Vivek Mahadevan
YOU?
Author Swipe
View article: Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution
Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution Open
Decades of studies implicating GluN3A N-methyl-D-aspartate receptor (NMDAR) subunits in physiological and pathological function have largely been interpreted through direct regulation of conventional glutamatergic NMDARs. However, emerging…
View article: Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution
Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution Open
Summary Decades of studies implicating GluN3A N -methyl-D-aspartate receptor (NMDAR) subunits in physiological and pathological function have largely been interpreted through direct regulation of conventional glutamatergic NMDARs. However,…
View article: DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells
DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells Open
View article: Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development
Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development Open
SUMMARY Within the adult rodent hippocampus, opioids suppress inhibitory parvalbumin-expressing interneurons (PV-INs), thus disinhibiting local micro-circuits. However, it is unknown if this disinhibitory motif is conserved in other cortic…
View article: Divergent Opioid-Mediated Suppression of Inhibition between Hippocampus and Neocortex Across Species and Development
Divergent Opioid-Mediated Suppression of Inhibition between Hippocampus and Neocortex Across Species and Development Open
View article: NMDARs Drive the Expression of Neuropsychiatric Disorder Risk Genes Within GABAergic Interneuron Subtypes in the Juvenile Brain
NMDARs Drive the Expression of Neuropsychiatric Disorder Risk Genes Within GABAergic Interneuron Subtypes in the Juvenile Brain Open
Medial ganglionic eminence (MGE)-derived parvalbumin (PV)+, somatostatin (SST)+and Neurogliaform (NGFC)-type cortical and hippocampal interneurons, have distinct molecular, anatomical, and physiological properties. However, the molecular m…
View article: Emergence of non-canonical parvalbumin-containing interneurons in hippocampus of a murine model of type I lissencephaly
Emergence of non-canonical parvalbumin-containing interneurons in hippocampus of a murine model of type I lissencephaly Open
Type I lissencephaly is a neuronal migration disorder caused by haploinsuffiency of the PAFAH1B1 (mouse: Pafah1b1 ) gene and is characterized by brain malformation, developmental delays, and epilepsy. Here, we investigate the impact of Paf…
View article: Author response: Emergence of non-canonical parvalbumin-containing interneurons in hippocampus of a murine model of type I lissencephaly
Author response: Emergence of non-canonical parvalbumin-containing interneurons in hippocampus of a murine model of type I lissencephaly Open
Article Figures and data Abstract Introduction Results and discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Type I lissencephaly is a neuronal mig…
View article: Emergence of Non-Canonical Parvalbumin-Containing Interneurons in Hippocampus of a Murine Model of Type I Lissencephaly
Emergence of Non-Canonical Parvalbumin-Containing Interneurons in Hippocampus of a Murine Model of Type I Lissencephaly Open
Type I lissencephaly is a neuronal migration disorder caused by haploinsuffiency of the LIS1 gene and is characterized in humans by agyria, mislamination of brain structures, developmental delays, and epilepsy. Here, we investigate the imp…
View article: NMDAR-mediated transcriptional control of gene expression during the development of medial ganglionic eminence-derived interneurons
NMDAR-mediated transcriptional control of gene expression during the development of medial ganglionic eminence-derived interneurons Open
Medial ganglionic eminence (MGE)-derived parvalbumin (PV)+, somatostatin (SST)+ and Neurogliaform (NGFC)-type cortical and hippocampal interneurons, have distinct molecular, anatomical and physiological properties. However, the molecular m…
View article: Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells
Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells Open
The ability to modulate the efficacy of synaptic communication between neurons constitutes an essential property critical for normal brain function. Animal models have proved invaluable in revealing a wealth of diverse cellular mechanisms …
View article: Author response: Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells
Author response: Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The ability to modulate the efficacy of sy…
View article: Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells
Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells Open
The ability to modulate the efficacy of synaptic communication between neurons constitutes an essential property critical for normal brain function. Animal models have proved invaluable in revealing a wealth of diverse cellular mechanisms …
View article: Translatome Analyses Using Conditional Ribosomal Tagging in GABAergic Interneurons and Other Sparse Cell Types
Translatome Analyses Using Conditional Ribosomal Tagging in GABAergic Interneurons and Other Sparse Cell Types Open
GABAergic interneurons comprise a small but diverse subset of neurons in the mammalian brain that tightly regulate neuronal circuit maturation and information flow and, ultimately, behavior. Because of their centrality in the etiology of n…
