Vladimir Zanki
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View article: Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif
Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif Open
Antibiotics target key biological processes that include protein synthesis. Bacteria respond by developing resistance, which increases rapidly due to antibiotics overuse. Mupirocin, a clinically used natural antibiotic, inhibits isoleucyl-…
View article: Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif
Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif Open
Antibiotics target key biological processes that include protein synthesis. Bacteria respond by developing resistance, which increases rapidly due to antibiotics overuse. Mupirocin, a clinically used natural antibiotic, inhibits isoleucyl-…
View article: A pair of isoleucyl-tRNA synthetases in Bacilli fulfill complementary roles to keep fast translation and provide antibiotic resistance
A pair of isoleucyl-tRNA synthetases in Bacilli fulfill complementary roles to keep fast translation and provide antibiotic resistance Open
Isoleucyl-tRNA synthetase (IleRS) is an essential enzyme that covalently couples isoleucine to the corresponding tRNA. Bacterial IleRSs group in two clades, ileS1 and ileS2, the latter bringing resistance to the natural antibiotic mupiroci…