Explanipedia

Histomorphological Changes in Breast Lesions: A Retrospective Observational Study Open

Pushpak Chaudhari, Shanu Srivastav, Shilpa Gupta, Naureen Syed, Vivek Sanker , et al. · 2025

Background Breast lesions can occur in individuals of all age groups and may include a range of conditions, from benign abnormalities to malignant tumors. Among these, breast cancer is one of the most frequently diagnosed cancers worldwide…

Applications and Performance of Artificial Intelligence in Spinal Metastasis Imaging: A Systematic Review Open

Vivek Sanker, Poorvikha Gowda, Alexander Thaller, Zhikai Li, Philip Heesen , et al. · 2025

Background: Spinal metastasis is the third most common site for metastatic localization, following the lung and liver. Manual detection through imaging modalities such as CT, MRI, PET, and bone scintigraphy can be costly and inefficient. P…

Artificial Intelligence Models for Predicting Outcomes in Spinal Metastasis: A Systematic Review and Meta-Analysis Open

Vivek Sanker, Prachi Dawer, Alexander Thaller, Zhikai Li, Philip Heesen , et al. · 2025

Background: Spinal metastases can cause significant impairment of neurological function and quality of life. Hence, personalized clinical decision-making based on prognosis and likely outcome is desirable. The effectiveness of AI in predic…

RDTA-01 NAVIGATING THE THALAMUS: ROLE OF STEREOTACTIC RADIOSURGERY IN THE MANAGEMENT OF BRAIN METASTASES - A RETROSPECTIVE STUDY FROM A SINGLE INSTITUTION Open

Ahed H Kattaa, Jae‐Hyun Park, Amit Persad, Rodas Asrat Kassu, Santosh Guru , et al. · 2025

BACKGROUND Thalamus, known as the neural processor and integrator for forebrain activities, is an uncommon site for metastatic lesions. Stereotactic radiosurgery has become a key non-invasive treatment for BM. This study aims to assess the…

Artificial Intelligence for Non-Invasive Prediction of Molecular Signatures in Spinal Metastases: A Systematic Review Open

Vivek Sanker, Sai Sanikommu, Alexander Thaller, Zhikai Li, Philip Heesen , et al. · 2025

Background: Spinal metastases (SMs) are associated with poor prognosis and significant morbidity. We hypothesize that artificial intelligence (AI) models can enhance the identification and clinical utility of genetic and molecular signatur…

Exoscope-Assisted Spine Surgery: A Systematic Review From Basic to Complex Pathologies Open

Vivek Sanker, Vamshi Krishna Dv, Prachi Dawer, Tirth Dave, Tanvi Banjan , et al. · 2025

Operative neurosurgery has greatly benefited from technological advancements over the past several decades. However, challenges such as limited visualization, intraoperative navigation difficulties, and the complexity of spinal anatomy con…

Comparative Analysis Between Cortical Bone Trajectory (CBT) Screw Fixation and Traditional Pedicle Screw Fixation in Lumbar Spine Surgery: A Systematic Review and Meta-Analysis Open

Vivek Sanker, Amr Badary, Aliza Asad, Barabara Buccilli, Ahed H Kattaa , et al. · 2025

Cortical bone trajectory (CBT) screw fixation has been proposed as an alternative method to pedicle screw (PS) fixation for lumbar instrumented fusion. However, the benefits of this technique remain controversial. We searched PubMed, Scopu…

Patient-specific 3D reconstruction models for sacral tumor resection: illustrative cases. Open

Vivek Sanker, Aneysis D. Gonzalez-Suarez, N. Innocenti, María José Cavagnaro, Ikchan Jeon , et al. · 2025

Surgical planning and execution have clearly advanced significantly with the introduction of 3D modeling into spine surgery. Based on the authors' experience, this technology can be used to improve outcomes for complicated spinal tumors wi…

Experience with surgical evacuation of neonatal brain abscess: A patient series and review of literature Open

Sunil Kumar, Pradeep Kumar, Vivek Sanker, Shean Aujla, Kanika Handu , et al. · 2025

Early diagnosis of neonatal brain abscess with high clinical suspicion use of neuroradiological imaging and prompt treatment with sensitive antibiotics and neurosurgical interventions can improve the prognosis and reduce its complications.

