Vlasta Lungová
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View article: Toll Like Receptors in the Larynx: Implications for Laryngeal Immunology
Toll Like Receptors in the Larynx: Implications for Laryngeal Immunology Open
Rationale Although optimal epithelial barrier function is essential to laryngeal health and disease, there is a surprising paucity of literature on the underlying immunological mechanisms in laryngeal epithelia. Toll like receptors (TLR) a…
View article: Contribution of <i>Streptococcus pseudopneumoniae</i> and <i>Streptococcus salivarius</i> to vocal fold mucosal integrity and function
Contribution of <i>Streptococcus pseudopneumoniae</i> and <i>Streptococcus salivarius</i> to vocal fold mucosal integrity and function Open
Structural changes to the vocal fold (VF) epithelium, namely, loosened intercellular junctions, have been reported in VF benign lesions. The potential mechanisms responsible for the disruption of cell junctions do not address the contribut…
View article: Piezo1-expressing vocal fold epithelia modulate remodeling via effects on self-renewal and cytokeratin differentiation
Piezo1-expressing vocal fold epithelia modulate remodeling via effects on self-renewal and cytokeratin differentiation Open
View article: Transcriptome Dynamics in the Developing Larynx, Trachea, and Esophagus
Transcriptome Dynamics in the Developing Larynx, Trachea, and Esophagus Open
The larynx, trachea, and esophagus share origin and proximity during embryonic development. Clinical and experimental evidence support the existence of neurophysiological, structural, and functional interdependencies before birth. This inv…
View article: Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling
Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling Open
Vaping has been reported to cause acute epiglottitis, a life-threatening airway obstruction induced by direct epithelial injury and subsequent inflammatory reaction. Here, we show that we were able to recapitulate this phenomenon in vitro.…
View article: Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis
Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis Open
View article: Characterization of intrauterine growth, proliferation and biomechanical properties of the murine larynx
Characterization of intrauterine growth, proliferation and biomechanical properties of the murine larynx Open
Current research approaches employ traditional tissue engineering strategies to promote vocal fold (VF) tissue regeneration, whereas recent novel advances seek to use principles of developmental biology to guide tissue generation by mimick…
View article: Novel immortalized human vocal fold epithelial cell line: In vitro tool for mucosal biology
Novel immortalized human vocal fold epithelial cell line: In vitro tool for mucosal biology Open
Study of vocal fold (VF) mucosal biology requires essential human vocal fold epithelial cell (hVFE) lines for use in appropriate model systems. We steadily transfected a retroviral construct containing human telomerase reverse transcriptas…
View article: Derivation of Three-Dimensional Human Induced Pluripotent Stem Cell-Derived Vocal Fold Mucosa for Clinical and Pharmacological Applications
Derivation of Three-Dimensional Human Induced Pluripotent Stem Cell-Derived Vocal Fold Mucosa for Clinical and Pharmacological Applications Open
View article: Characterization of intrauterine growth, proliferation and biomechanical properties of the murine larynx
Characterization of intrauterine growth, proliferation and biomechanical properties of the murine larynx Open
Raw data for all variables in study
View article: Characterization of intrauterine growth, proliferation and biomechanical properties of the murine larynx
Characterization of intrauterine growth, proliferation and biomechanical properties of the murine larynx Open
Raw data for all variables in study
View article: Electronic cigarette vaping triggers lipid mediated vocal fold mucosal injury
Electronic cigarette vaping triggers lipid mediated vocal fold mucosal injury Open
Electronic cigarettes (e-cigs) are nicotine delivery systems that have been touted as safer alternatives to smoking. A recently reported case of epiglottitis revealed a connection between vaping and swollen laryngeal and vocal fold (VF) st…
View article: Drainage of amniotic fluid delays vocal fold separation and induces load-related vocal fold mucosa remodeling
Drainage of amniotic fluid delays vocal fold separation and induces load-related vocal fold mucosa remodeling Open
View article: Mechanisms of larynx and vocal fold development and pathogenesis
Mechanisms of larynx and vocal fold development and pathogenesis Open
View article: Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure Open
View article: β-Catenin signaling is essential for mammalian larynx recanalization and the establishment of vocal fold progenitor cells
β-Catenin signaling is essential for mammalian larynx recanalization and the establishment of vocal fold progenitor cells Open
Congenital laryngeal webs result from failure of vocal fold separation during development in utero. Infants present with life-threatening respiratory problems at birth, and extensive lifelong difficulties in breathing and voicing. The mole…
View article: Ontogeny of the mouse vocal fold epithelium
Ontogeny of the mouse vocal fold epithelium Open