Vivien A. C. Schoonenberg
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View article: Bidirectional control of a metabolic transition by the GID ubiquitin ligase
Bidirectional control of a metabolic transition by the GID ubiquitin ligase Open
Summary The GID/CTLH ubiquitin ligase is a multisubunit E3 conserved across eukaryotes. GID/CTLH has been implicated in a variety of processes, including metabolic regulation, cell proliferation, embryonic development and cell differentiat…
View article: <i>In cellulo</i> DNA assembly for targeted genomic integration and rearrangement in human cells
<i>In cellulo</i> DNA assembly for targeted genomic integration and rearrangement in human cells Open
Although therapeutic genome editing holds great potential to remedy diverse inherited and acquired disorders, targeted installation of medium to large sized genomic modifications in therapeutically relevant cells remains challenging. We ha…
View article: Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis
Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis Open
Mitochondrial tRNA taurine modifications mediated by mitochondrial tRNA translation optimization 1 ( Mto1 ) is essential for the mitochondrial protein translation. Mto1 deficiency was shown to induce proteostress in embryonic stem cells. A…
View article: AlexandrusPS: A User-Friendly Pipeline for the Automated Detection of Orthologous Gene Clusters and Subsequent Positive Selection Analysis
AlexandrusPS: A User-Friendly Pipeline for the Automated Detection of Orthologous Gene Clusters and Subsequent Positive Selection Analysis Open
The detection of adaptive selection in a system approach considering all protein-coding genes allows for the identification of mechanisms and pathways that enabled adaptation to different environments. Currently, available programs for the…
View article: Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis
Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis Open
A lack of the mitochondrial tRNA taurine modifications mediated by mitochondrial tRNA translation optimization 1 ( Mto1 ) was recently shown to induce proteostress in embryonic stem cells. Since erythroid precursors actively synthesize the…
View article: CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis
CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis Open
CRISPR/Cas9 pooled screening permits parallel evaluation of comprehensive guide RNA libraries to systematically perturb protein coding sequences in situ and correlate with functional readouts. For the analysis and visualization of the resu…
View article: CRISPRO Identifies Functional Protein Coding Sequences Based on Genome Editing Dense Mutagenesis
CRISPRO Identifies Functional Protein Coding Sequences Based on Genome Editing Dense Mutagenesis Open
CRISPR/Cas9 pooled screening permits parallel evaluation of comprehensive guide RNA libraries to systematically perturb protein coding sequences in situ and correlate with functional readouts. For the analysis and visualization of the resu…
View article: Additional file 2: of CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis
Additional file 2: of CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis Open
Table S1, Hit analysis RKO, DLD1 and NCI-H1299 cell lines (XLSX 74 kb)
View article: Additional file 3: of CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis
Additional file 3: of CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis Open
Table S2, Annotated CRISPRO output (XLSX 33034 kb)
View article: Aberrant hepatic lipid storage and metabolism in canine portosystemic shunts
Aberrant hepatic lipid storage and metabolism in canine portosystemic shunts Open
Non-alcoholic fatty liver disease (NAFLD) is a poorly understood multifactorial pandemic disorder. One of the hallmarks of NAFLD, hepatic steatosis, is a common feature in canine congenital portosystemic shunts. The aim of this study was t…