C-45 | Effectiveness of Posterior Pericardiotomy in Reducing Postoperative Atrial Fibrillation (POAF) Following Coronary Artery Bypass Grafting (CABG): A Systematic Review & Meta-Analysis of RCTs Open

Maneeth Mylavarapu, Muhammad Suleman Khan, Pankaj Kumar Singh, Ajay Verma, Muhammad Ibrahim , et al. · 2025

Use of Intraoperative Neurophysiological Monitoring (IONM) in a Neonate with Limited Dorsal Myeloschisis Open

Shyam Duvuru, Vivek Sanker, Yusra Arafeh, Rnad Alajarmeh · 2025

Limited dorsal myeloschisis (LDM) is a rare form of spinal dysraphism characterized by two constant features: a focal “closed” midline skin defect and a fibro-neural tract connecting the skin lesion to the underlying spinal cord. Excision …

A comprehensive analysis and systematic review of giant serpentine aneurysms Open

Oday Atallah, Zeinab Hammoud, Bahaa Aljeradat, Yasser F. Almealawy, Amr Badary , et al. · 2025

Introduction: Giant Serpentine Aneurysms (GSA) are a rare subgroup of complex intracranial vascular anomalies characterized by unusually large and convoluted structures within cerebral arteries. This systematic review examines the historic…

SGLT2 Inhibitors in COVID-19: Umbrella Review, Meta-Analysis, and Bayesian Sensitivity Assessment Open

Vinay Suresh, Muhammad Aaqib Shamim, Victor Ghosh, Tirth Dave, Malavika Jayan , et al. · 2025

Background: Several studies have reported a reduced risk of COVID-19-related mortality in patients taking antidiabetic medications. This is an umbrella review, meta-analysis, and Bayesian sensitivity assessment of SGLT2 inhibitors (SGLT2is…

Ancillary tests for brain death Open

Shyam Duvuru, Vivek Sanker, Rajeeb Kumar Mishra, Arvind Sharma, Shir Lynn Lim , et al. · 2025

Background Ancillary tests are often used in the determination of death by neurologic criteria (DNC), especially when the clinical examination is inconclusive. DNC is widely accepted, as defined by the comprehensive report of the World Bra…

Advances in chromosomal microarray analysis: Transforming neurology and neurosurgery Open

Wireko Andrew Awuah, Muhammad Hamza Shah, Vivek Sanker, Krishitha Meenu Mannan, Sruthi Ranganathan , et al. · 2025

322 - Role of Large Language Models in Urology: A systematic review and meta-analysis Open

M Raja Iyub, Mona Mittal, Abazr A. H. Ibrahim, Didier Samuel, atul sadana , et al. · 2025

Navigating the Thalamus: Role of Stereotactic Radiosurgery in the management of Brain Metastases - A Retrospective Study from a Single Institution Open

Jae‐Hyun Park, Rodas Asrat Kassu, Vivek Sanker, Amit Persad, Yusuke S. Hori , et al. · 2025

Intracranial ependymoma: A retrospective analysis of clinical features, treatment modalities, and long‐term outcome Open

Amr Badary, Sarah Zuhair Kurdi, Yasser F. Almealawy, Sura N. Alrubaye, Vivek Sanker , et al. · 2024

Objective Ependymomas, rare neuroglial tumors originating from ependymal cells, can occur in the CNS and typically affect the brain's ventricles or spinal cord. Prognosis is influenced by tumor grade, location, resection extent, and preope…

Sonic hedgehog signalling pathway in CNS tumours: its role and therapeutic implications Open

Wireko Andrew Awuah, Adam Ben-Jaafar, Jonathan Sing Huk Kong, Krishitha Meenu Mannan, Vivek Sanker , et al. · 2024

Genes to therapy: a comprehensive literature review of whole-exome sequencing in neurology and neurosurgery Open

Joecelyn Kirani Tan, Wireko Andrew Awuah, Arjun Ahluwalia, Vivek Sanker, Adam Ben-Jaafar , et al. · 2024

