Vrinda Johri
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View article: SUN-565 High-dimensional Immunophenotyping of Immune Checkpoint Inhibitor-Induced Type 1 Diabetes
SUN-565 High-dimensional Immunophenotyping of Immune Checkpoint Inhibitor-Induced Type 1 Diabetes Open
Disclosure: Z. Quandt: None. S. Yellamilli: None. E. Flynn: None. V. Johri: None. B. Davidson: None. J. Tsui: None. A. Combes: None. G. Fragiadakis: None. A. Young: None. M. Anderson: None. Introduction: Immune checkpoint inhibitor (ICI) t…
View article: Transient Dietary Changes Modulate Inflammatory Disease Trajectory in the Lean State
Transient Dietary Changes Modulate Inflammatory Disease Trajectory in the Lean State Open
Obesity potently alters immune responses across various inflammatory contexts 1–7 . However, it is unclear whether a transient high-fat diet (HFD) can affect immune function despite minimal effects on body weight. Here, we demonstrate that…
View article: Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states
Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states Open
Human immune systems are highly variable, with most variation attributable to non-genetic sources. The gut microbiome crucially shapes the immune system; however, its relationship with the baseline immune states of healthy humans remains i…
View article: Single-cell spatial transcriptomics of fixed, paraffin-embedded biopsies reveals colitis-associated cell networks
Single-cell spatial transcriptomics of fixed, paraffin-embedded biopsies reveals colitis-associated cell networks Open
Background & Aims Imaging-based, single-cell spatial transcriptomics (iSCST) using formalin-fixed, paraffin-embedded (FFPE) tissue could transform translational research by retaining all tissue cell subsets and spatial locations while enab…
View article: Single-Cell Spatial Transcriptomics of Fixed, Paraffin-Embedded Biopsies Reveals Colitis-Associated Cell Networks
Single-Cell Spatial Transcriptomics of Fixed, Paraffin-Embedded Biopsies Reveals Colitis-Associated Cell Networks Open
View article: Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors
Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors Open
The anti-tumor function of CD8 T cells is limited through well-established pathways of T cell exhaustion (T EX ). Strategies to capture emergent functional states amongst this dominant trajectory of dysfunction are necessary to find pathwa…
View article: Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes Open