Volker Mailänder
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View article: Unfolding and Degradation of Micellar Immunodrug Carriers Derived From End Group Modified Aliphatic Poly(Carbonate)s with Acid‐Responsive Ketal Side Groups
Unfolding and Degradation of Micellar Immunodrug Carriers Derived From End Group Modified Aliphatic Poly(Carbonate)s with Acid‐Responsive Ketal Side Groups Open
Small‐molecule immunodrugs hold significant promise for immunotherapeutic applications including vaccination and cancer therapy. However, their clinical use is limited by severe side effects resulting from systemic distribution. To address…
View article: Continuous phase hydrophobicity exerts substantial influence on the surface functional group prevalence in protein nanocapsules synthesized in inverse miniemulsion
Continuous phase hydrophobicity exerts substantial influence on the surface functional group prevalence in protein nanocapsules synthesized in inverse miniemulsion Open
Precise control over the nanocarrier surface properties is crucial for biomedical applications. Here, we demonstrate how the surface functional group density of protein nanocapsules can be tuned systematically via the continuous phase hydr…
View article: The Distribution of Complement Proteins in Soft and Hard Coronas Impacts Macrophage Uptake of Nanoparticles
The Distribution of Complement Proteins in Soft and Hard Coronas Impacts Macrophage Uptake of Nanoparticles Open
Complement proteins, as key constituents of the protein corona, facilitate the elimination of exogenous nanoparticles by immune cells, thereby limiting their tumor accumulation and therapeutic efficacy. Current research on complement prote…
View article: Physiological pH Transition‐Driven Protein Corona Dynamics Regulate Cellular Uptake and Inflammatory Responses of Silica Nanoparticles
Physiological pH Transition‐Driven Protein Corona Dynamics Regulate Cellular Uptake and Inflammatory Responses of Silica Nanoparticles Open
Protein corona alters the biological identities and interactions of nanoparticles with cells, needing to be thoroughly scrutinized before in vivo applications. Importantly, protein corona is evolving as nanoparticles cross different microe…
View article: Integrating incompatible tandem photobiocatalysis in artificial cells enables metabolic modulation of natural cells
Integrating incompatible tandem photobiocatalysis in artificial cells enables metabolic modulation of natural cells Open
Sustaining biological reactions in artificial cells is crucial for their practical integration into living systems, which relies on continuous cofactor supply. Although photocatalysis enables cofactor regeneration in synthetic biological s…
View article: Protein corona fingerprinting of exocytosed nanoparticles reveals time-dependence of exocytosis pathways
Protein corona fingerprinting of exocytosed nanoparticles reveals time-dependence of exocytosis pathways Open
In the field of nano-bio interactions, the cellular uptake of nanocarriers and the modulating factors, e.g. the presence of a protein shell - the protein corona - adsorbed on the nanocarrier surface are well studied. However, little is kno…
View article: Interfacing with the Brain: How Nanotechnology Can Contribute
Interfacing with the Brain: How Nanotechnology Can Contribute Open
Interfacing artificial devices with the human brain is the central goal of neurotechnology. Yet, our imaginations are often limited by currently available paradigms and technologies. Suggestions for brain-machine interfaces have changed ov…
View article: Plasma protein corona on silica nanoparticles enhances exocytosis
Plasma protein corona on silica nanoparticles enhances exocytosis Open
The influence of a pre-adsorbed human plasma protein corona on the exocytosis of silica nanoparticles (SiNP) is reported. SiNPs with a pre-adsorbed protein corona are exocytosed rapidly depending also on the composition of the adsorbed pro…
View article: Multi-Omic Data Integration Suggests Putative Microbial Drivers of Aetiopathogenesis in Mycosis Fungoides
Multi-Omic Data Integration Suggests Putative Microbial Drivers of Aetiopathogenesis in Mycosis Fungoides Open
Background: Mycosis fungoides (MF) represents the most prevalent entity of cutaneous T cell lymphoma (CTCL). The MF aetiopathogenesis is incompletely understood, due to significant transcriptomic heterogeneity and conflicting views on whet…
View article: Nanobodies Outperform Antibodies – Rapid Functionalization with Equal In Vivo Targeting Properties
Nanobodies Outperform Antibodies – Rapid Functionalization with Equal In Vivo Targeting Properties Open
Highly specific targeting of dendritic cells in vivo is crucial for the development of effective tumor nanovaccines. This group recently presented an antibody‐functionalized nanocarrier system able to maintain its targeting properties when…
View article: The ENDOMIX perspective: how everyday chemical mixtures impact human health and reproduction by targeting the immune system
The ENDOMIX perspective: how everyday chemical mixtures impact human health and reproduction by targeting the immune system Open
Endocrine-disrupting chemicals are natural and synthetic compounds found ubiquitously in the environment that interfere with the hormonal-immune axis, potentially impacting human health and reproduction. Exposure to endocrine-disrupting ch…
View article: The ENDOMIX perspective: how everyday chemical mixtures impact human health and reproduction by targeting the immune system
The ENDOMIX perspective: how everyday chemical mixtures impact human health and reproduction by targeting the immune system Open
Endocrine disruptoring chemicals (EDCs) are natural and synthetic compounds found ubiquitously in the environment that interfere with the hormonal-immune axis, potentially impacting human health and reproduction. Exposure to EDCs has been …
