Vladimir Moiseyenko
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View article: Retrospective analysis of 5-year overall survival after trimodal therapy and radical cystectomy in real clinical practice
Retrospective analysis of 5-year overall survival after trimodal therapy and radical cystectomy in real clinical practice Open
bladder cancer, trimodal therapy, radical cystectomy, 5-year overall survival
View article: Drug therapy for respectable stomach cancer
Drug therapy for respectable stomach cancer Open
gastric cancer,neoadjuvant therapy,immunotherapy,targeted therapy
View article: Lenvatinib Plus Pembrolizumab, Pemetrexed, and a Platinum as First-Line Therapy for Metastatic Nonsquamous NSCLC: Phase 3 LEAP-006 Study
Lenvatinib Plus Pembrolizumab, Pemetrexed, and a Platinum as First-Line Therapy for Metastatic Nonsquamous NSCLC: Phase 3 LEAP-006 Study Open
ClinicalTrials.gov (https://clinicaltrials.gov/), NCT03829319.
View article: interventional radiology methods in the treatment of pancreatic cancer
interventional radiology methods in the treatment of pancreatic cancer Open
interventional radiology, pancreatic cancer, chemotherapy infusion, chemoembolization, energy ablation, cholangiodrainage, stenting, neurolysis.
View article: ANTITUmOR EFFECT IN VIVO AND THE IMPACT OF ALKALIZATION USING SODIUM BICARBONATE ON VIABILITY AND METABOLISM OF CT26 TUMOR CELLS
ANTITUmOR EFFECT IN VIVO AND THE IMPACT OF ALKALIZATION USING SODIUM BICARBONATE ON VIABILITY AND METABOLISM OF CT26 TUMOR CELLS Open
Tumor acidosis, Alkalizing therapy, Sodium bicarbonate, Cytotoxicity, Antiproliferative effect, Change in tumor cell metabolism.
View article: Phase 2 study of the antitumour activity and safety of simlukafusp alfa (FAP-IL2v) combined with atezolizumab in patients with recurrent and/or metastatic cervical squamous cell carcinoma
Phase 2 study of the antitumour activity and safety of simlukafusp alfa (FAP-IL2v) combined with atezolizumab in patients with recurrent and/or metastatic cervical squamous cell carcinoma Open
F. Hoffmann-La Roche Ltd.
View article: Neoadjuvant Immunotherapy Effectiveness in Patients With Microsatellite Instability-High (MSI-H) Gastric Cancer
Neoadjuvant Immunotherapy Effectiveness in Patients With Microsatellite Instability-High (MSI-H) Gastric Cancer Open
View article: Tumor alkalization therapy: misconception or good therapeutics perspective? – the case of malignant ascites
Tumor alkalization therapy: misconception or good therapeutics perspective? – the case of malignant ascites Open
Tumor acidity has been identified as a key factor in promoting cancer progression, metastasis, and resistance. Tumor alkalization therapy has emerged as a potential strategy for cancer treatment. This article provides preclinical and clini…
View article: BRCA-associated ovarian cancer in the russian patient population. Analysis of the non-interventional study Ovatar
BRCA-associated ovarian cancer in the russian patient population. Analysis of the non-interventional study Ovatar Open
Purpose : To evaluate the proportion of BRCA1 / 2 mutations in patients with serous and endometrioid cancer of the ovary, fallopian tube, and peritoneum in Russia, to evaluate the percentage of germinal and somatic mutations, to identify t…
View article: Modeling of absorption spectrum of 2,5-bis(2-benzoxazolyl)hydroquinone
Modeling of absorption spectrum of 2,5-bis(2-benzoxazolyl)hydroquinone Open
Vibronic structure of the absorption band of 2,5-bis(2-benzoxazolyl)hydroquinone is calculated for the transitions to the first excited state using the Franck-Condon approximation and harmonic model for vibrations. 2,5-bis(2-benzoxazolyl)h…
View article: 64O Lenvatinib plus pembrolizumab, pemetrexed, and a platinum (len + pembro + chemo) as first-line therapy for metastatic non squamous non-small cell lung cancer (NSCLC): Phase III LEAP-006 study
64O Lenvatinib plus pembrolizumab, pemetrexed, and a platinum (len + pembro + chemo) as first-line therapy for metastatic non squamous non-small cell lung cancer (NSCLC): Phase III LEAP-006 study Open
LEAP-006 is a 2-part phase 3 study of len + pembro + chemo as first-line therapy for metastatic nonsquamous NSCLC (NCT03829319). Part 1 established len 8 mg/d as the recommended starting dose when added to pembro + chemo. We present result…
