Vlad Alexandru Toma
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View article: Pilot Study Examining Mindfulness Intervention Effects on Perceived and Objective Stress in Adolescent Basketball Players
Pilot Study Examining Mindfulness Intervention Effects on Perceived and Objective Stress in Adolescent Basketball Players Open
Stress is a complex factor that significantly affects adolescent athletes, particularly in competitive environments such as basketball. This pilot study examined the effects of an intervention based on mindfulness, acceptance, and commitme…
View article: The Impact of Hybrid Bionanomaterials Based on Gold Nanoparticles on Liver Injury in an Experimental Model of Thioacetamide-Induced Hepatopathy
The Impact of Hybrid Bionanomaterials Based on Gold Nanoparticles on Liver Injury in an Experimental Model of Thioacetamide-Induced Hepatopathy Open
The present study aimed to evaluate the therapeutic benefits of a hybrid material based on gold nanoparticles and natural extracts on an experimental model of thioacetamide-induced (TAA) liver injury in rats. The nanomaterials were synthes…
View article: Molecular Effects of Cornelian Cherry Fruit (Cornus mas L.) Extract on Sleep Deprivation-Induced Oxidative Stress, Cytokine Dysregulation, and Behavioural Changes in Wistar Rats
Molecular Effects of Cornelian Cherry Fruit (Cornus mas L.) Extract on Sleep Deprivation-Induced Oxidative Stress, Cytokine Dysregulation, and Behavioural Changes in Wistar Rats Open
Sleep deprivation (SD) induces significant neurobiological changes, including oxidative stress, neuroinflammation, and behavioural impairments. This study was designed as a proof of concept to assess the potential for modulating the effect…
View article: Veterinary Perspectives on Hemoglobin-Based Oxygen Carriers in Experimental Hemorrhagic Shock: Insights from Rabbit Models
Veterinary Perspectives on Hemoglobin-Based Oxygen Carriers in Experimental Hemorrhagic Shock: Insights from Rabbit Models Open
Hemoglobin-based oxygen carriers (HBOCs) represent a promising alternative to traditional blood transfusions, offering the advantages of extended shelf life and avoiding blood compatibility limitations and infection risks. Positive effects…
View article: Effects of a Rosmarinus officinalis L. Extract and Rosmarinic Acid in Improving Streptozotocin-Induced Aortic Tissue Damages in Rats
Effects of a Rosmarinus officinalis L. Extract and Rosmarinic Acid in Improving Streptozotocin-Induced Aortic Tissue Damages in Rats Open
Background/Aim: Rosmarinus officinalis L. (R. officinalis) is an aromatic medicinal species with important nutraceutical potential, having rosmarinic acid (RA) as one of its main metabolites. The present study aims to evaluate the effects …
View article: A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular Diseases
A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular Diseases Open
Curcumin is among the most well-studied natural substances, known for its biological actions within the central nervous system, its antioxidant and anti-inflammatory properties, and human health benefits. However, challenges persist in eff…
View article: The Influence of Juglans regia L. Extract and Ellagic Acid on Oxidative Stress, Inflammation, and Bone Regeneration Biomarkers
The Influence of Juglans regia L. Extract and Ellagic Acid on Oxidative Stress, Inflammation, and Bone Regeneration Biomarkers Open
Bone regeneration is a highly dynamic and complex process that involves hematopoietic stem cells and mesenchymal cells, collagen fibers, non-collagenous proteins and biomolecules from extracellular matrices, and different cytokines and imm…
View article: The impact of vitamin D3 administration and of high fat diet on oxidative stress and inflammation in experimentally induced polycystic ovary syndrome
The impact of vitamin D3 administration and of high fat diet on oxidative stress and inflammation in experimentally induced polycystic ovary syndrome Open
Background. Polycystic ovary syndrome (PCOS) is commonly associated with obesity and may be exacerbated by the lack of vitamin D3. Aim. The study aimed to investigate the effects of vitamin D3 administration in female rats with PCOS and pr…
View article: Neurotrophic effects of iridoid glycosides from Lamium Album l. as natural GLP1-r modulators in repeated restraint stress
Neurotrophic effects of iridoid glycosides from Lamium Album l. as natural GLP1-r modulators in repeated restraint stress Open
The pleiotropic effects of Lamium species are extensively utilized for treating urinary bladder injuries and infections and addressing blood hypertension or liver toxicities. Despite widespread Lamium consumption in animals and humans, its…
View article: Chemical Composition and Antioxidant Activity of Six Allium Extracts Using Protein-Based Biomimetic Methods
