Vivian Wing Chong Lau
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View article: Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models
Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models Open
Loss of IFNγ-sensitivity by tumours is thought to be a mechanism enabling evasion, but recent studies suggest that IFNγ-resistant tumours can be sensitised for immunotherapy, yet the underlying mechanism remains unclear. Here, we show that…
View article: IFNγ-dependent remodelling of the myeloid landscape underlies control of IFNγ-insensitive tumours
IFNγ-dependent remodelling of the myeloid landscape underlies control of IFNγ-insensitive tumours Open
Loss of IFNγ-sensitivity by tumours is thought to be a mechanism enabling evasion, as some cancers lacking IFNγ-signalling demonstrate resistance to checkpoint immunotherapy. However, recent studies demonstrated that IFNγ-resistant tumours…
View article: Bottoms up!: Inferring relevant immune phenotypes from bulk cytokine kinetics via semi-supervised machine learning
Bottoms up!: Inferring relevant immune phenotypes from bulk cytokine kinetics via semi-supervised machine learning Open
Immunologists frequently collect data on continuous multi-dimensional single-cell characteristics then classify cells based on these characteristics. Often, relevant cellular phenotypes (clusters) are determined by an iterative, intuition-…
View article: Supplementary Figures and Tables from Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells
Supplementary Figures and Tables from Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells Open
Supplementary Figures 1-8 and Tables 1-2
View article: Supplementary File S1 from Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells
Supplementary File S1 from Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells Open
Supplementary File S1
View article: Supplementary File S1 from Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells
Supplementary File S1 from Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells Open
Supplementary File S1
View article: Data from Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells
Data from Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells Open
Epitopes derived from mutated cancer proteins elicit strong antitumor T-cell responses that correlate with clinical efficacy in a proportion of patients. However, it remains unclear whether the subcellular localization of mutated proteins …
View article: Data from Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells
Data from Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells Open
Epitopes derived from mutated cancer proteins elicit strong antitumor T-cell responses that correlate with clinical efficacy in a proportion of patients. However, it remains unclear whether the subcellular localization of mutated proteins …
View article: Supplementary Figures and Tables from Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells
Supplementary Figures and Tables from Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells Open
Supplementary Figures 1-8 and Tables 1-2
View article: IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells
IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells Open
IFNγ is an immune mediator with concomitant pro- and anti-tumor functions. Here, we provide evidence that IFNγ directly acts on intra-tumoral CD8 T cells to restrict anti-tumor responses. We report that expression of the IFNγ receptor β ch…
View article: Manufacturing T cells in hollow fiber membrane bioreactors changes their programming and enhances their potency
Manufacturing T cells in hollow fiber membrane bioreactors changes their programming and enhances their potency Open
Engineered T cell therapies have revolutionized modern oncology, however processes for manufacturing T cell therapies vary and the impact of manufacturing processes On the cell product is poorly understood. Herein, we have used a commercia…
View article: 94 The T cell antigen coupler (TAC) redirects T cell oncolysis while limiting tonic signaling to create a safer engineered T cell product with a higher threshold for activation
94 The T cell antigen coupler (TAC) redirects T cell oncolysis while limiting tonic signaling to create a safer engineered T cell product with a higher threshold for activation Open
Background The T cell Antigen Couper (TAC) is a chimeric receptor that redirects the endogenous T cell receptor (TCR) against a tumor target via an extracellular antigen-binding domain to induce activation and oncolysis. TAC-engineered T c…
View article: A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity
A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity Open
Tumor-targeted chimeric antigen receptor (CAR)-engineered T lymphocytes (CAR-T cells) have demonstrated striking clinical success, but their use has been associated with a constellation of toxicities. A better understanding of the pathogen…
View article: Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells
Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells Open
Epitopes derived from mutated cancer proteins elicit strong antitumor T-cell responses that correlate with clinical efficacy in a proportion of patients. However, it remains unclear whether the subcellular localization of mutated proteins …
View article: The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity Open
View article: Characterizing the Response of TAC- and CAR-Engineered T cells Following Antigenic Stimulation
Characterizing the Response of TAC- and CAR-Engineered T cells Following Antigenic Stimulation Open
T lymphocytes engineered with chimeric antigen receptors (CARs) have shown remarkable
\nsuccess in the treatment of leukemias. Conventional CARs seek to recapitulate TCR and
\ncostimulatory signals through fusion of T cell signaling elem…
View article: Immunogenicity of Varicella Vaccine and Immunologic Predictors of Response in a Cohort of Elderly Nursing Home Residents
Immunogenicity of Varicella Vaccine and Immunologic Predictors of Response in a Cohort of Elderly Nursing Home Residents Open
NCT01328548.