View article: Generation of Singlet Oxygen by Laser Infrared Radiation 1273 nm and Evaluation of Cytotoxic Effect on Tumor Cell Lines
Generation of Singlet Oxygen by Laser Infrared Radiation 1273 nm and Evaluation of Cytotoxic Effect on Tumor Cell Lines Open
Increased reactivity makes singlet oxygen a cytotoxic agent. Infrared radiation at 1273 nm allows for direct photogeneration of singlet oxygen without the use of a photosensitizer. In this study, we demonstrated direct photogeneration of s…
View article: Thermal Effect of IR Radiation at 1273 nm during Direct Photogeneration of Singlet Oxygen for Solid Tumors Therapy
Thermal Effect of IR Radiation at 1273 nm during Direct Photogeneration of Singlet Oxygen for Solid Tumors Therapy Open
Singlet oxygen is an electronically excited state of normal triplet oxygen that has cytotoxic effects. The generation of singlet oxygen as a result of photodynamic therapy is used for the treatment of solid tumors. Methods of singlet oxyge…
View article: Six-Year Survival Outcomes for Patients with HER2-Positive Early Breast Cancer Treated with CT-P6 or Reference Trastuzumab: Observational Follow-Up Study of a Phase 3 Randomised Controlled Trial
Six-Year Survival Outcomes for Patients with HER2-Positive Early Breast Cancer Treated with CT-P6 or Reference Trastuzumab: Observational Follow-Up Study of a Phase 3 Randomised Controlled Trial Open
2019-003518-15 (retrospectively registered 10 March 2020).
View article: A phase 1b study of the allosteric extracellular FGFR2 inhibitor alofanib in patients with pretreated advanced gastric cancer
A phase 1b study of the allosteric extracellular FGFR2 inhibitor alofanib in patients with pretreated advanced gastric cancer Open
Purpose Alofanib is a small-molecule allosteric extracellular FGFR2 inhibitor. We report safety and preliminary efficacy from the first-in-human phase 1b study of alofanib in heavily pretreated patients with advanced gastric cancer. Method…
View article: Discrimination between Complete versus Non-Complete Pathologic Response to Neoadjuvant Therapy Using Ultrasensitive Mutation Analysis: A Proof-of-Concept Study in BRCA1-Driven Breast Cancer Patients
Discrimination between Complete versus Non-Complete Pathologic Response to Neoadjuvant Therapy Using Ultrasensitive Mutation Analysis: A Proof-of-Concept Study in BRCA1-Driven Breast Cancer Patients Open
Neoadjuvant chemotherapy (NACT) for breast cancer (BC) often results in pathologic complete response (pCR), i.e., the complete elimination of visible cancer cells. It is unclear whether the use of ultrasensitive genetic methods may still d…
View article: Influence of coordination environment and dielectric contrast on the spectral-luminescent properties of europium ions in the pores of film opals
Influence of coordination environment and dielectric contrast on the spectral-luminescent properties of europium ions in the pores of film opals Open
The photoluminescence spectra of the inorganic salt of europium C6H9EuO6 × H2O in the pores of film opals, with globule diameter D ≈ 300 nm on a glass substrate, were measured. In the measured spectra the radiative transitions in the energ…
View article: Fabrication and optical characteristics of opal photonic crystal films and heterostructures
Fabrication and optical characteristics of opal photonic crystal films and heterostructures Open
The relevance of fabrication and investigation of opals and opal-based structures is due to their ability to control the emission and propagation of light. Using the method of vertically moving meniscus we obtain both single opal films and…
View article: Computational study of electronic-vibrational spectrum of rotamers of 2-(2'-hydroxyphenyl)benzoxazole
Computational study of electronic-vibrational spectrum of rotamers of 2-(2'-hydroxyphenyl)benzoxazole Open
UV-vis absorption spectrum of internally hydrogen-bonded enol structures of 2-(2'-hydroxyphenyl)benzoxazole is calculated for the transitions to the first excited state using the Franck-Condon approximation and harmonic model for vibration…
View article: Calculations of molecular properties of 2-(2'-hydroxyphenyl)benzoxazole by semi-empirical tight-binding methods
