Vivek Singh
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View article: 4D Bioprinting of Self‐Morphed Corneal Equivalents Using Smart Hybrid Hydrogels
4D Bioprinting of Self‐Morphed Corneal Equivalents Using Smart Hybrid Hydrogels Open
The curvature of the cornea is intrinsically linked to its topographical features, which are critical determinants of its optical and mechanical performance. While conventional bioprinting enables the fabrication of static, complex geometr…
View article: A88 Balloon-assisted coiling of intracranial aneurysms: technical details and evaluation of local complications
A88 Balloon-assisted coiling of intracranial aneurysms: technical details and evaluation of local complications Open
View article: Evaluating the potential of travoprost-thymoquinone co-loaded liposomes: a glaucomatous rabbit model study
Evaluating the potential of travoprost-thymoquinone co-loaded liposomes: a glaucomatous rabbit model study Open
The optimized formulation demonstrated a vesicle size of 96.02 ± 1.35 nm having negative surface charge encapsulated 81.55 ± 1.12% of TQ and 86.88 ± 0.55% of TP. LP-TP-TQ released drug sustained for 24 hr, while ex vivo permeation studies …
View article: AURA-CVC: Autonomous Ultrasound-guided Robotic Assistance for Central Venous Catheterization
AURA-CVC: Autonomous Ultrasound-guided Robotic Assistance for Central Venous Catheterization Open
Purpose: Central venous catheterization (CVC) is a critical medical procedure for vascular access, hemodynamic monitoring, and life-saving interventions. Its success remains challenging due to the need for continuous ultrasound-guided visu…
View article: Emerging approaches for ocular surface and corneal stromal regeneration: Recent advances and future perspectives
Emerging approaches for ocular surface and corneal stromal regeneration: Recent advances and future perspectives Open
Corneal blindness affects millions worldwide, with a particularly high burden in developing regions, especially in Asia and Africa. In India, the scarcity of donor corneal tissue and challenges in post-transplant care complicate efforts to…
View article: The Human Cornea: Unraveling Its Structural, Chemical, and Biochemical Complexities
The Human Cornea: Unraveling Its Structural, Chemical, and Biochemical Complexities Open
The cornea, the transparent part of the anterior eye, is vital for light refraction and vision. This review examines the intricate chemical and biochemical interactions essential for maintaining corneal transparency and highlights signific…
View article: Age dependence of the average refractive index of the isolated human crystalline lens
Age dependence of the average refractive index of the isolated human crystalline lens Open
We measured the average group refractive index (RI) of 120 isolated lenses from 120 human donors (age: 0.03 to 61 years). The average group RI was calculated from a measurement of the optical thickness of the lens using optical coherence t…
View article: Measuring Electron Energy in Muon-to-Electron Conversion using Holographic Synchrotron Radiation Emission Spectroscopy
Measuring Electron Energy in Muon-to-Electron Conversion using Holographic Synchrotron Radiation Emission Spectroscopy Open
The coherent conversion of a muon to an electron in a nuclear field has been one of the most powerful methods for searching for charged lepton flavor violation. Recent advancements have significantly enhanced the sensitivity of $μ\rightarr…
View article: Neutrophil‐driven and interleukin‐36γ‐associated ocular surface inflammation in chronic Stevens–Johnson syndrome
Neutrophil‐driven and interleukin‐36γ‐associated ocular surface inflammation in chronic Stevens–Johnson syndrome Open
Purpose This study aims to elucidate the tear proteome and understand the underlying molecular mechanisms involved in the ocular complications following Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Methods Mass spectromet…
View article: Acidic hydrolytic stability of the Lifitegrast: Degradation, Method development, Validation, Synthesis, LC-MS/NMR Characterization, In silico and In vitro cytotoxicity
Acidic hydrolytic stability of the Lifitegrast: Degradation, Method development, Validation, Synthesis, LC-MS/NMR Characterization, In silico and In vitro cytotoxicity Open
In addition to the multiple vision problems, the toxicity of the degradation products of ophthalmic medications on eye health is today’s concern. Hence, degradation studies of ophthalmic drug and toxicity establishment of the degradation p…