Chemical Composition and Antioxidant Activity of Six Allium Extracts Using Protein-Based Biomimetic Methods Open
Medicinal plants are a valuable reservoir of novel pharmacologically active compounds. ROS and free radicals are primary contributors to oxidative stress, a condition associated with the onset of degenerative diseases such as cancer, coron…
View article: Evaluating Hepatic Toxicity of Chitosan and Chitosan- Functionalized Iron Oxide Nanoparticles in a Rat Model of Peripheral Nerve Injury — Relevance for Rehabilitation Medicine
Evaluating Hepatic Toxicity of Chitosan and Chitosan- Functionalized Iron Oxide Nanoparticles in a Rat Model of Peripheral Nerve Injury — Relevance for Rehabilitation Medicine Open
Background: Peripheral nerve injuries (PNI) can generate important medium- and long-term disability, as patients mostly complain about associated pain, sensibility and, or motor deficit, and even psychological manifestations. Chitosan and …
View article: Investigation of Epilobium hirsutum L. Optimized Extract’s Anti-Inflammatory and Antitumor Potential
Investigation of Epilobium hirsutum L. Optimized Extract’s Anti-Inflammatory and Antitumor Potential Open
Epilobium hirsutum L., commonly known as hairy willowherb, is a perennial herbaceous plant native to Europe and Asia. In Romania, the Epilobium genus includes 17 species that are used in folk medicine for various purposes. This study aimed…
View article: Betula pendula Leaf Extract Targets the Interplay between Brain Oxidative Stress, Inflammation, and NFkB Pathways in Amyloid Aβ1-42-Treated Rats
Betula pendula Leaf Extract Targets the Interplay between Brain Oxidative Stress, Inflammation, and NFkB Pathways in Amyloid Aβ1-42-Treated Rats Open
Alzheimer’s disease (AD) is known as the primary and most common cause of dementia in the middle-aged and elderly population worldwide. Chemical analyses of B. pendula leaf extract (BPE), performed using spectrophotometric and chromatograp…
View article: Discovery of New Hydrazone-Thiazole Polyphenolic Antioxidants through Computer-Aided Design and In Vitro Experimental Validation
Discovery of New Hydrazone-Thiazole Polyphenolic Antioxidants through Computer-Aided Design and In Vitro Experimental Validation Open
Oxidative stress is linked to a series of diseases; therefore, the development of efficient antioxidants might be beneficial in preventing or ameliorating these conditions. Based on the structure of a previously reported compound with good…
View article: The impact of chronic TMAO administration on liver oxidative stress, inflammation, and fibrosis
The impact of chronic TMAO administration on liver oxidative stress, inflammation, and fibrosis Open
Purpose TMAO, a gut microbiota derived byproduct, has been associated with various cardiometabolic diseases by promoting oxidative stress and inflammation. The liver is the main organ for TMAO production and chronic exposure to high doses …
View article: A Review on Integrated ZnO-Based SERS Biosensors and Their Potential in Detecting Biomarkers of Neurodegenerative Diseases
A Review on Integrated ZnO-Based SERS Biosensors and Their Potential in Detecting Biomarkers of Neurodegenerative Diseases Open
Surface-enhanced Raman spectroscopy (SERS) applications in clinical diagnosis and spectral pathology are increasing due to the potential of the technique to bio-barcode incipient and differential diseases via real-time monitoring of biomar…
View article: Chemoprotective Effect of Plantago sempervirens Crantz Extract on Ovarian Structure and Folliculogenesis
Chemoprotective Effect of Plantago sempervirens Crantz Extract on Ovarian Structure and Folliculogenesis Open
Alkylating agents such as cyclophosphamide (CPA) are commonly used in cytotoxic or immunosuppressive therapies for different types of diseases. One of the main secondary effects of such therapy is the reduction in follicular reserve, targe…
View article: THE PHYSIOLOGICAL EFFECTS PLAYING BEACH HANDBALL HAS ON JUNIOR HANDBALL INDOOR PLAYERS
THE PHYSIOLOGICAL EFFECTS PLAYING BEACH HANDBALL HAS ON JUNIOR HANDBALL INDOOR PLAYERS Open
Beach handball is a branch of sports that was born on the beaches of Italy in the early 1990s and it was designed to help players under go their physical training in a more dynamic training during the summer. Objectives. The main goal of t…
View article: Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin
Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin Open
Curcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data and clini…
View article: The Effect of Repeated Restraint Stress on Neuroglobin-Oligodendrocytes Functions in the CA3 Hippocampal Area and Their Involvements in the Signaling Pathways of the Stress-Induced Anxiety
The Effect of Repeated Restraint Stress on Neuroglobin-Oligodendrocytes Functions in the CA3 Hippocampal Area and Their Involvements in the Signaling Pathways of the Stress-Induced Anxiety Open