Calculations of molecular properties of 2-(2'-hydroxyphenyl)benzoxazole by semi-empirical tight-binding methods Open
The semi-empirical tight-binding methods GFN1-xTB and GFN2-xTB are applied to calculations of structure, energy and normal vibrations of the molecule of 2-(2'-hydroxyphenyl)benzoxazole undergoing excited state intramolecular proton transfe…
View article: NEPTUNE: Phase 3 Study of First-Line Durvalumab Plus Tremelimumab in Patients With Metastatic NSCLC
NEPTUNE: Phase 3 Study of First-Line Durvalumab Plus Tremelimumab in Patients With Metastatic NSCLC Open
NEPTUNE did not meet its primary end point of improved OS with durvalumab plus tremelimumab versus chemotherapy in patients with mNSCLC and bTMB greater than or equal to 20 mut/Mb. Despite the amended study design, with a resultant small p…
View article: Tumor acidity: From hallmark of cancer to target of treatment
Tumor acidity: From hallmark of cancer to target of treatment Open
Tumor acidity is one of the cancer hallmarks and is associated with metabolic reprogramming and the use of glycolysis, which results in a high intracellular lactic acid concentration. Cancer cells avoid acid stress major by the activation …
View article: First-line trifluridine/tipiracil + bevacizumab in patients with unresectable metastatic colorectal cancer: final survival analysis in the TASCO1 study
First-line trifluridine/tipiracil + bevacizumab in patients with unresectable metastatic colorectal cancer: final survival analysis in the TASCO1 study Open
View article: Monitoring of the presence of EGFR-mutated DNA during EGFR-targeted therapy may assist in the prediction of treatment outcome
Monitoring of the presence of EGFR-mutated DNA during EGFR-targeted therapy may assist in the prediction of treatment outcome Open
View article: Antitumor efficacy of an isolated hind legperfusion with a pH-increased solution in thePliss’ lymphosarcoma graft rat model
Antitumor efficacy of an isolated hind legperfusion with a pH-increased solution in thePliss’ lymphosarcoma graft rat model Open
Background: The technique of regional isolated perfusion makes it possible to increase local levels of an anti-tumor agent, to perform the treatment procedure under hypothermia or hyperthermia, to reduce or even eliminate any systemic effe…
View article: Tumor irradiation may facilitate the detection of tumor-specific mutations in plasma
Tumor irradiation may facilitate the detection of tumor-specific mutations in plasma Open
Local tumor irradiation may facilitate the detection of tumor-specific DNA in the bloodstream. These data justify further assessment of the clinical feasibility of irradiation-assisted liquid biopsy.
View article: Increase in ionic conductivity in the nanocrystalline phase NaBi(MoO4)2:Gd3+
Increase in ionic conductivity in the nanocrystalline phase NaBi(MoO4)2:Gd3+ Open
Nanocomposite based on synthetic opal soaked with the NaBi(MO4)2:Gd3+ melt was characterized by X-ray diffraction patterns and Raman spectroscopy technique. Crystalline state of the substance inside opal pores was proved for the composite.…
View article: Computational modeling of schedule-specific chemotherapy outcomes in mouse tumor model
Computational modeling of schedule-specific chemotherapy outcomes in mouse tumor model Open
Despite the rapid development of new innovative strategies in cancer treatment like immunotherapy, chemotherapy still remains a common choice in many cases. Standard protocols of chemotherapeutic administration rely on a maximal tolerated …
View article: Fulvestrant-Palbociclib vs Letrozole-Palbociclib as Initial Therapy for Endocrine-Sensitive, Hormone Receptor–Positive, <i>ERBB2</i>-Negative Advanced Breast Cancer
Fulvestrant-Palbociclib vs Letrozole-Palbociclib as Initial Therapy for Endocrine-Sensitive, Hormone Receptor–Positive, <i>ERBB2</i>-Negative Advanced Breast Cancer Open
ClinicalTrials.gov Identifier: NCT02491983.
View article: PL02.05 IMpower010: Characterization of Stage IB-IIIA NSCLC Patients by Type and Extent of Therapy Prior to Adjuvant Atezolizumab
PL02.05 IMpower010: Characterization of Stage IB-IIIA NSCLC Patients by Type and Extent of Therapy Prior to Adjuvant Atezolizumab Open