View article: Clinical Profile and Outcomes of Patients Presenting with Upper Gastrointestinal Bleed and the Role of Early Endoscopy
Clinical Profile and Outcomes of Patients Presenting with Upper Gastrointestinal Bleed and the Role of Early Endoscopy Open
PRIMARY OBJECTIVES: To determine the various presentations, common etiological factors, site of lesion in cases of UGIB in urban population at a tertiary care hospital in western India. To determine the role of early endoscopy and endother…
View article: Current concepts in the management of cataract with keratoconus
Current concepts in the management of cataract with keratoconus Open
This review analyzed all pertinent articles on keratoconus (KCN) and cataract surgery. It covers preoperative planning, intraoperative considerations, and postoperative management, with the aim of providing a simplified overview of treatin…
View article: Comparative study between external and endoscopic Dacryocystorhinostomy
Comparative study between external and endoscopic Dacryocystorhinostomy Open
Background: Dacryocystorhinostomy (DCR) consists of creating a lacrimal drainage pathway to the nasal cavity to restore permanent drainage of previously obstructed excreting system.Materials and Methods: Study was conducted for 18 months d…
View article: Keratoconus in India: Clinical presentation and demographic distribution based on big data analytics
Keratoconus in India: Clinical presentation and demographic distribution based on big data analytics Open
Purpose: This paper aims to describe the clinical presentation and demographic distribution of keratoconus (KCN) in India by analyzing the electronic medical records (EMR) of patients presenting at a multitier ophthalmology hospital networ…
View article: Towards Establishing Dense Correspondence on Multiview Coronary Angiography: From Point-to-Point to Curve-to-Curve Query Matching
Towards Establishing Dense Correspondence on Multiview Coronary Angiography: From Point-to-Point to Curve-to-Curve Query Matching Open
Coronary angiography is the gold standard imaging technique for studying and diagnosing coronary artery disease. However, the resulting 2D X-ray projections lose 3D information and exhibit visual ambiguities. In this work, we aim to establ…
View article: Human cornea-derived extracellular matrix hydrogel for prevention of post-traumatic corneal scarring: A translational approach
Human cornea-derived extracellular matrix hydrogel for prevention of post-traumatic corneal scarring: A translational approach Open
Corneal scarring and opacification are a significant cause of blindness affecting millions worldwide. The current standard of care for corneal blindness is corneal transplantation, which suffers from several drawbacks. One alternative appr…
View article: Human Lacrimal Gland Derived Mesenchymal Stem Cells – Isolation, Propagation, and Characterization
Human Lacrimal Gland Derived Mesenchymal Stem Cells – Isolation, Propagation, and Characterization Open
This study reveals the first-time evidence for the presence of MSC population within the human LGs, and these cells might play a role in maintaining healthy microenvironment within normal LG and repair in diseased LGs.
View article: Correction to: identification and in silico analysis of a spectrum of SLC4A11 variations in indian familial and sporadic cases of congenital hereditary endothelial dystrophy
Correction to: identification and in silico analysis of a spectrum of SLC4A11 variations in indian familial and sporadic cases of congenital hereditary endothelial dystrophy Open
View article: IMMUNOHISTOCHEMICAL EVALUATION OF ESTROGENRECEPTOR AND PROGESTERONERECEPTOR IN UTERINESMOOTH MUSCLE CELLTUMORS
IMMUNOHISTOCHEMICAL EVALUATION OF ESTROGENRECEPTOR AND PROGESTERONERECEPTOR IN UTERINESMOOTH MUSCLE CELLTUMORS Open
Objective: To study the histo-morphological spectrum of uterine smooth cell tumors withimmunohistochemical expression of estrogen and progesterone receptor and to compare theirexpression with respect to that of surrounding myometrium. Mate…
View article: Expansion and characterization of human limbus-derived stromal/mesenchymal stem cells in xeno-free medium for therapeutic applications
Expansion and characterization of human limbus-derived stromal/mesenchymal stem cells in xeno-free medium for therapeutic applications Open
View article: Optimization and evaluation of tear protein elution from Schirmer’s strips in dry eye disease
Optimization and evaluation of tear protein elution from Schirmer’s strips in dry eye disease Open