Nipah Virus Outbreaks in Kerala: An Impending Doom? Open

Vivek Sanker, Faheem Vellekkat, Tirth Dave · 2024

Background and Aims The resurgence of Nipah virus (NiV) in Kerala, India, represents a significant public health challenge. This paper aims to explore ongoing challenges associated with NiV transmission, focusing on environmental factors, …

Beyond the operating room: addressing the “second-victim” phenomenon in surgical practice Open

Wireko Andrew Awuah, Nicholas Aderinto, Arjun Ahluwalia, Jeisun Poornaselvan, Joecelyn Kirani Tan , et al. · 2024

Complications are plausible events during surgical operations. Surgical complications profoundly impact surgeons, often called "second victims" of adverse events. These complications trigger a range of emotional and psychological responses…

Foix–Alajouanine syndrome: a comprehensive overview of rare but relevant diagnosis Open

Oday Atallah, Yasser F. Almealawy, Roua Arian, Assma Dwebi, Amr Badary , et al. · 2024

Introduction: Foix–Alajouanine syndrome (FAS) is an uncommon neurological disorder marked by the gradual development of spinal cord congestion. First documented by Foix and Alajouanine in 1926. Although it is infrequent, delayed or misdiag…

Chiari malformation and its influence on trigeminal neuralgia: a systematic review Open

Amr Badary, Yasser F. Almealawy, William A. Florez-Perdomo, Vivek Sanker, Wireko Andrew Awuah , et al. · 2024

Objective: In order to properly understand the correlation between TN and Chiari malformation type I (CMI), it is imperative to delve into the underlying processes and develop efficacious treatment strategies. Methods: A comprehensive sear…

Chromosomal instability: a key driver in glioma pathogenesis and progression Open

Adele Mazzoleni, Wireko Andrew Awuah, Vivek Sanker, Hareesha Rishab Bharadwaj, Nicholas Aderinto , et al. · 2024

Immunotherapeutic advances in glioma management: The rise of vaccine‐based approaches Open

Wireko Andrew Awuah, Muhammad Hamza Shah, Joecelyn Kirani Tan, Sruthi Ranganathan, Vivek Sanker , et al. · 2024

Background Gliomas, particularly glioblastoma multiforme (GBM), are highly aggressive brain tumors that present significant challenges in oncology due to their rapid progression and resistance to conventional therapies. Despite advancement…

Navigating the clinical landscape of artery of Percheron infarction: A systematic review Open

Oday Atallah, Yasser F. Almealawy, Arwa Salam Alabide, Minaam Farooq, Vivek Sanker , et al. · 2024

miR-210 in ischaemic stroke: biomarker potential, challenges and future perspectives Open

Nicholas Aderinto, Gbolahan Olatunji, Emmanuel Kokori, Vivek Sanker, Ismaila Ajayi Yusuf , et al. · 2024

Ischaemic stroke, a leading cause of global morbidity and mortality, necessitates effective biomarkers for enhanced diagnostic and prognostic stratification. MicroRNAs (miRNAs), particularly miR-210, have emerged as promising candidates du…

Ventriculoperitoneal shunt extrusion in pediatric patients, clinical patterns and therapeutic strategies: A scoping review Open

Oday Atallah, Amr Badary, Fatma A. Monib, Yasser F. Almealawy, Aalaa Saleh , et al. · 2024

Background: Ventriculoperitoneal shunts (VPSs) are frequently employed in neurosurgery to treat hydrocephalus, with a particular focus on pediatric patients. Although VPSs are commonly utilized, they are not exempt from difficulties, such …

Intracerebral haemorrhage in multiple sclerosis: assessing the impact of disease-modifying medications Open

Brian M. Ou Yong, Wireko Andrew Awuah, Muhammad Hamza Shah, Vivek Sanker, Jonathan Kong Sing Huk , et al. · 2024

Multiple Sclerosis (MS) is a complex autoimmune disorder that significantly impacts the central nervous system, leading to a range of complications. While intracranial haemorrhage (ICH) is a rare but highly morbid complication, more common…

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