg, Kirstine H. Sloth, Louisa G. Sylvia, Michael E. Thase, Joseph R. Calabrese , et al. · 2021

Among patients with bipolar depression and non-response after 6 weeks treatment, representing an adequate bipolar depression trial, only one-third responded by 24 weeks. These results highlight the need for better treatment alternatives fo…

Temperament and character traits in patients with bipolar disorder and associations with comorbid alcoholism or anxiety disorders Open

Fabiano G. Nery, John P. Hatch, David C. Glahn, Mark Nicoletti, E. Serap Monkul , et al. · 2020

Temperament and character traits may determine differences in clinical presentations and outcome of bipolar disorder. We compared personality traits in bipolar patients and healthy individuals using the Temperament and Character Inventory …

Deconstructing major depressive episodes across unipolar and bipolar depression by severity and duration: a cross-diagnostic cluster analysis on a large, international, observational study Open

Filippo Corponi, Gerard Anmella, Isabella Pacchiarotti, Ludovic Samalin, Norma Verdolini , et al. · 2020

The anti-aging effects of lithium in lymphoblastoid cell lines from patients with bipolar disorder and controls Open

Gabriel R. Fries, Madeline J. Zamzow, Gabriela Delevati Colpo, Nancy Monroy‐Jaramillo, João Quevedo , et al. · 2020

The role of different patterns of psychomotor symptoms in major depressive episode: Pooled analysis of the BRIDGE and BRIDGE‐II‐MIX cohorts Open

Margherita Barbuti, Cecilia Mainardi, Isabella Pacchiarotti, Norma Verdolini, Giuseppe Maccariello , et al. · 2019

Background Psychomotor agitation (PA) or retardation (PR) during major depressive episodes (MDEs) have been associated with depression severity in terms of treatment‐resistance and course of illness. Objectives We investigated the possible…

Patterns of changes in bipolar depressive symptoms revealed by trajectory analysis among 482 patients with bipolar disorder Open

Ida Behrendt‐møller, Trine Madsen, Holger J. Sørensen, Louisa G. Sylvia, Edward S. Friedman , et al. · 2018

Introduction Depressive episodes are often prevalent among patients with bipolar disorder, but little is known regarding the differential patterns of development over time. We aimed to determine and characterize trajectories of depressive …

Multistate Outcome and Persistent Benefit Analysis in Bipolar Mood Disorders Open

Charles L. Bowden · 2018

Patient with major depressive episode meeting DSMIV criteria. Patient age first psychiatric symptoms, age first depression, postpartum depression, suicidal attempts, seasonality of mood episodes, in the past, response to antidepressants,15…

Are traditional approaches diminishing the bipolar drug pipeline? Open

Charles L. Bowden, Melissa Martínez · 2018

KEYWORDS: Bipolar disorderbipolar inventory symptom scale (BISS)symptom domainsmulti-state outcome analysis of treatment (MOAT)

Is recurrence in major depressive disorder related to bipolarity and mixed features? Results from the BRIDGE-II-Mix study Open

Lorenzo Mazzarini, Georgios D. Kotzalidis, Daria Piacentino, Salvatore Rizzato, Jules Angst , et al. · 2018

Distinct lithium-induced gene expression effects in lymphoblastoid cell lines from patients with bipolar disorder Open

Gabriel R. Fries, Gabriela Delevati Colpo, Nancy Monroy‐Jaramillo, Junfei Zhao, Zhongming Zhao , et al. · 2017

Aggressiveness in depression: a neglected symptom possibly associated with bipolarity and mixed features Open

Norma Verdolini, Giulio Perugi, Ludovic Samalin, Andréa Murru, Jules Angst , et al. · 2017

Objective To evaluate aggressiveness during a major depressive episode ( MDE ) and its relationship with bipolar disorder ( BD ) in a post hoc analysis of the BRIDGE ‐ II ‐ MIX study. Method A total of 2811 individuals were enrolled in thi…

