Vojtěch Pražák
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View article: Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses
Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses Open
Communication between cellular organelles is essential for mounting effective innate immune responses. The transport of organelles to pathogen penetration sites and their assembly around the host membrane, which delineates the plant–pathog…
View article: Subcellular reorganization upon phage infection reveals stepwise assembly of viral particles from membrane-associated precursors
Subcellular reorganization upon phage infection reveals stepwise assembly of viral particles from membrane-associated precursors Open
Summary paragraph Viruses are obligate intracellular parasites and viral infections lead to massive host cell rearrangement to support the rapid generation of progeny. Host take-over and remodelling include formation of viral-induced compa…
View article: Molecular architecture of glideosome and nuclear F-actin in Plasmodium falciparum
Molecular architecture of glideosome and nuclear F-actin in Plasmodium falciparum Open
View article: Infection-induced peripheral mitochondria fission drives ER encapsulations and inter-mitochondria contacts that rescue bioenergetics
Infection-induced peripheral mitochondria fission drives ER encapsulations and inter-mitochondria contacts that rescue bioenergetics Open
View article: Molecular plasticity of herpesvirus nuclear egress analysed in situ
Molecular plasticity of herpesvirus nuclear egress analysed in situ Open
View article: Molecular architecture of glideosome and nuclear F-actin in<i>Plasmodium falciparum</i>
Molecular architecture of glideosome and nuclear F-actin in<i>Plasmodium falciparum</i> Open
Actin-based motility is required for the transmission of malaria sporozoites. While this has been shown biochemically, filamentous actin has remained elusive and has to date never been directly visualised inside the parasite. Using focused…
View article: The palisade layer of the poxvirus core is composed of flexible A10 trimers
The palisade layer of the poxvirus core is composed of flexible A10 trimers Open
View article: NECing goes: flexibility of the herpesvirus nuclear egress complex
NECing goes: flexibility of the herpesvirus nuclear egress complex Open
The nuclear egress complex (NEC) allows herpesvirus capsids to escape from the nucleus without breaking the nuclear envelope barrier. It assembles into a lattice on the inner nuclear membrane enveloping newly assembled nucleocapsids, which…
View article: THE PALISADE LAYER OF THE POXVIRUS CORE IS COMPOSED OF FLEXIBLE A10-TRIMERS
THE PALISADE LAYER OF THE POXVIRUS CORE IS COMPOSED OF FLEXIBLE A10-TRIMERS Open
Although vaccinia virus (VACV) is the best studied poxvirus, the structure of the mature virus (MV) remains poorly understood. Its asymmetric shape, size and compactness poses a major challenge for electron microscopy (EM) analysis, includ…
View article: Variable microtubule architecture in the malaria parasite
Variable microtubule architecture in the malaria parasite Open
Microtubules are a ubiquitous eukaryotic cytoskeletal element typically consisting of 13 protofilaments arranged in a hollow cylinder. This arrangement is considered the canonical form and is adopted by most organisms, with rare exceptions…
View article: The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield
The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield Open
Mimivirus is the prototype of the Mimiviridae family of giant dsDNA viruses. Little is known about the organization of the 1.2 Mb genome inside the membrane-limited nucleoid filling the ~0.5 µm icosahedral capsids. Cryo-electron microscopy…
View article: Author response: The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield
Author response: The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mimivirus is the proto…
View article: Form follows function: Variable microtubule architecture in the malaria parasite
Form follows function: Variable microtubule architecture in the malaria parasite Open
The malaria parasite undergoes a series of extensive morphological changes within its human host and mosquito vector. A scaffold of microtubules beneath a peripheral double membrane establishes and maintains the distinct shapes of all infe…
View article: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield
The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield Open
Mimivirus is the prototype of the Mimiviridae family of giant dsDNA viruses. Little is known about the organization of the 1.2 Mb genome inside the membrane-limited nucleoid filling the ∼0.5 µm icosahedral capsids. Cryo-electron microscopy…
View article: DNA origami signposts for identifying proteins on cell membranes by electron cryotomography
DNA origami signposts for identifying proteins on cell membranes by electron cryotomography Open
View article: The prefusion structure of herpes simplex virus glycoprotein B
The prefusion structure of herpes simplex virus glycoprotein B Open
Elusive, pharmacologically relevant conformation of the herpesvirus fusion protein is revealed by a multi-methodological approach.
View article: Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity
Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity Open
Bactericidal perforin-2 assembles an inactivated pre-pore complex and undergoes a 180° reconfiguration for membrane attack.
View article: Improvements in electron cryo-tomography towards understanding virus surfing
Improvements in electron cryo-tomography towards understanding virus surfing Open
Electron cryo-tomography (cET), in combination with sub‑volume averaging (SVA), is a powerful technique for determining the structure of complex biological specimens that are not amenable to more traditional structure determination methods…
View article: Cryo EM structure of the rabies virus ribonucleoprotein complex
Cryo EM structure of the rabies virus ribonucleoprotein complex Open
View article: Cryo-SOFI enabling low-dose super-resolution correlative light and electron cryo-microscopy
Cryo-SOFI enabling low-dose super-resolution correlative light and electron cryo-microscopy Open
Correlative light and electron cryo-microscopy (cryo-CLEM) combines information from the specific labeling of fluorescence cryo-microscopy (cryo-FM) with the high resolution in environmental context of electron cryo-microscopy (cryo-EM). E…
View article: The Structure of YnaI Implies Structural and Mechanistic Conservation in the MscS Family of Mechanosensitive Channels
The Structure of YnaI Implies Structural and Mechanistic Conservation in the MscS Family of Mechanosensitive Channels Open