Vivian A. Paschoal
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View article: GPR84-mediated signal transduction affects metabolic function by promoting brown adipocyte activity
GPR84-mediated signal transduction affects metabolic function by promoting brown adipocyte activity Open
The G protein-coupled receptor 84 (GPR84), a medium-chain fatty acid receptor, has garnered attention because of its potential involvement in a range of metabolic conditions. However, the precise mechanisms underlying this effect remain el…
View article: Hepatic sialic acid synthesis modulates glucose homeostasis in both liver and skeletal muscle
Hepatic sialic acid synthesis modulates glucose homeostasis in both liver and skeletal muscle Open
These collective observations reveal that hepatic sialic acid synthesis and sialylation modulate glucose homeostasis in both the liver and skeletal muscle. By interrogating how hepatic sialic acid synthesis influences glucose control mecha…
View article: Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations Open
View article: GPR84-Mediated Signal Transduction Promotes Brown Adipocyte Function
GPR84-Mediated Signal Transduction Promotes Brown Adipocyte Function Open
SUMMARY G protein-coupled receptor 84 (GPR84), a medium-chain fatty acid receptor, may be involved in various metabolic conditions but the mechanism remains unclear. We found that GPR84 is highly expressed and functions in brown adipose ti…
View article: GPR92 activation in islet macrophages controls β cell function in a diet-induced obesity model
GPR92 activation in islet macrophages controls β cell function in a diet-induced obesity model Open
The molecular mechanisms underlying obesity-induced increases in β cell mass and the resulting β cell dysfunction need to be elucidated further. Our study revealed that GPR92, expressed in islet macrophages, is modulated by dietary interve…
View article: Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue
Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue Open
View article: Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity
Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity Open
View article: Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity
Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity Open
View article: Revisiting PPARγ as a new friend of GPR120 in the treatment of metabolic disorders
Revisiting PPARγ as a new friend of GPR120 in the treatment of metabolic disorders Open
G Protein-coupled receptor 120 (GPR120; fatty acid receptor 4, FFAR4) and PPARγ agonists both lead to anti-inflammatory and insulin sensitizing effects despite signalling through distinct pathways. We recently reported the overarching idea…
View article: SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1
SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1 Open
The synthesis of lipid and sterol species through de novo lipogenesis (DNL) is regulated by two functionally overlapping but distinct transcription factors: the sterol regulatory element-binding proteins (SREBPs) and carbohydrate response …
View article: Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis
Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis Open
View article: mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function
mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function Open
View article: One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance
One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance Open
Using mice rendered insulin resistant with high fat diets (HFD), we examined blood glucose levels and insulin resistance after i.v. delivery of an adeno-associated virus type 8 encoding murine urocortin 2 (AAV8.UCn2). A single i.v. injecti…
View article: Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice
Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice Open
View article: mTOR complexo 1 atenua a resposta pró-inflamatória de macrófagos e inflamação do tecido adiposo associadas à obesidade.
mTOR complexo 1 atenua a resposta pró-inflamatória de macrófagos e inflamação do tecido adiposo associadas à obesidade. Open
\n A inibição de mTOR com rapamicina exacerba a intolerância glicose associada a obesidade, um efeito que pode estar associado ao desenvolvimento de processo pró-inflamatório no tecido adiposo. O tratamento de camundongos com rapamicina ex…
View article: Omega‐3 fatty acids protect from diet‐induced obesity, glucose intolerance, and adipose tissue inflammation through PPARγ‐dependent and PPARγ‐independent actions
Omega‐3 fatty acids protect from diet‐induced obesity, glucose intolerance, and adipose tissue inflammation through PPARγ‐dependent and PPARγ‐independent actions Open
Scope We tested herein the hypothesis that peroxisome proliferator activated receptor γ (PPARγ) is a major mediator of omega‐3 ( n ‐3) protective actions against high‐fat diet (HFD) induced obesity, glucose intolerance, and adipose tissue …