V.M. Pushkarev
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Effect of Treatment with Sodium-dependent Glucose Cotransporter Type 2 Inhibitors on the Levels of Oxidized Low-density Lipoproteins, Interleukin 17A, and Lipoprotein (a) in the Blood of Diabetic Patients who Have Recovered from COVID-19 Open
Diabetes mellitus (DM) and cardiovascular disease (CVD) are factors that complicate the course of COVID-19, and the last one provokes further complications of these diseases. Oxidized low-density lipoproteins (oxLDL) play a crucial role in…
Tight junction protein ZO-1 as a possible marker of metastasis in thyroid carcinomas: a review of the literature and our own data Open
The plasticity of epithelial cells, exemplified by the epithelial-mesenchymal transition, has a crucial impact on tumorigenesis and metastasis. A key event in the epithelial-mesenchymal transition is the reorganization of intercellular ju…
Transforming growth factor beta 1 level in differentiated thyroid tumors, metastases and blood plasma Open
Background. One of the most important tasks facing endocrine surgery is the determination of reliable markers of metastasis in the treatment of papillary thyroid carcinoma (PTC). Markers that can be determined at the stage of preoperative …
Агоністи рецепторів глюкагоноподібного пептиду-1 у лікуванні захворювань серцево-судинної системи в пацієнтів із цукровим діабетом Open
Antidiabetic agents with lipid-modulating effects, such as metformin, GLP-1 (glucagon-like peptide-1) agonists, and SGLT2 (sodium-glucose cotransporter-2) inhibitors, which are able to induce EAT regression, may be particularly effective i…
MATHEMATICAL MODEL AS A METHOD OF EVALUATING THE ACTIVATION OF ONCOGENESIS IN PATIENTS WITH TYPE 2 DIABETES Open
Introduction. Numerous studies have proven the link between diabetes and cancer. Chronic metabolic disorders in type 2 diabetes (T2D) cause dysregulation of intracellular systems involved in the control of cell survival, apoptosis, and pro…
Heart Failure with Preserved Ejection Fraction in Patients with Diabetes Mellitus. Treatment with Sodium-Glucose Cotransporter-2 Inhibitors Open
The prolonged physiological stress can lead to adverse cardiorenal complications, including cardiomyopathy, heart failure (HF), and chronic kidney disease (CKD). Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are approved for the treat…
ZEB1 as a marker of metastasis in thyroid carcinomas: review of literature and own data Open
Metastases are the leading cause of death from malignant tumors. The metastatic process involves the exit of cancer cells from the primary tumor into the blood or other transport system, colonization and proliferation in a distant organ. T…
Pathogenetic basis of treating endothelial dysfunction with metformin in patients with diabetes (literature review and own data) Open
Cardiovascular disorders are one of the leading causes of mortality and morbidity worldwide, and their likelihood increases with the addition of risk factors such as sedentary lifestyle, diabetes, obesity, hyperlipidemia, and hypertension.…
Серцева недостатність зі збереженою фракцією викиду: основні молекулярні і клітинні механізми розвитку Open
Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and symptoms of heart failure in the presence of a normal left ventricular ejection fraction. HFpEF is a heterogeneous syndrome with diverse etiology and path…
Effect of sodium-dependent glucose cotransporter type 2 inhibitors on lipid metabolism in patients with diabetes mellitus (literature review) Open
EFFECT OF SODIUM-DEPENDENT GLUCOSE COTRANSPORTER TYPE 2 INHIBITORS ON LIPID METABOLISM IN PATIENTS WITH DIABETES MELLITUS (literature review) Nataliia I. Levchuk, Olena I. Kovzun, Volodymyr M. Pushkarev, Mykola D. Tronko State Institution …
THE MAIN SIGNALING SYSTEMS INVOLVED IN THE FUNCTIONING OF STEM CELLS (review of literature data) Open
Modern hormone replacement therapy for endocrine disorders cannot reproduce the complex interactions of hormones. Cell transplantation is a more physiological approach to the treatment of endocrine gland dysfunction. The data obtained indi…
Effects of COVID-19 and diabetes mellitus on AMPKα1 and IRS-1 amount in the blood plasma of patients Open
The aim of the study was to determine the levels of AMPKα1 and IRS-1 in the blood of patients with diabetes mellitus and COVID-19. AMPKα1 and IRS-1 were determined using enzyme-linked immunosorbent assay (ELISA) (Elabscience, USA). AMPK co…
Epigenetics, cell cycle and stem cell metabolism. Formation of insulin-producing cells Open
Stem cell (SC) differentiation requires a series of chromatin rearrangements to establish cell identity. Posttranslational modifications of histones usually regulate the dynamics of heterochromatin. Histones are subjected to various modifi…
Apolipoprotein B and oxLDL levels in plasma of patients with diabetes, cardiovascular disease, and COVID-19 Open
