Christine A. F. Von Arnim
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View article: The FORTA (Fit for the Aged) List 2024: Fifth Version of a Validated Clinical Aid for Improved Pharmacotherapy in Older Adults
The FORTA (Fit for the Aged) List 2024: Fifth Version of a Validated Clinical Aid for Improved Pharmacotherapy in Older Adults Open
View article: Alzheimer's disease and its co‐pathologies: Implications for hippocampal degeneration, cognitive decline, and the role of <i>APOE</i> ε4
Alzheimer's disease and its co‐pathologies: Implications for hippocampal degeneration, cognitive decline, and the role of <i>APOE</i> ε4 Open
INTRODUCTION In neurodegenerative dementias, the co‐occurrence and interaction of amyloid β peptide (Aβ), tau pathology, and other pathological lesions confound their individual contributions to neurodegeneration and their modulation by ri…
View article: Predicting Postoperative Delirium in Older Patients Before Elective Surgery: Multicenter Retrospective Cohort Study
Predicting Postoperative Delirium in Older Patients Before Elective Surgery: Multicenter Retrospective Cohort Study Open
Background Elective surgeries for older adults are increasing. Machine learning could enhance risk assessment, influencing surgical planning and postoperative care. Preoperative cognitive assessment may facilitate early detection and manag…
View article: Frailty’s influence on older stroke patients: Neurological outcome and mortality after endovascular treatment in stroke: A national German stroke registry analysis
Frailty’s influence on older stroke patients: Neurological outcome and mortality after endovascular treatment in stroke: A national German stroke registry analysis Open
Introduction: Frailty is a clinical syndrome particular in old patients with an increased risk of adverse health-care events. In geriatric stroke patients who received endovascular treatment, monocentric analyses have demonstrated that fra…
View article: Predicting one-year postoperative cognitive dysfunction after cardiac surgery by combining markers of amyloid-β and tau pathology
Predicting one-year postoperative cognitive dysfunction after cardiac surgery by combining markers of amyloid-β and tau pathology Open
View article: Alzheimer’s disease and its co-pathologies: implications for hippocampal degeneration, cognitive decline, and the role of <i>APOE</i> ε4
Alzheimer’s disease and its co-pathologies: implications for hippocampal degeneration, cognitive decline, and the role of <i>APOE</i> ε4 Open
INTRODUCTION In neurodegenerative dementias, the co-occurrence and interaction of Aβ, tau, and other pathological lesions confound their individual contributions to neurodegeneration and their modulation by risk factors. METHODS We analyze…
View article: Use of a Technology-Based Fall Prevention Program With Visual Feedback in the Setting of Early Geriatric Rehabilitation: Controlled and Nonrandomized Study
Use of a Technology-Based Fall Prevention Program With Visual Feedback in the Setting of Early Geriatric Rehabilitation: Controlled and Nonrandomized Study Open
Background The Otago program (OP) is evidence-based and focuses on fall prevention in older people. The feasibility and usability of a short-term digital program modeled after the principles of the OP in the setting of early geriatric reha…
View article: Intra- and early postoperative predictors of delirium risk in cardiac surgery: results from the prospective observational FINDERI study
Intra- and early postoperative predictors of delirium risk in cardiac surgery: results from the prospective observational FINDERI study Open
Background: Postoperative delirium (POD) is a severe complication following cardiac surgery and is associated with increased morbidity and mortality. The impact of intra- and early postoperative factors on the occurrence of POD following c…
View article: Depressive Symptoms and Amyloid Pathology
Depressive Symptoms and Amyloid Pathology Open
Importance Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association betwee…
View article: Deep clinical, genetic, and serum biomarker profiling indicates glial and neuronal pathology in primary brain calcification
Deep clinical, genetic, and serum biomarker profiling indicates glial and neuronal pathology in primary brain calcification Open