The present work shows the biochemical and structural fundamentals for the stress induced anxiety and stress adjustment response of the CA3 hippocampus area. Adult male Wistar rats were repeatedly exposed to a 3 h day restraint stress, for…
View article: The comparative effects of Resveratrol and Curcumin in combination with photodynamic therapy
The comparative effects of Resveratrol and Curcumin in combination with photodynamic therapy Open
Background and aim. Photodynamic therapy, PDT, is a promising option among the local treatments with oncolytic potential. Although the basic principle is simple, its intricate mechanisms allow for a broad range of optimization methods. The…
View article: Active Tumor-Targeting Nano-formulations Containing Simvastatin and Doxorubicin Inhibit Melanoma Growth and Angiogenesis
Active Tumor-Targeting Nano-formulations Containing Simvastatin and Doxorubicin Inhibit Melanoma Growth and Angiogenesis Open
Primary melanoma aggressiveness is determined by rapid selection and growth of cellular clones resistant to conventional treatments, resulting in metastasis and recurrence. In addition, a reprogrammed tumor-immune microenvironment supports…
View article: Glutaraldehyde‐Polymerized Hemerythrin: Evaluation of Performance as an Oxygen Carrier in Hemorrhage Models
Glutaraldehyde‐Polymerized Hemerythrin: Evaluation of Performance as an Oxygen Carrier in Hemorrhage Models Open
Hemoglobin‐based oxygen carriers (HBOCs) have been proposed and tested for several decades for the treatment of hemorrhage. We have previously proposed replacing hemoglobin (Hb) in HBOC with the oxygen‐carrying protein hemerythrin (Hr), fr…
View article: Co-Enhancing of Neuroglobin-Oligodendrocytes Function is a Stress Response Tuner for the CA3 Hippocampal Area with Involvements in Ethiology of Stress-Induced Anxiety
Co-Enhancing of Neuroglobin-Oligodendrocytes Function is a Stress Response Tuner for the CA3 Hippocampal Area with Involvements in Ethiology of Stress-Induced Anxiety Open
View article: Neurobehavioral and Ultrastructural Changes Induced by Phytosynthesized Silver-Nanoparticle Toxicity in an In Vivo Rat Model
Neurobehavioral and Ultrastructural Changes Induced by Phytosynthesized Silver-Nanoparticle Toxicity in an In Vivo Rat Model Open
(1) Background: The study aimed to assess neurobehavioral, ultrastructural, and biochemical changes induced by silver nanoparticles synthesized with Cornus mas L. extract (AgNPs-CM) in rat brains. (2) Methods: The study included 36 male ad…
View article: Remodeling tumor microenvironment by liposomal codelivery of DMXAA and simvastatin inhibits malignant melanoma progression
Remodeling tumor microenvironment by liposomal codelivery of DMXAA and simvastatin inhibits malignant melanoma progression Open
Anti-angiogenic therapies for melanoma have not yet been translated into meaningful clinical benefit for patients, due to the development of drug-induced resistance in cancer cells, mainly caused by hypoxia-inducible factor 1α (HIF-1α) ove…
View article: Phenolic Thiazoles with Antioxidant and Antiradical Activity. Synthesis, In Vitro Evaluation, Toxicity, Electrochemical Behavior, Quantum Studies and Antimicrobial Screening
Phenolic Thiazoles with Antioxidant and Antiradical Activity. Synthesis, In Vitro Evaluation, Toxicity, Electrochemical Behavior, Quantum Studies and Antimicrobial Screening Open
Oxidative stress represents the underlying cause of many chronic diseases in human; therefore, the development of potent antioxidant compounds for preventing or treating such conditions is useful. Starting from the good antioxidant and ant…
View article: THE COMPLEMENTARY ROLE OF THE RAMAN MICROSPECTROSCOPY TO THE OXIDATIVE STRESS ASSAYS IN THE NEONATAL SYNAPTOSOMES CHARACTERIZATION
THE COMPLEMENTARY ROLE OF THE RAMAN MICROSPECTROSCOPY TO THE OXIDATIVE STRESS ASSAYS IN THE NEONATAL SYNAPTOSOMES CHARACTERIZATION Open
Raman microspectroscopy was tested as an alternative/complementary method for biochemical evaluation of the synaptosomes obtained from neonatal rat brain prenatally exposed to sodium valproate and treated with allicin. Spectrophotometric a…
View article: Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress
Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress Open
In recent years, escitalopram (ESC) has been suggested to have different mechanisms of action beyond its well known selective serotonin reuptake inhibition. The aim of this study is to investigate the effects of escitalopram on oxidative s…
View article: Chitosan oral administration stimulates regeneration after experimentally induced peripheral nerve injury
Chitosan oral administration stimulates regeneration after experimentally induced peripheral nerve injury Open