View article: Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit
Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit Open
γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mature brain but has the paradoxical property of depolarizing neurons during early development. Depolarization provided by GABAA transmission during this …
View article: What biologists want from their chloride reporters – a conversation between chemists and biologists
What biologists want from their chloride reporters – a conversation between chemists and biologists Open
Impaired chloride transport affects diverse processes ranging from neuron excitability to water secretion, which underlie epilepsy and cystic fibrosis, respectively. The ability to image chloride fluxes with fluorescent probes has been ess…
View article: Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit
Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit Open
GABA is the main inhibitory neurotransmitter in the mature brain but has the paradoxical property of depolarizing neurons during early development. Depolarization provided by GABA A transmission during this early phase regulates neural ste…
View article: Neocortical Projection Neurons Instruct Inhibitory Interneuron Circuit Development in a Lineage-Dependent Manner
Neocortical Projection Neurons Instruct Inhibitory Interneuron Circuit Development in a Lineage-Dependent Manner Open
View article: Ionotropic and metabotropic kainate receptor signalling regulates Cl<sup>−</sup> homeostasis and GABAergic inhibition
Ionotropic and metabotropic kainate receptor signalling regulates Cl<sup>−</sup> homeostasis and GABAergic inhibition Open
Key points Potassium‐chloride co‐transporter 2 (KCC2) plays a critical role in regulating chloride homeostasis, which is essential for hyperpolarizing inhibition in the mature nervous system. KCC2 interacts with many proteins involved in e…
View article: Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model
Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model Open
Significance Huntington’s disease (HD) is a fatal neurodegenerative disorder that currently has no cure. Although HD is classically considered a motor disorder, HD patients experience learning and memory deficits years before the onset of …
View article: Emerging Mechanisms Underlying Dynamics of GABAergic Synapses
Emerging Mechanisms Underlying Dynamics of GABAergic Synapses Open
Inhibitory circuits are diverse, yet with a poorly understood cell biology. Functional characterization of distinct inhibitory neuron subtypes has not been sufficient to explain how GABAergic neurotransmission sculpts principal cell activi…
View article: Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition
Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition Open
KCC2 is a neuron-specific K+-Cl– cotransporter essential for establishing the Cl- gradient required for hyperpolarizing inhibition in the central nervous system (CNS). KCC2 is highly localized to excitatory synapses where it regulates spin…
View article: Author response: Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition
Author response: Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract KCC2 is a neuron-specific K+-…
View article: Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition
Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition Open
Although Netos are considered auxiliary subunits critical for kainate receptor (KAR) function, direct evidence for their regulation of native KARs is limited. Because Neto KAR regulation is GluK subunit/Neto isoform specific, such regulati…
View article: Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition
Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition Open
KCC2 is a neuron-specific K + -Cl − cotransporter essential for establishing the Cl − gradient required for hyperpolarizing inhibition. KCC2 is highly localized to excitatory synapses where it regulates spine morphogenesis and AMPA recepto…
View article: Author Index
Author Index Open
View article: A kainate receptor subunit promotes the recycling of the neuron-specific K+-Cl− co-transporter KCC2 in hippocampal neurons
A kainate receptor subunit promotes the recycling of the neuron-specific K+-Cl− co-transporter KCC2 in hippocampal neurons Open
View article: Regulation of neuronal chloride homeostasis by neuromodulators
Regulation of neuronal chloride homeostasis by neuromodulators Open
KCC2 is the central regulator of neuronal Cl − homeostasis, and is critical for enabling strong hyperpolarizing synaptic inhibition in the mature brain. KCC2 hypofunction results in decreased inhibition and increased network hyperexcitabil…
View article: Regulation of neuronal Cl- homeostasis and GABAergic inhibition by components of excitatory neurotransmission
Regulation of neuronal Cl- homeostasis and GABAergic inhibition by components of excitatory neurotransmission Open
KCC2 is the neuron-specific member of the K+-Cl- cotransporter family of proteins, which maintains a low intracellular Cl− essential for fast inhibitory synaptic transmission in the mature central nervous system (CNS). KCC2 is essential fo…
View article: Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures
Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures Open
Neto2 is a transmembrane protein that interacts with the neuron-specific K(+)-Cl(-) cotransporter (KCC2) in the central nervous system (CNS). Efficient KCC2 transport is essential for setting the neuronal Cl(-) gradient, which is required …