Vivian Chua
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View article: Correction: Inhibition of NF-κB-Dependent Signaling Enhances Sensitivity and Overcomes Resistance to BET Inhibition in Uveal Melanoma
Correction: Inhibition of NF-κB-Dependent Signaling Enhances Sensitivity and Overcomes Resistance to BET Inhibition in Uveal Melanoma Open
View article: Elevated NR2F1 underlies the persistence of invasive disease after treatment of BRAF-mutant melanoma
Elevated NR2F1 underlies the persistence of invasive disease after treatment of BRAF-mutant melanoma Open
Despite the success of targeted inhibitors in cutaneous melanoma, therapeutic responses are limited by the aged tumor microenvironment and drug-tolerant residual cells. Given the similarities between drug tolerance and cellular dormancy, w…
View article: Figure S1 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma
Figure S1 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma Open
Figure S1. GSDMD cleavage fragments induced by Etomoxir.
View article: Data from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma
Data from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma Open
Few treatment options are available for patients with metastatic uveal melanoma. Although the bispecific tebentafusp is FDA approved, immunotherapy has largely failed, likely given the poorly immunogenic nature of uveal melanoma. Treatment…
View article: Figure S2 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma
Figure S2 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma Open
Figure S2. CPT1A ‘activity-signature’ score (GSVA) K-Means clustering and association with SCNA clusters in TCGA-UVM data.
View article: Table S1 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma
Table S1 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma Open
Table S1. PScore and CPT1A ‘activity’ signature gene sets.
View article: Table S2 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma
Table S2 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma Open
Table S2. UM patient ICb treatment groups in figure 7.
View article: Figure S3 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma
Figure S3 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma Open
Figure S3. Etomoxir-induced, pyroptotic DAMP release does not require GSDMD.
View article: Slow proliferation of BAP1-deficient uveal melanoma cells is associated with reduced S6 signaling and resistance to nutrient stress
Slow proliferation of BAP1-deficient uveal melanoma cells is associated with reduced S6 signaling and resistance to nutrient stress Open
Uveal melanoma (UM) is the deadliest form of eye cancer in adults. Inactivating mutations and/or loss of expression of the gene encoding BRCA1-associated protein 1 (BAP1) in UM tumors are associated with an increased risk of metastasis. To…
View article: Lineage commitment pathways epigenetically oppose oncogenic Gαq/11-YAP1 signaling in dormant disseminated uveal melanoma
Lineage commitment pathways epigenetically oppose oncogenic Gαq/11-YAP1 signaling in dormant disseminated uveal melanoma Open
Uveal melanoma (UM) can remain in clinical dormancy for decades only to later produce lethal metastases. Using Gαq/11 mut /BAP1 wt UM xenograft models and human metastatic samples, we identified NR2F1 as a key inducer of UM disseminated ca…
View article: Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma
Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma Open
View article: Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth
Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth Open
Uveal melanoma (UM) displays a high frequency of metastasis; however, effective therapies for metastatic UM are limited. Identifying unique metabolic features of UM may provide a potential targeting strategy. A lipid metabolism protein exp…
View article: Supplementary Data from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma
Supplementary Data from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma Open
Supplementary Data from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma
View article: Supplementary Figure from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma
Supplementary Figure from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma Open
Supplementary Figure from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma
View article: Data from Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma
Data from Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma Open
Patients with metastatic uveal melanoma usually die within 1 year of diagnosis, emphasizing an urgent need to develop new treatment strategies. The liver is the most common site of metastasis. Mitogen-activated protein kinase kinase (MEK) …
View article: Supplementary Table 1 from Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma
Supplementary Table 1 from Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma Open
Supplemental Table 1. RNA Seq z-score values for genes significantly up- or downregulated in MEKi-R or CDK4/6i-T groups compared to controls, corresponding to figure 3A. Data are indexed to show which genes are significant for each compari…
View article: Supplemental Figure 1-5 from Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma
Supplemental Figure 1-5 from Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma Open
Supplemental Figure 1: HGF inhibits trametinib-induced apoptosis in UM cells; Supplemental Figure 2: Bim-EL or Bmf expression renders UM cells susceptible to apoptosis; Supplemental Figure 3: Human hepatic stellate cell (HHSteC) conditione…
View article: Supplementary Figures 1-5 from Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma
Supplementary Figures 1-5 from Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma Open
Supplemental Figure 1. CDK4/6i + MEKi treatment does not modulate proteins within the apoptotic signaling pathway. Supplemental Figure 2. Growth of UM001 xenografts treated with MEKi and/or CDK4/6i. Supplemental Figure 3. RNA-seq samples c…
View article: Data from Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma
Data from Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma Open
Frequent GNAQ and GNA11 mutations in uveal melanoma hyperactivate the MEK–ERK signaling pathway, leading to aberrant regulation of cyclin-dependent kinases (CDK) and cell-cycle progression. MEK inhibitors (MEKi) alone show po…
View article: Supplemental Table 1 from Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma
Supplemental Table 1 from Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma Open
Supplemental Table 1: Patient characteristics and treatment history.
View article: Supplemental Table 1 from Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma
Supplemental Table 1 from Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma Open
Supplemental Table 1: Patient characteristics and treatment history.
View article: Supplemental Figure 1-5 from Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma
Supplemental Figure 1-5 from Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma Open
Supplemental Figure 1: HGF inhibits trametinib-induced apoptosis in UM cells; Supplemental Figure 2: Bim-EL or Bmf expression renders UM cells susceptible to apoptosis; Supplemental Figure 3: Human hepatic stellate cell (HHSteC) conditione…
View article: Data from Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma
Data from Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma Open
Frequent GNAQ and GNA11 mutations in uveal melanoma hyperactivate the MEK–ERK signaling pathway, leading to aberrant regulation of cyclin-dependent kinases (CDK) and cell-cycle progression. MEK inhibitors (MEKi) alone show po…
View article: Supplementary Data from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma
Supplementary Data from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma Open
Supplementary Data from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma
View article: Supplemental Figure Legends from Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma
Supplemental Figure Legends from Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma Open
Supplemental Figure 1 to 5 legends
View article: Supplementary Figure from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma
Supplementary Figure from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma Open
Supplementary Figure from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma
View article: Data from Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma
Data from Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma Open
Patients with metastatic uveal melanoma usually die within 1 year of diagnosis, emphasizing an urgent need to develop new treatment strategies. The liver is the most common site of metastasis. Mitogen-activated protein kinase kinase (MEK) …
View article: Data from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma
Data from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma Open
BRCA1-associated protein 1 (BAP1) is a tumor suppressor gene that is mutated in cancer, including uveal melanoma. Loss-of-function BAP1 mutations are associated with uveal melanoma metastasis and poor prognosis, but th…
View article: Supplementary Table 1 from Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma
Supplementary Table 1 from Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma Open
Supplemental Table 1. RNA Seq z-score values for genes significantly up- or downregulated in MEKi-R or CDK4/6i-T groups compared to controls, corresponding to figure 3A. Data are indexed to show which genes are significant for each compari…
View article: Supplementary Figures 1-5 from Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma
Supplementary Figures 1-5 from Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma Open
Supplemental Figure 1. CDK4/6i + MEKi treatment does not modulate proteins within the apoptotic signaling pathway. Supplemental Figure 2. Growth of UM001 xenografts treated with MEKi and/or CDK4/6i. Supplemental Figure 3. RNA-seq samples c…