Elevated levels of low-density lipoprotein (LDL-X) cholesterol, apolipoprotein B (ApoB), and especially oxidized LDL in plasma are associated with an increased risk of cardiovascular disease (CVD). The aim of the study was to determine the…
Plasma Apolipoproteins A1/B and OxLDL Levels in Patients with Covid-19 As Possible Markers of the Disease Open
The COVID-19 infection is associated with dyslipidemia and cardiovascular complications. The aim of the study was to determine the content of ApoA1, ApoB, and oxidized low-density lipoproteins (oxLDL) in the plasma of patients (n = 81) wit…
Effects of COVID-19, diabetes mellitus, and cardiovascular diseases on insulin receptor substrate-1 amount in the blood plasma of patients Open
Insulin receptor substrate (IRS) is a key adapter protein mediating effects of insulin and insulin-like growth factors (IGF) in cells. IRS-1 is a member of the insulin receptor substrate family, which is associated with tumor initiation an…
Effects of COVID-19 and diabetes mellitus on apolipoprotein A1 level in the blood plasma of patients Open
Background. Increased level of high-density lipoprotein (HDL) cholesterol and apolipoprotein A1 (ApoA1) in plasma is associated with a reduced risk of developing cardiovascular diseases. In addition to its potential cardioprotective functi…
Effects of vitamin D in thyroid autoimmune pathologies: literature review and own data Open
Background. Vitamin D (VD) is a versatile steroid hormone that regulates the activity of several thousand genes. Over the past decades, numerous diseases associated with VD deficiency have been reported, including cancer and autoimmune thy…
Apolipoprotein A1 Level in Plasma of Patients with Diabetes and Diabetic Patients with COVID-19 as a Possible Marker of Disease Open
Increased levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) in plasma is associated with a reduced risk of developing cardiovascular diseases (CVD). In addition to its potential cardio- protective functio…
Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease Open
Increased levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) in plasma is associated with a reduced risk of developing cardiovascular diseases (CVD). In addition to its potential cardioprotective function,…
Study of the Association Between Antihyperglycemic Therapy and Cancer in Patients with Type 2 Diabetes Mellitus Open
The objective of the research was to investigate the features and association of antihyperglycemic therapy and cancer in patients with type 2 diabetes mellitus. Materials and Methods. The study included the analysis of medical records of p…
The effect of obesity on the formation of cancer risk in patients with type 2 diabetes mellitus (literature review) Open
The increased risk of cancer in patients with type 2 diabetes mellitus substantiates the relevance of scientific researches on the mechanisms of association of these diseases. It was found that pathogenetic factors of type 2 diabetes melli…
Phosphorylation of Protein Kinase Akt by Mtorc2 in Peripheral Blood Mononuclear Cells of Patients with Cancer and Diabetes Open
Akt/mTOR/p70S6K1 signaling pathway plays an important role in the pathogenesis of cancer and diabetes. Macrophages and lymphocytes are involved in the pathogenesis of diabetes, diabetic atherosclerosis, formation of insulin resistance as w…
Reception and intracellul ar mechanisms of insulin action (part 2) Open
The review analyzes the mechanisms involved in the reception and transduction of insulin signals in target cells. The structure of the receptor, the mechanism of its activation and the transduction of the hormone signal to the downstream c…
Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTOR, and p70S6K protein kinases in lymphocytes of diabetic patients Open
The expression of the main effector protein kinase Akt of the PI3K signaling pathway and the activities of mTOR and p70S6K protein kinases in lymphocytes of patients with diabetes mellitus are determined at the combination treatment with i…
Biochemical aspects of the combined use of taxanes, irradiation and other antineoplastic agents for the treatment of anaplastic thyroid carcinoma Open
The review summarizes the results of the cycle of own research and literature data on biochemical mechanisms of combined action of taxanes with γ-irradiation and other antineoplastic agents on one of the most aggressive types of human canc…
Reception and intracellular mechanisms of insulin action Open
The review analyzes the mechanisms involved in the reception and transduction of insulin signals in the target cells. The structure of the receptor, the mechanism of its activation and the transduction of the hormone signal to the downstre…
Вплив лазерного опромінення (384 нм) карциноми легенів Льюїс на розмір пухлини і утворення метастазів Open
We study the effect of laser irradiation upon implanted Lewis carcinoma. The irradiation of mice with Lewis carcinoma by a femtosecond pulsed laser with a wavelength of 384 nm was performed. Four groups of animals with different irradiatio…