Obesity in patients with major depression is related to bipolarity and mixed features: evidence from the BRIDGE‐II‐Mix study Open

Eleonora Petri, Olivia Bacci, Margherita Barbuti, Isabella Pacchiarotti, Jean‐Michel Azorin , et al. · 2017

Objectives The Bipolar Disorders: Improving Diagnosis, Guidance and Education (BRIDGE) ‐ II ‐ Mix study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions. T…

Conference Committee Open

Manuel Sánchez de Carmona, Steering Committee, Mark A. Frye, Trisha Suppes, Willem A. Nolen , et al. · 2017

Integrated transcriptome and methylome analysis in youth at high risk for bipolar disorder: a preliminary analysis Open

Gabriel R. Fries, João Quevedo, Cristian Zeni, Iram Kazimi, Giovana Zunta‐Soares , et al. · 2017

Depression and Anxiety Issue Information Open

Maria M. Steenkamp, Esther Blessing, Isaac R. Galatzer‐Levy, Laura Hollahan, William D. Anderson , et al. · 2017

Poor quality of life and functioning in bipolar disorder Open

Louisa G. Sylvia, Rebecca E. Montana, Thilo Deckersbach, Michael E. Thase, Maurcio Tohen , et al. · 2017

Background This study explores the association of demographic and clinical features with quality of life and functioning in individuals with bipolar disorder. Methods Adult participants ( N = 482) with bipolar I or II disorder were enrolle…

Nonsteroidal anti-inflammatory drugs (NSAIDs) and paracetamol do not affect 6-month mood-stabilizing treatment outcome among 482 patients with bipolar disorder Open

Ole Köhler‐Forsberg, Louisa G. Sylvia, Michael E. Thase, Joseph R. Calabrese, Thilo Deckersbach , et al. · 2017

This is the first trial to show that use of NSAIDs and paracetamol, alone or in combination, does not affect lithium- or quetiapine-based bipolar disorder mood-stabilizing treatment outcomes. Prior studies have suggested that NSAIDs may in…

White blood cell count correlates with mood symptom severity and specific mood symptoms in bipolar disorder Open

Ole Köhler‐Forsberg, Louisa G. Sylvia, Charles L. Bowden, Joseph R. Calabrese, Michael E. Thase , et al. · 2016

Objective: Immune alterations may play a role in bipolar disorder etiology; however, the relationship between overall immune system functioning and mood symptom severity is unknown. Methods: The two comparative effectiveness trials, the Cl…

A tool to predict suicidal ideation and behavior in bipolar disorder: The Concise Health Risk Tracking Self-Report Open

Noreen A. Reilly-Harrington, Richard C. Shelton, Masoud Kamali, Dustin J. Rabideau, Leah W. Shesler , et al. · 2015

A clinical measure of suicidal ideation, suicidal behavior, and associated symptoms in bipolar disorder: Psychometric properties of the Concise Health Risk Tracking Self-Report (CHRT-SR) Open

Michael J. Ostacher, Andrew A. Nierenberg, Dustin J. Rabideau, Noreen A. Reilly-Harrington, Louisa G. Sylvia , et al. · 2015

Providing assessable information on effectiveness of maintenance treatments for bipolar disorder to psychiatrists and patients Open

Charles L. Bowden · 2015

FROM: Miura T, Noma H, Furukawa TA , et al . Comparative efficacy and tolerability of pharmacological treatments in the maintenance treatment of bipolar disorder: a systematic review and network meta-analysis. Lancet Psychiatry 2014;1:351–…

Multi-state outcome analysis of treatments (MOAT): application of a new approach to evaluate outcomes in longitudinal studies of bipolar disorder Open

Charles L. Bowden, Jim Mintz, Mauricio Tohen · 2015

Survival analyzes are usually based on a single point in time predefined event. Dissatisfied with this approach to evaluating maintenance treatment outcomes, we developed the Multi-state Outcome Analysis of Treatments (MOAT) methodology us…

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