View article: Process Control of Multistep Surface Functionalization on Hydroxyethyl Starch Nanocapsules Determines the Reproducibility of the Biological Efficacy
Process Control of Multistep Surface Functionalization on Hydroxyethyl Starch Nanocapsules Determines the Reproducibility of the Biological Efficacy Open
[Image: see text] Nanocarrier synthesis is highly process-dependent, leading to potential batch-to-batch variability if it is not controlled at each step. This variability affects the reproducibility of subsequent biomodification, resultin…
View article: Controlled Functionalization Strategy of Proteins Preserves their Structural Integrity While Binding to Nanocarriers
Controlled Functionalization Strategy of Proteins Preserves their Structural Integrity While Binding to Nanocarriers Open
The use of proteins as targeting agents often requires their chemical modification for their efficient attachment to a given surface. However, no control over the protein integrity and functionality has been demonstrated to date. Chemical …
View article: Interfacial Denaturation at the Droplet Simplifies the Formation of Drug‐Loaded Protein Nanocapsules to Enhance Immune Response of Cells
Interfacial Denaturation at the Droplet Simplifies the Formation of Drug‐Loaded Protein Nanocapsules to Enhance Immune Response of Cells Open
Nanocapsules enable multicomponent encapsulation of therapeutic cargoes with high encapsulation content and efficiency, which is vital for cancer immunotherapy. In the past, chemical crosslinking is used to synthesize nanocapsules, which c…
View article: Multiomic Data Integration Reveals Microbial Drivers of Aetiopathogenesis in Mycosis Fungoides
Multiomic Data Integration Reveals Microbial Drivers of Aetiopathogenesis in Mycosis Fungoides Open
Background Mycosis fungoides (MF) represents the most prevalent entity of cutaneous T cell lymphoma (CTCL). The MF aetiopathogenesis is incompletely understood, due to strong transcriptomic heterogeneity and opposing perspectives on the in…
View article: Therapeutic applications of responsive organic photocatalytic polymers, enabling <i>in situ</i> drug activation
Therapeutic applications of responsive organic photocatalytic polymers, enabling <i>in situ</i> drug activation Open
Targeted prodrug activation within the acidic tumour microenvironment using pH-responsive photocatalytic nanomaterials.
View article: Nuclear Glycoprotein A Repetitions Predominant (GARP) Is a Common Trait of Glioblastoma Stem-like Cells and Correlates with Poor Survival in Glioblastoma Patients
Nuclear Glycoprotein A Repetitions Predominant (GARP) Is a Common Trait of Glioblastoma Stem-like Cells and Correlates with Poor Survival in Glioblastoma Patients Open
Glioblastoma (GB) is notoriously resistant to therapy. GB genesis and progression are driven by glioblastoma stem-like cells (GSCs). One goal for improving treatment efficacy and patient outcomes is targeting GSCs. Currently, there are no …
View article: Uptake of extracellular vesicles into immune cells is enhanced by the protein corona
Uptake of extracellular vesicles into immune cells is enhanced by the protein corona Open
The influence of a protein corona on the uptake of nanoparticles in cells has been demonstrated in various publications over the last years. Extracellular vesicles (EVs), can be seen as natural nanoparticles. However, EVs are produced unde…
View article: Delivery of Immunostimulatory Cargos in Nanocarriers Enhances Anti-Tumoral Nanovaccine Efficacy
Delivery of Immunostimulatory Cargos in Nanocarriers Enhances Anti-Tumoral Nanovaccine Efficacy Open
Finding a long-term cure for tumor patients still represents a major challenge. Immunotherapies offer promising therapy options, since they are designed to specifically prime the immune system against the tumor and modulate the immunosuppr…
View article: The Skin Microbiome Stratifies Patients with Cutaneous T Cell Lymphoma and Determines Event-Free Survival
The Skin Microbiome Stratifies Patients with Cutaneous T Cell Lymphoma and Determines Event-Free Survival Open
Background: Cutaneous T cell lymphomas (CTCL) are a heterogeneous group of non-Hodgkin lymphomas that are characterized by the presence of clonal malignant T cells in the skin, with Mycosis fungoides (MF) being the most common entity. The …
View article: Endosomal sorting results in a selective separation of the protein corona from nanoparticles
Endosomal sorting results in a selective separation of the protein corona from nanoparticles Open
The formation of the protein corona is a well-known effect when nanoparticles (NP) are exposed to biological environments. The protein corona is the most important factor, which determines the rate and route of endocytosis, and decisively …
View article: Anti-PEG antibodies enriched in the protein corona of PEGylated nanocarriers impact the cell uptake
Anti-PEG antibodies enriched in the protein corona of PEGylated nanocarriers impact the cell uptake Open
Anti-PEG antibodies present in blood samples of German donors were found to be enriched in the protein corona of PEGylated nanocarriers. This enrichment led to enhanced uptake in macrophages, counteracting the desired stealth effect of PEG.
View article: The Role of the Immune Phenotype in Tumor Progression and Prognosis of Patients with Mycosis Fungoides: A Quantitative Immunohistology Whole Slide Approach
The Role of the Immune Phenotype in Tumor Progression and Prognosis of Patients with Mycosis Fungoides: A Quantitative Immunohistology Whole Slide Approach Open
Background and objectives: Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphomas, characterized by mature, skin-tropic CD4+ T-helper cells. In order to study the immune tumor microenvironment in MF patients, we perfo…