Vladimír Študent
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View article: Case report: Radical robotic nephroureterectomy after chemotherapy followed by avelumab in a patient with node-positive UTUC
Case report: Radical robotic nephroureterectomy after chemotherapy followed by avelumab in a patient with node-positive UTUC Open
Introduction Platinum-based chemotherapy followed by the immune checkpoint inhibitor avelumab represents an intensified upfront therapy regimen that may result in significant downstaging and, subsequently, potentially radical robotic nephr…
View article: Frequency of benign tumors after partial nephrectomy and the association between malignant tumor findings and preoperative clinical parameters
Frequency of benign tumors after partial nephrectomy and the association between malignant tumor findings and preoperative clinical parameters Open
Background Partial nephrectomy (PN) has become the dominant treatment modality for cT1 renal tumor lesions. Tumors suspected of malignant potential are indicated for surgery, but some are histologically classified as benign lesions after s…
View article: Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells
Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells Open
View article: Reply to Child, R. Comment on “Cesak et al. Carnosine and Beta-Alanine Supplementation in Human Medicine: Narrative Review and Critical Assessment. Nutrients 2023, 15, 1770”
Reply to Child, R. Comment on “Cesak et al. Carnosine and Beta-Alanine Supplementation in Human Medicine: Narrative Review and Critical Assessment. Nutrients 2023, 15, 1770” Open
Thank you very much for your comment [...]
View article: The Evolving Landscape of Cytoreductive Nephrectomy in Metastatic Renal Cell Carcinoma
The Evolving Landscape of Cytoreductive Nephrectomy in Metastatic Renal Cell Carcinoma Open
The role of cytoreductive nephrectomy in metastatic renal cell carcinoma (RCC) has been studied intensively over the past few decades. Interestingly, the opinion with regard to the importance of this procedure has switched from a recommend…
View article: Neoadjuvant nivolumab and cabozantinib in advanced renal cell carcinoma in a horseshoe kidney – how to achieve a safe and radical resection? a case report and review of the literature
Neoadjuvant nivolumab and cabozantinib in advanced renal cell carcinoma in a horseshoe kidney – how to achieve a safe and radical resection? a case report and review of the literature Open
Introduction Neoadjuvant nivolumab and cabozantinib in locally advanced renal cell carcinoma in a horseshoe kidney is a novel therapeutic approach in the preoperative setting. Methods We report a case of a 52-year old male who presented wi…
View article: Frequency of benign tumors after partial nephrectomy and the association between malignant tumor findings and preoperative clinical parameters
Frequency of benign tumors after partial nephrectomy and the association between malignant tumor findings and preoperative clinical parameters Open
Background Partial nephrctomy (PN) has become the dominant treatment modality for cT1 renal tumor lesions. Tumors suspected of malignant potential are indicated for surgery, but some are histologically classified as benign lesions after su…
View article: Carnosine and Beta-Alanine Supplementation in Human Medicine: Narrative Review and Critical Assessment
Carnosine and Beta-Alanine Supplementation in Human Medicine: Narrative Review and Critical Assessment Open
The dipeptide carnosine is a physiologically important molecule in the human body, commonly found in skeletal muscle and brain tissue. Beta-alanine is a limiting precursor of carnosine and is among the most used sports supplements for impr…
View article: Niraparib and Abiraterone Acetate for Metastatic Castration-Resistant Prostate Cancer
Niraparib and Abiraterone Acetate for Metastatic Castration-Resistant Prostate Cancer Open
PURPOSE Metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease with current standard-of-care therapies. Homologous recombination repair (HRR) gene alterations, including BRCA1/2 alterations, can sensitize cancer c…
View article: A-ring-fused pyrazoles of dihydrotestosterone targeting prostate cancer cells via the downregulation of the androgen receptor
A-ring-fused pyrazoles of dihydrotestosterone targeting prostate cancer cells via the downregulation of the androgen receptor Open
