Vladana Marković
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View article: Case report: Rapidly progressive neurocognitive disorder with a fatal outcome in a patient with PU.1 mutated agammaglobulinemia
Case report: Rapidly progressive neurocognitive disorder with a fatal outcome in a patient with PU.1 mutated agammaglobulinemia Open
Introduction PU.1-mutated agammaglobulinemia (PU.MA) represents a recently described autosomal-dominant form of agammaglobulinemia caused by mutation of the SPI1 gene. This gene codes for PU.1 pioneer transcription factor important for the…
View article: Gait Characteristics during Dual-Task Walking in Elderly Subjects of Different Ages
Gait Characteristics during Dual-Task Walking in Elderly Subjects of Different Ages Open
Background: In older age, walking ability gradually decreases due to factors including impaired balance, reduced muscle strength, and impaired vision and proprioception. Further, cognitive functions play a key role during walking and gradu…
View article: Wilson’s disease
Wilson’s disease Open
Wilson?s disease (WD) is an autosomal recessive inherited disorder of copper metabolism caused by mutations in the ATP7B gene, which is located on chromosome 13q14.3. The global genetic prevalence of WD at birth is approximately 13.9?15.4 …
View article: Patterns of neuropsychiatric symptoms in primary and secondary tauopathies: Caregiver and patient perspectives
Patterns of neuropsychiatric symptoms in primary and secondary tauopathies: Caregiver and patient perspectives Open
Introduction/Aims: Understanding the differences in neuropsychiatric symptoms (NPSs) across tauopathies, particularly in the early stages of the disease, may aid in differential diagnosis. The aims of the research are as follows: a) to exa…
View article: Examining the presence and frequency of impulse control disorders in Wilson's disease
Examining the presence and frequency of impulse control disorders in Wilson's disease Open
Introduction: Wilson's disease is a rare, hereditary disease, which leads to the accumulation of copper, primarily in the liver and brain, due to the impossibility of its excretion from the body. The disease is presented with hepatic, neur…
View article: Older age and Parkinson's disease
Older age and Parkinson's disease Open
The etiology of PD remains unclear, with aging identified as the primary risk factor. Epidemiological data show an increasing prevalence of PD with age, affecting 1 - 2% of persons over 65. The incidence of PD rises rapidly with age, peaki…
View article: Establishing an online resource to facilitate global collaboration and inclusion of underrepresented populations: Experience from the MJFF Global Genetic Parkinson’s Disease Project
Establishing an online resource to facilitate global collaboration and inclusion of underrepresented populations: Experience from the MJFF Global Genetic Parkinson’s Disease Project Open
Parkinson’s disease (PD) is the fastest-growing neurodegenerative disorder, currently affecting ~7 million people worldwide. PD is clinically and genetically heterogeneous, with at least 10% of all cases explained by a monogenic cause or s…
View article: Gait characteristics during dual task walking in elderly subjects of different age
Gait characteristics during dual task walking in elderly subjects of different age Open
Purpose: In older age walking ability gradually decreases due to factors including impaired balance, reduced muscle strength, and impaired vision and proprioception. Further, cognitive functions play a great role during walking and with ag…
View article: Altered Functional Connectivity of the Subthalamic Nucleus in Parkinson’s Disease: Focus on Candidates for Deep Brain Stimulation
Altered Functional Connectivity of the Subthalamic Nucleus in Parkinson’s Disease: Focus on Candidates for Deep Brain Stimulation Open
Background: The hypothesis that the effectiveness of deep brain stimulation (DBS) in Parkinson’s disease (PD) would be related to connectivity dysfunctions between the site of stimulation and other brain regions is growing. Objective: To i…
View article: MRI biomarkers of freezing of gait development in Parkinson’s disease
MRI biomarkers of freezing of gait development in Parkinson’s disease Open
This study investigated longitudinal clinical, structural and functional brain alterations in Parkinson’s disease patients with freezing of gait (PD-FoG) and in those developing (PD-FoG-converters) and not developing FoG (PD-non-converters…
View article: Phenotypic and Genetic Heterogeneity of Adult Patients with Hereditary Spastic Paraplegia from Serbia
Phenotypic and Genetic Heterogeneity of Adult Patients with Hereditary Spastic Paraplegia from Serbia Open
Hereditary spastic paraplegia (HSP) is among the most genetically diverse of all monogenic diseases. The aim was to analyze the genetic causes of HSP among adult Serbian patients. The study comprised 74 patients from 65 families clinically…
View article: Gait alterations in Parkinson’s disease at the stage of hemiparkinsonism—A longitudinal study
Gait alterations in Parkinson’s disease at the stage of hemiparkinsonism—A longitudinal study Open
Background Progressive gait impairment in Parkinson’s disease (PD) leads to significant disability. Quantitative gait parameters analysis provides valuable information about fine gait alterations. Objectives To analyse change of gait param…
View article: Longitudinal clinical, cognitive and neuroanatomical changes over five years in GBA‐positive Parkinson’s disease patients
Longitudinal clinical, cognitive and neuroanatomical changes over five years in GBA‐positive Parkinson’s disease patients Open
Background Glucocerebrosidase gene (GBA) mutations are the greatest genetic cause of Parkinson’s disease (PD). The aim of this study was to monitor the longitudinal disease course of PD patients with GBA mutation (GBA‐positive) at diagnosi…
View article: Changes of Phenotypic Pattern in Functional Movement Disorders: A Prospective Cohort Study
Changes of Phenotypic Pattern in Functional Movement Disorders: A Prospective Cohort Study Open
Introduction: Functional movement disorders (FMD) refer to a group of movement disorders that present with clinical characteristics incongruent to those due to established pathophysiologic processes, as for example in the case of neurodege…
View article: Risk factors for levodopa-induced dyskinesia in Parkinson’s disease patients
Risk factors for levodopa-induced dyskinesia in Parkinson’s disease patients Open
Background/Aim. Levodopa, the precursor of dopamine, is a substitute therapy for Parkinson''s disease. Long-term application of levodopa causes fluctuation in motor response and the occurrence of involuntary movements or dyskinesia. The ai…
View article: Psychiatric Symptoms in the Initial Motor Stage of Parkinson's Disease
Psychiatric Symptoms in the Initial Motor Stage of Parkinson's Disease Open
Neuropsychiatric symptoms (NPS) are common in Parkinson's disease (PD). The aim of this study was to estimate the correlates of NPS in patients with PD in the initial motor stage of the disease (hemiparkinsonism). A total of 111 patients w…
View article: Histopathological evaluation of response to neoadjuvant chemoradiotherapy in locally advanced rectal carcinoma
Histopathological evaluation of response to neoadjuvant chemoradiotherapy in locally advanced rectal carcinoma Open
Preoperative neoadjuvant chemoradiotherapy (nCRT) followed by radical surgical resection is the mainstay of curative therapy in the management of patients with locally advanced (stage II and III) rectal carcinoma in order to reduce local r…