Vojtěch Thon
YOU?
Author Swipe
View article: Sampling frequency matters: mapping of the healthy infants' gut microbiome during the first year of life
Sampling frequency matters: mapping of the healthy infants' gut microbiome during the first year of life Open
Background Previous studies described the impact of various early life events on the developing gut environment of infants. Nevertheless, a comprehensive understanding of the time frame of the response of the healthy microbiome to specific…
View article: Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment
Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment Open
In the first days of life, the newborns’ intestinal microbiota develops simultaneously with the intestinal gut barrier and follows intestinal immunity. The mode of delivery shows significant impact on microbial development and, thus, the i…
Primary ciliary dyskinesia as a rare cause of male infertility – case report and literature overview Open
Background: Primary ciliary dyskinesia (PCD) is a heterogenous disease caused by mutations of miscellaneous genes which physiologically play an important role in proper structure and/or function of various cellular cilia including sperm fl…
Altered Transcriptome Response in PBMCs of Czech Adults Linked to Multiple PFAS Exposure: B Cell Development as a Target of PFAS Immunotoxicity Open
While the immunomodulation effects of per- and polyfluoroalkyl substances (PFASs) are described on the level of clinical signs in epidemiological studies (e.g., suppressed antibody response after vaccination), the underlying mechanism has …
Peripheral Blood Transcriptome Profiles of Adults with Type I Hypersensitivity Open
Allergy of type I hypersensitivity affects about 150 million people in Europe. It is clinically manifested as atopic dermatitis, conjunctivitis, rhinitis, rhinoconjunctivitis, and allergic asthma. However, the underlying mechanisms occurri…
Investigation of SARS-CoV-2 seroprevalence in relation to natural infection and vaccination between October 2020 and September 2021 in the Czech Republic: a prospective national cohort study Open
Objective Examine changes in SARS-CoV-2 seropositivity before and during the national vaccination campaign in the Czech Republic. Design Prospective national population-based cohort study. Setting Masaryk University, RECETOX, Brno. Partici…
View article: Titanium Dioxide Nanoparticles Modulate Systemic Immune Response and Increase Levels of Reduced Glutathione in Mice after Seven-Week Inhalation
Titanium Dioxide Nanoparticles Modulate Systemic Immune Response and Increase Levels of Reduced Glutathione in Mice after Seven-Week Inhalation Open
Titanium dioxide nanoparticles (TiO2 NPs) are used in a wide range of applications. Although inhalation of NPs is one of the most important toxicologically relevant routes, experimental studies on potential harmful effects of TiO2 NPs usin…
Neonatal Diet and Gut Microbiome Development After C-Section During the First Three Months After Birth: A Systematic Review Open
Background Cesarean section (C-section) delivery imprints fundamentally on the gut microbiota composition with potential health consequences. With the increasing incidence of C-sections worldwide, there is a need for precise characterizati…
Prospective investigation of SARS-CoV-2 seroprevalence in relation to natural infection and vaccination between October 2020 and September 2021 in the Czech Republic Open
Purpose Monitoring the seroprevalence of COVID-19 antibodies is an important tool to design and adjust preventive strategies. We used prospective data on a large population sample with repeated IgG antibody measurement to examine changes i…
Analysis of cerebrospinal fluid cells by flow cytometry: Comparison to conventional cytology Open
Even normal CSF samples are amenable to basic mononuclear cell subpopulation analysis by FC. However, analysis of the B-cell subpopulations requires either a larger sample volume or selection of samples with ≥ 3 cells/μL.
View article: Copper Oxide Nanoparticles Stimulate the Immune Response and Decrease Antioxidant Defense in Mice After Six-Week Inhalation
Copper Oxide Nanoparticles Stimulate the Immune Response and Decrease Antioxidant Defense in Mice After Six-Week Inhalation Open
Copper oxide nanoparticles (CuO NPs) are increasingly used in various industry sectors. Moreover, medical application of CuO NPs as antimicrobials also contributes to human exposure. Their toxicity, including toxicity to the immune system …
Nationwide increases in anti-SARS-CoV-2 IgG antibodies between October 2020 and March 2021 in the unvaccinated Czech population Open
Background The aim of the nationwide prospective seroconversion (PROSECO) study was to investigate the dynamics of anti-SARS-CoV-2 IgG antibodies in the Czech population. Here we report on baseline prevalence from that study. Methods The s…
View article: Profiling Tryptophan Catabolites of Human Gut Microbiota and Acute-Phase Protein Levels in Neonatal Dried Blood Specimens
Profiling Tryptophan Catabolites of Human Gut Microbiota and Acute-Phase Protein Levels in Neonatal Dried Blood Specimens Open
National screening programs use dried blood specimens to detect metabolic disorders or aberrant protein functions that are not clinically evident in the neonatal period. Similarly, gut microbiota metabolites and immunological acute-phase p…
Dynamics of seroconversion of anti-SARS-CoV-2 IgG antibodies in the Czech unvaccinated population: nationwide prospective seroconversion (PROSECO) study Open
Background Although the Czech Republic weathered the first wave of the COVID-19 epidemic with relatively low incidence, the second wave of the global pandemic saw it rank among countries bearing the greatest COVID-19 burden, both in Europe…
Simultaneous quantitative profiling of clinically relevant immune markers in neonatal stool swabs to reveal inflammation Open
An aberrant immune response developed early in life may trigger inflammatory bowel disease (IBD) and food allergies (e.g., celiac disease). Fecal levels of immune markers categorize an inflammatory response (e.g., food allergy, autoimmune)…
A Model of Perinatal Stress and Childhood Wheezing: ELSPAC-CZ Cohort Open
Background Prenatal origins of wheezing are not fully understood. This study develops a model of mechanisms linking perinatal stress exposure to wheeze phenotypes in children. Methods Data were obtained from 1,849 mother-child dyads partic…
The pitfalls of treating rapidly evolving multiple sclerosis Open
3 RECETOX, Přírodovědecká fakulta Masarykovy univerzity a AKIMED
View article: Antibodies against Pneumococcal Capsular Polysaccharides and Natural Anti-Galactosyl (Alpha-Gal) in Patients with Humoral Immunodeficiencies
Antibodies against Pneumococcal Capsular Polysaccharides and Natural Anti-Galactosyl (Alpha-Gal) in Patients with Humoral Immunodeficiencies Open
Humoral deficiencies represent a broad group of disorders. The aim of the study was to compare the levels of antibodies against pneumococcal capsular polysaccharides (anti-PCP) and natural anti-galactosyl (anti-Gal) antibodies in (1) patie…
Immunological outlook on modern therapy of multiple sclerosis Open
Ústav klinické imunologie a alergologie LF MU a FN u sv.Anny, Centrum pro výzkum toxických látek v prostředí (RECETOX) Přírodovědecké fakulty Masarykovy
Teriflunomide in treating relapsing-remitting multiple sclerosis - immunomodulatory mechanisms Open
Ústav klinické imunologie a alergologie Lékařské fakulty Masarykovy univerzity a FN u sv.Anny