View article: A-ring-fused pyrazoles of dihydrotestosterone targeting prostate cancer cells via the downregulation of the androgen receptor
A-ring-fused pyrazoles of dihydrotestosterone targeting prostate cancer cells via the downregulation of the androgen receptor Open
High expression of the androgen receptor (AR) and the disruption of its regulation are strongly responsible for the development of prostate cancer (PCa). Therapeutically relevant non-steroidal or steroidal antiandrogens are able to block t…
View article: Advantages and limitations of 3D organoids and ex vivo tumor tissue culture in personalized medicine for prostate cancer
Advantages and limitations of 3D organoids and ex vivo tumor tissue culture in personalized medicine for prostate cancer Open
We have established cultures of both organoids and tissue fragments from PCa patient samples. However, the expression of tumor markers was not recapitulated in organoids. Inconsistent morphology among tissue fragments and low proliferation…
View article: Altered Plasma, Urine, and Tissue Profiles of Sulfatides and Sphingomyelins in Patients with Renal Cell Carcinoma
Altered Plasma, Urine, and Tissue Profiles of Sulfatides and Sphingomyelins in Patients with Renal Cell Carcinoma Open
Purpose: RCC, the most common type of kidney cancer, is associated with high mortality. A non-invasive diagnostic test remains unavailable due to the lack of RCC-specific biomarkers in body fluids. We have previously described a significan…
View article: The Role of Cytoreductive Nephrectomy in Renal Cell Carcinoma with Sarcomatoid Histology: A Case Series and Review of the Literature
The Role of Cytoreductive Nephrectomy in Renal Cell Carcinoma with Sarcomatoid Histology: A Case Series and Review of the Literature Open
Background: Renal cell carcinoma with sarcomatoid dedifferentiation represents a rare histological entity characterized by aggressive behavior, limited efficacy of tyrosine kinase inhibitors or mTOR inhibitors, and poor outcome. The immune…
View article: Toll-Like Receptor 3 Overexpression Induces Invasion of Prostate Cancer Cells, whereas Its Activation Triggers Apoptosis
Toll-Like Receptor 3 Overexpression Induces Invasion of Prostate Cancer Cells, whereas Its Activation Triggers Apoptosis Open
View article: A Pathological Complete Response to the Combination of Ipilimumab and Nivolumab in a Patient with Metastatic Renal Cell Carcinoma
A Pathological Complete Response to the Combination of Ipilimumab and Nivolumab in a Patient with Metastatic Renal Cell Carcinoma Open
Background and Objectives: Complete pathological response after ipilimumab and nivolumab combination therapy in a patient with intermediate prognosis renal cell carcinoma is an uncommon finding. Case presentation: A 60-year-old man present…
View article: The use of biomarkers in the diagnosis and treatment of obstruction of the upper urinary tract in children
The use of biomarkers in the diagnosis and treatment of obstruction of the upper urinary tract in children Open
Antenatal hydronephrosis, dilatation of the upper urinary tract (UUTD), is a common finding on prenatal ultrasound. One of the most common causes is ureteropelvic junction (UPJ) obstruction. Although such prenatally diagnosed UUTD resolves…
View article: Altered plasma, urine, and tissue profiles of sulfatides and sphingomyelins in patients with renal cell carcinoma
Altered plasma, urine, and tissue profiles of sulfatides and sphingomyelins in patients with renal cell carcinoma Open
Renal cell carcinoma (RCC) represents the most common type of kidney cancer and, despite the progress of surgical and medical management, is associated with high mortality. In this study, we demonstrate that RCC-related processes change bo…
View article: Peritoneal flap fixation: effect on the prevention of lymphocele formation after radical prostatectomy with lymphadenectomy
Peritoneal flap fixation: effect on the prevention of lymphocele formation after radical prostatectomy with lymphadenectomy Open
FN Olomouc a LF UP Olomouc 3 Onkologická klinika FN Olomouc a LF UP Olomouc Radikální prostatektomie (RP) s rozšířenou pánevní lymfadenektomií (ePLND) představuje standardní terapii středně a vysoce rizikového lokalizovaného karcinomu pros…
View article: Diagnosis and staging of renal cell carcinoma
Diagnosis and staging of renal cell carcinoma Open