Primary brain calcification (primary familial brain calcification in inherited cases) is an often-genetic condition characterized by symmetrical brain calcifications and neuropsychiatric symptoms. The calcifications can also occur without …
View article: Cognitive decline and neuroinflammation in a mouse model of obesity: An accelerating role of ageing
Cognitive decline and neuroinflammation in a mouse model of obesity: An accelerating role of ageing Open
Obesity, a pandemic, worldwide afflicts almost one billion people. Obesity and ageing share several pathological pathways leading to neurological disorders. However, due to a lack of suitable animal models, the long-term effects of obesity…
View article: Correction: Pyroptosis in Alzheimer’s disease: cell type‑specific activation in microglia, astrocytes and neurons
Correction: Pyroptosis in Alzheimer’s disease: cell type‑specific activation in microglia, astrocytes and neurons Open
View article: pTau pathology in the retina of TAU58 mice: association with ganglion cell degeneration and implications on seeding and propagation of pTau from human brain lysates
pTau pathology in the retina of TAU58 mice: association with ganglion cell degeneration and implications on seeding and propagation of pTau from human brain lysates Open
The accumulation of abnormal phosphorylated Tau protein (pTau) in neurons of the brain is a pathological hallmark of Alzheimer's disease (AD). PTau pathology also occurs in the retina of AD cases. Accordingly, questions arise whether retin…
View article: Genome‐wide investigation of a neuropathological cohort offers novel insights in the genetic risk underlying hallmark and co‐morbid lesions implicated in Alzheimer’s disease
Genome‐wide investigation of a neuropathological cohort offers novel insights in the genetic risk underlying hallmark and co‐morbid lesions implicated in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is a heterogenous disease with a strong heritability. Genetic studies are of irreplaceable value in elucidating the mechanisms that underly this disease. The classical genome‐wide association studies (GW…
View article: Amygdala‐predominant α‐synuclein pathology accelerates CA1 neuron loss in Alzheimer’s disease
Amygdala‐predominant α‐synuclein pathology accelerates CA1 neuron loss in Alzheimer’s disease Open
Background In 43‐63% of symptomatic Alzheimer’s disease (AD) patients, there is an observed accumulation of misfolded alpha‐synuclein (αSyn). Two primary αSyn subtypes have been identified based on the underlying spreading pattern of this …
View article: Preoperative hypoxic biomarkers and postoperative delirium in patients with obstructive sleep apnea
Preoperative hypoxic biomarkers and postoperative delirium in patients with obstructive sleep apnea Open
View article: Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer’s-type dementia
Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer’s-type dementia Open
View article: Current Capacity for Diagnosing Alzheimer’s Disease in Germany and Implications for Wait Times
Current Capacity for Diagnosing Alzheimer’s Disease in Germany and Implications for Wait Times Open
Background: Amyloid-targeting therapies for Alzheimer’s disease (AD) might become available in Germany soon. The combination of a large pool of prevalent cases and a complex diagnostic process to determine eligibility for these treatments …
View article: Multimorbidität als Prädiktor für eine stationäre Aufnahme in der klinischen Notfall- und Akutmedizin
Multimorbidität als Prädiktor für eine stationäre Aufnahme in der klinischen Notfall- und Akutmedizin Open
Zusammenfassung Hintergrund Infolge der demografischen Entwicklung ist ein deutlicher Anstieg von multimorbiden Notfallpatient*innen in der klinischen Notfall- und Akutmedizin in Deutschland zu verzeichnen. Zur Definition operationalisierb…
View article: Erratum zu: Prävention des kognitiven Abbaus im Alter
Erratum zu: Prävention des kognitiven Abbaus im Alter Open
View article: Prävention des kognitiven Abbaus im Alter
Prävention des kognitiven Abbaus im Alter Open
There are currently 1.8 million people in Germany affected by dementia. Despite advances in research and new treatments, there is no cure for most cases of dementia. The evidence regarding the prevention of cognitive decline in old age is …