Purpose: Extraction of tear protein from Schirmer’s strip is a prerequisite for the proper identification and screening of biomarkers in dry eye disease. The study compares different methods of extraction of tear proteins from the Schirmer…
View article: Newer approaches to dry eye therapy: Nanotechnology, regenerative medicine, and tissue engineering
Newer approaches to dry eye therapy: Nanotechnology, regenerative medicine, and tissue engineering Open
Definitive treatment of dry eye disease (DED), one of the commonest ocular surface disorders, has remained elusive despite several recent advances in better diagnostics and the introduction of newer therapeutic molecules. The current treat…
View article: Pre-Clinical Evaluation of Efficacy and Safety of Human Limbus-Derived Stromal/Mesenchymal Stem Cells with and without Alginate Encapsulation for Future Clinical Applications
Pre-Clinical Evaluation of Efficacy and Safety of Human Limbus-Derived Stromal/Mesenchymal Stem Cells with and without Alginate Encapsulation for Future Clinical Applications Open
Corneal opacification or scarring is one of the leading causes of blindness worldwide. Human limbus-derived stromal/mesenchymal stem cells (hLMSCs) have the potential of clearing corneal scarring. In the current preclinical studies, we aim…
View article: Fish hook technique for nucleus management in manual small-incision cataract surgery
Fish hook technique for nucleus management in manual small-incision cataract surgery Open
Manual small-incision cataract surgery (MSICS) preserves its utility as a cost-effective and efficient strategy for mitigating cataract-associated blindness. Numerous techniques of nucleus delivery in MSICS have been described in the liter…
View article: Recent Advancements in Molecular Therapeutics for Corneal Scar Treatment
Recent Advancements in Molecular Therapeutics for Corneal Scar Treatment Open
The process of corneal wound healing is complex and induces scar formation. Corneal scarring is a leading cause of blindness worldwide. The fibrotic healing of a major ocular wound disrupts the highly organized fibrillar collagen arrangeme…
View article: Identification and in silico analysis of a spectrum of SLC4A11 variations in Indian familial and sporadic cases of congenital hereditary endothelial dystrophy
Identification and in silico analysis of a spectrum of SLC4A11 variations in Indian familial and sporadic cases of congenital hereditary endothelial dystrophy Open
View article: Impact of teleconsultation on visual and refractive outcomes in patients undergoing laser refractive surgery during COVID-19
Impact of teleconsultation on visual and refractive outcomes in patients undergoing laser refractive surgery during COVID-19 Open
Purpose: To assess the role of remote teleconsultation (TC) follow-up care following a successful and uneventful laser vision correction. Methods: The study is a retrospective, comparative analysis of patients undergoing laser vision corre…
View article: Transcriptomic Profiling of Human Limbus-Derived Stromal/Mesenchymal Stem Cells—Novel Mechanistic Insights into the Pathways Involved in Corneal Wound Healing
Transcriptomic Profiling of Human Limbus-Derived Stromal/Mesenchymal Stem Cells—Novel Mechanistic Insights into the Pathways Involved in Corneal Wound Healing Open
Limbus-derived stromal/mesenchymal stem cells (LMSCs) are vital for corneal homeostasis and wound healing. However, despite multiple pre-clinical and clinical studies reporting the potency of LMSCs in avoiding inflammation and scarring dur…
View article: New Frontier in the Management of Corneal Dystrophies: Basics, Development, and Challenges in Corneal Gene Therapy and Gene Editing
New Frontier in the Management of Corneal Dystrophies: Basics, Development, and Challenges in Corneal Gene Therapy and Gene Editing Open
Corneal dystrophies represent a group of heterogeneous hereditary disorders causing progressive corneal opacification and blindness. Current corneal transplant management for corneal dystrophies faces the challenges of repeated treatments,…
View article: Endovascular Management of Vascular Complications in Renal Allograft - An Observational Study
Endovascular Management of Vascular Complications in Renal Allograft - An Observational Study Open
Context: Role of endovascular management of vascular complications in renal transplant recipients. Aims: To present our experience in endovascular management of vascular complications in renal transplant recipients with a literature review…