Vladimir I. Vekshtein
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View article: Loss of the coronary microvascular response to acetylcholine in cardiac transplant patients.
Loss of the coronary microvascular response to acetylcholine in cardiac transplant patients. Open
BACKGROUND The coronary arteries of transplanted hearts frequently develop accelerated diffuse arteriosclerosis. The effects of this disease on resistance vessel function are unknown. METHODS AND RESULTS To investigate the integrity of end…
View article: Patients with evidence of coronary endothelial dysfunction as assessed by acetylcholine infusion demonstrate marked increase in sensitivity to constrictor effects of catecholamines.
Patients with evidence of coronary endothelial dysfunction as assessed by acetylcholine infusion demonstrate marked increase in sensitivity to constrictor effects of catecholamines. Open
BACKGROUND Studies in patients undergoing cardiac catheterization have demonstrated that normal coronary arteries dilate and atherosclerotic arteries constrict in response to exercise and the cold pressor test, but the mechanisms are unkno…
View article: The Effect of Atherosclerosis on the Vasomotor Response of Coronary Arteries to Mental Stress
The Effect of Atherosclerosis on the Vasomotor Response of Coronary Arteries to Mental Stress Open
Atherosclerosis disturbs the normal vasomotor response (no change or dilation) of large coronary arteries to mental stress; in patients with atherosclerosis paradoxical constriction occurs during mental stress, particularly at points of st…
View article: Coronary atherosclerosis is associated with left ventricular dysfunction and dilatation in aortic stenosis.
Coronary atherosclerosis is associated with left ventricular dysfunction and dilatation in aortic stenosis. Open
Patients with aortic stenosis develop widely variable patterns of left ventricular hypertrophy and dysfunction. We postulated that coronary atherosclerosis (CAD) may be associated with impaired left ventricular function and chamber dilatat…
View article: Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.
Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Open
In animals, acetylcholine dilates normal arteries and produces vasoconstriction in the presence of hypercholesterolemia, hypertension, or atherosclerosis, reflecting endothelial cell dysfunction. In patients with angiographically smooth co…