Karcinom ledviny představuje 2-3 % ze všech maligních onemocnění člověka.Jeho incidence v České republice trvale stoupá a je nejvyšší na celém světě.Vzhledem k vývoji a rutinnímu využívání zobrazovacích metod je v současné době většina nád…
View article: 864 Minimally invasive versus open hysterectomy in high-risk endometrial cancer: a propensity score matching analysis
864 Minimally invasive versus open hysterectomy in high-risk endometrial cancer: a propensity score matching analysis Open
Introduction/Background* Randomized trials have shown comparable oncologic outcomes between open versus minimally invasive surgery for endometrial cancer. Limited data is available specifically in patients with high-risk disease. The aim o…
View article: Progression of prostate cancer after radical prostatectomy despite undetectable PSA levels
Progression of prostate cancer after radical prostatectomy despite undetectable PSA levels Open
Karcinom prostaty je v současné době třetím nejčastějším onkologickým onemocněním u mužů v ČR a druhým nejčastěji se vyskytujícím nádorem u mužů v celosvětovém měřítku.Jeho incidence každým rokem stoupá.Každým rokem jsou aktualizovány diag…
View article: Pre-existing cell subpopulations in primary prostate cancers display surface fingerprint of docetaxel-resistant cells
Pre-existing cell subpopulations in primary prostate cancers display surface fingerprint of docetaxel-resistant cells Open
Background Docetaxel resistance represents a leading obstacle in the therapy of prostate cancer (PCa), resulting in lethal disease. Intratumoral heterogeneity, which is frequently driven by epithelial-mesenchymal plasticity significantly c…
View article: Correction to: Is health‑related quality of life of patients after single‑use flexible ureteroscopy superior to extracorporeal shock wave lithotripsy? A randomised prospective study
Correction to: Is health‑related quality of life of patients after single‑use flexible ureteroscopy superior to extracorporeal shock wave lithotripsy? A randomised prospective study Open
View article: Carnosine and β-alanine in aging. Their impact on skeletal muscle and neurodegenerative disorders
Carnosine and β-alanine in aging. Their impact on skeletal muscle and neurodegenerative disorders Open
LF UP a Fakultní nemocnice Olomouc 2 Ústav lékařské chemie a biochemie LF
View article: Do not underestimate anterior prostate cancer
Do not underestimate anterior prostate cancer Open
The frequency of anterior tumours is higher than previously thought, and they include tumours requiring radical treatment. When these tumours are neglected, it may lead to patient undertreatment with impact on their life prognosis. Thus, w…
View article: 26 Meta-analysis comparing influence of no adjuvant treatment, postoperative radiotherapy and/or chemotherapy on survival in patients after primary surgery including lymphadenectomy for early stage uterine carcinosarcoma
26 Meta-analysis comparing influence of no adjuvant treatment, postoperative radiotherapy and/or chemotherapy on survival in patients after primary surgery including lymphadenectomy for early stage uterine carcinosarcoma Open
Introduction Uterine carcinosarcoma (UCS, malignant mixed Müllerian tumor) is rare but aggressive form of endometrial cancer according to metastatic potential. Standard treatment is primary surgery. Adjuvant therapy improves survival in ad…
View article: A phase 3, open-label, multicenter study of a 6-month pre-mixed depot formulation of leuprolide mesylate in advanced prostate cancer patients
A phase 3, open-label, multicenter study of a 6-month pre-mixed depot formulation of leuprolide mesylate in advanced prostate cancer patients Open
View article: Generation of human iPSCs from human prostate cancer-associated fibroblasts IBPi002-A
Generation of human iPSCs from human prostate cancer-associated fibroblasts IBPi002-A Open
A human induced pluripotent stem cell line was generated from cancer-associated fibroblasts of a 68-years old patient with diagnosed prostate adenocarcinoma (PCa). The fibroblast cell line was reprogrammed with Epi5™ Episomal iPSC Reprogra…
View article: Renal cell carcinoma with tumor thrombus extending in the right atrium
Renal cell carcinoma with tumor thrombus extending in the right atrium Open
Karcinom ledviny je nejčastějším primárním nádorem ledviny a Česká republika má z celého světa jeho nejvyšší incidenci.V do bě diagnózy je u 4-10 % pacientů zaznamenán nádorový trombus prorůstající do dolní duté žíly.Přesto je karcinom led…