Václav Vaněk
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View article: 3D Scanning Technology as a Key for Quality Control and Precision in Civil Engineering 3DCP Construction
3D Scanning Technology as a Key for Quality Control and Precision in Civil Engineering 3DCP Construction Open
This paper focuses on new application methods, with an emphasis on Additive Manufacturing and especially on 3D Concrete Printing. As concrete printing is a “living material”, there is a need for continuous quality and accuracy control, wit…
View article: Specific Requirements for Technical Documentation in the Automotive Industry
Specific Requirements for Technical Documentation in the Automotive Industry Open
This paper focuses on solving some of the problems arising in the design process groups in the automotive industry.The geometrical specification of machine parts in the automotive industry creates a number of problems, the solutions of whi…
View article: Metastable Brominated Nanodiamond Surface Enables Room Temperature and Catalysis-Free Amine Chemistry
Metastable Brominated Nanodiamond Surface Enables Room Temperature and Catalysis-Free Amine Chemistry Open
Bromination of high-pressure, high-temperature (HPHT) nanodiamond (ND) surfaces has not been explored and can open new avenues for increased chemical reactivity and diamond lattice covalent bond formation. The large bond dissociation energ…
View article: A metastable brominated nanodiamond surface enables room temperature and catalysis-free amine chemistry
A metastable brominated nanodiamond surface enables room temperature and catalysis-free amine chemistry Open
Bromination of high-pressure high-temperature (HPHT) nanodiamond (ND) surfaces has not been explored and can open new avenues for increased chemical reactivity and diamond lattice covalent bond formation. The large bond dissociation energy…
View article: Determination of the Measurement Deviation
Determination of the Measurement Deviation Open
Tento článek se zabývá stanovením odchylek měření v mechanických zkušebních laboratořích. Hlavním problémem je výpočet těchto odchylek měření, v přijatelném čase a vytvoření záznamu o tomto procesu. Většina měření obsahuje více odchylek, k…
View article: Insulin-like Growth Factor 1 Analogs Clicked in the C Domain: Chemical Synthesis and Biological Activities
Insulin-like Growth Factor 1 Analogs Clicked in the C Domain: Chemical Synthesis and Biological Activities Open
Human insulin-like growth factor 1 (IGF-1) is a 70 amino acid protein hormone, with key impact on growth, development, and lifespan. The physiological and clinical importance of IGF-1 prompted challenging chemical and biological trials tow…
View article: Rational steering of insulin binding specificity by intra-chain chemical crosslinking
Rational steering of insulin binding specificity by intra-chain chemical crosslinking Open
Insulin is a key hormone of human metabolism with major therapeutic importance for both types of diabetes. New insulin analogues with more physiological profiles and better glycemic control are needed, especially analogues that preferentia…
View article: A CuAAC–Hydrazone–CuAAC Trifunctional Scaffold for the Solid-Phase Synthesis of Trimodal Compounds: Possibilities and Limitations
A CuAAC–Hydrazone–CuAAC Trifunctional Scaffold for the Solid-Phase Synthesis of Trimodal Compounds: Possibilities and Limitations Open
We present a trifunctional scaffold designed for the solid-phase synthesis of trimodal compounds. This scaffold holds two alkyne arms in a free and TIPS-protected form for consecutive CuAAC (copper(I)-catalyzed azide–alkyne cycloaddition),…