View article: Evaluation of frailty in geriatric patients undergoing cardiac rehabilitation after cardiac procedure: results of a prospective, cross-sectional study
Evaluation of frailty in geriatric patients undergoing cardiac rehabilitation after cardiac procedure: results of a prospective, cross-sectional study Open
Background Frailty is an indicator of a decline in quality of life and functional capacity in cardiac rehabilitation (CR) patients. Currently, there is no standardized assessment tool for frailty used in CR. The aim of this study was to de…
View article: Exploratory Tau PET/CT with [11C]PBB3 in Patients with Suspected Alzheimer’s Disease and Frontotemporal Lobar Degeneration: A Pilot Study on Correlation with PET Imaging and Cerebrospinal Fluid Biomarkers
Exploratory Tau PET/CT with [11C]PBB3 in Patients with Suspected Alzheimer’s Disease and Frontotemporal Lobar Degeneration: A Pilot Study on Correlation with PET Imaging and Cerebrospinal Fluid Biomarkers Open
Accurately diagnosing Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) is challenging due to overlapping symptoms and limitations of current imaging methods. This study investigates the use of [11C]PBB3 PET/CT imaging …
View article: Amygdala-predominant α-synuclein pathology exacerbates hippocampal neuron loss in Alzheimer’s disease
Amygdala-predominant α-synuclein pathology exacerbates hippocampal neuron loss in Alzheimer’s disease Open
Misfolded α-synuclein (αSyn) protein accumulates in 43-63% of individuals with symptomatic Alzheimer’s disease (AD). Two main patterns of co-morbid αSyn pathology have been identified: caudo-rostral and amygdala-predominant, with the latte…
View article: The Multidimensional Prognostic Index predicts incident delirium among hospitalized older patients with COVID-19: a multicenter prospective European study
The Multidimensional Prognostic Index predicts incident delirium among hospitalized older patients with COVID-19: a multicenter prospective European study Open
Purpose Incident delirium is a frequent complication among hospitalized older people with COVID-19, associated with increased length of hospital stay, higher morbidity and mortality rates. Although delirium is preventable with early detect…
View article: Which Comprehensive Geriatric Assessment (CGA) instruments are currently used in Germany: a survey
Which Comprehensive Geriatric Assessment (CGA) instruments are currently used in Germany: a survey Open
View article: ViaCogScreen: ein zeitökonomisches, valides und wiederholbares Screeningverfahren zum Leistungsmonitoring älterer Menschen
ViaCogScreen: ein zeitökonomisches, valides und wiederholbares Screeningverfahren zum Leistungsmonitoring älterer Menschen Open
Zusammenfassung Angesichts des demografischen Wandels in Deutschland mit einer alternden Gesellschaft ist eine kognitive Leistungsbewertung speziell des älteren Menschen von großer Bedeutung. Der von uns entwickelte Viacogscreen ist ein co…
View article: Predicting Postoperative Delirium in Older Patients: a multicenter retrospective cohort study
Predicting Postoperative Delirium in Older Patients: a multicenter retrospective cohort study Open
Background The number of elective surgeries for older individuals is on the rise globally. Machine learning may improve risk assessment with an impact on surgical planning and postoperative care. Preoperative cognitive assessment may facil…
View article: The prevalence and impact of sarcopenia in older cardiac patients undergoing inpatient cardiac rehabilitation – results from a prospective, observational cohort pre-study
The prevalence and impact of sarcopenia in older cardiac patients undergoing inpatient cardiac rehabilitation – results from a prospective, observational cohort pre-study Open
View article: Amygdala-predominant α-synuclein pathology is associated with exacerbated hippocampal neuron loss in Alzheimer’s disease
Amygdala-predominant α-synuclein pathology is associated with exacerbated hippocampal neuron loss in Alzheimer’s disease Open
Misfolded α-synuclein protein accumulates in 43–63% of individuals with symptomatic Alzheimer’s disease. Two main patterns of comorbid α-synuclein pathology have been identified: caudo-rostral and amygdala-predominant. α-Synuclein aggregat…