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View article: Myocardial work could be relevant in severe aortic stenosis: a new parameter for left ventricular function
Myocardial work could be relevant in severe aortic stenosis: a new parameter for left ventricular function Open
Background The left ventricle (LV) ejection fraction (EF) alone is no longer sufficient to define LV function in aortic stenosis. New echocardiografic parameters such as Global Longitudinal Strain (GLS) and Myocardial Work (MW) can provide…
View article: Effectiveness of PCSK9 inhibitors in homozygous familial hypercholesterolemia: insights from a Saudi Arabia genetic population
Effectiveness of PCSK9 inhibitors in homozygous familial hypercholesterolemia: insights from a Saudi Arabia genetic population Open
Homozygous familial hypercholesterolemia (HoFH) poses significant cardiovascular risk due to severely elevated low density lipoprotein choleterol (LDL-C) levels. While Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have …
View article: Homozygous familial hypercholesterolemia Evaluation and Survival study in Saudi Arabia (HESSA): genetic and molecular characteristics of the largest genetic cohort in the middle east
Homozygous familial hypercholesterolemia Evaluation and Survival study in Saudi Arabia (HESSA): genetic and molecular characteristics of the largest genetic cohort in the middle east Open
Homozygous Familial Hypercholesterolemia (HoFH) is a rare, genetic disorder caused by bi-allelic mutations in key genes responsible for lipid metabolism. This results in significantly elevated LDL-C levels, leading to early onset cardiovas…
View article: Genotype and cardiac outcome in patients with cardiocutaneous syndrome (Naxos disease variant: Carvajal syndrome)
Genotype and cardiac outcome in patients with cardiocutaneous syndrome (Naxos disease variant: Carvajal syndrome) Open
Background Naxos disease variant (Carvajal syndrome) is a cardiocutaneous genetic disease caused by Plakoglobin and Desmoplakin gene mutation, and usually manifests with woolly hair, palmoplantar keratoderma, and cardiomyopathy, and are fo…
View article: Aortic pseudoaneurysm with a fistula between the non-coronary sinus and right atrium: a case report
Aortic pseudoaneurysm with a fistula between the non-coronary sinus and right atrium: a case report Open
The authors present a case report of a 68-year-old man evaluated at the emergency department for repeated syncope, asthenia, and general malaise, suggesting heart failure in a patient with several comorbidities. At presentation, the patien…
View article: Clinical and echocardiographic predictors of outcome in liver transplant patients
Clinical and echocardiographic predictors of outcome in liver transplant patients Open
Liver transplant (LT) candidates undergo transthoracic echocardiography (TTE) before surgery to assess cardiac function and evaluate the echocardiographic probability of pulmonary hypertension (PHT). The improvement of pulmonary artery sys…
View article: The effects of mitral stenosis on right ventricular mechanics assessed by three-dimensional echocardiography
The effects of mitral stenosis on right ventricular mechanics assessed by three-dimensional echocardiography Open
Mitral stenosis (MS) is a complex valvular pathology with significant clinical burden even today. Its effect on the right heart is often overlooked, despite it playing a considerable part in the symptomatic status. We enrolled 39 mitral va…
View article: Pulmonary edema in a young male with severe uncontrolled cardiovascular risk factors and pan-vascular atherosclerosis: a case report
Pulmonary edema in a young male with severe uncontrolled cardiovascular risk factors and pan-vascular atherosclerosis: a case report Open
Cardiovascular risk factors are the cause of atherosclerotic disease, which can involve all the elastic and muscolo-elastic arteries. The etiopathogenesis of atherosclerosis is multifactorial since genetics, lifestyle, and comorbidities ca…
View article: Instability of Healthy Overweight and Obesity Phenotypes over the Long Term in Young Participants in the HARVEST Study: Influence of Sex
Instability of Healthy Overweight and Obesity Phenotypes over the Long Term in Young Participants in the HARVEST Study: Influence of Sex Open
Background: Whether healthy metabolic status is stable or only temporary is still controversial. The aim of the present study was to determine the frequency of the transition from metabolically healthy to metabolically unhealthy status, or…
View article: Takotsubo Syndrome in Black Americans: Insights From the National Inpatient Sample
Takotsubo Syndrome in Black Americans: Insights From the National Inpatient Sample Open
Background Data on race-related differences in the clinical outcomes of Takotsubo syndrome are limited, particularly for Black patients. This study aimed to assess whether race and sex may have an additional impact on the inpatient mortali…
View article: Arterial hypertension in patients with takotsubo syndrome: prevalence, long-term outcome, and secondary preventive strategies: a report from the Takotsubo Italian Network register
Arterial hypertension in patients with takotsubo syndrome: prevalence, long-term outcome, and secondary preventive strategies: a report from the Takotsubo Italian Network register Open
Aims The aim of this study was to investigate the long-term outcome of takotsubo syndrome (TTS) patients with and without hypertension (HT) and to evaluate the effectiveness of treatment with beta-blockers (BBs) and/or renin–angiotensin–al…
View article: Infective Endocarditis-Related Pseudoaneurysms after Bentall Surgery: The Role of 3D Printing in Pre-Surgical Planning and Management: Case Report
Infective Endocarditis-Related Pseudoaneurysms after Bentall Surgery: The Role of 3D Printing in Pre-Surgical Planning and Management: Case Report Open
We present a case report of a male patient who underwent modified Bentall surgery with a mechanical valved conduit due to severe aortic regurgitation and ascending aortic aneurysm. Four years later, the patient developed a cascade of event…
View article: Age-sex effect on in-hospital complications and mortality in patients with Takotsubo syndrome. Insights from the National Inpatient Sample
Age-sex effect on in-hospital complications and mortality in patients with Takotsubo syndrome. Insights from the National Inpatient Sample Open
Age and sex differences in Takotsubo syndrome (TTS) are still a matter of debate. The aim of the present study was to evaluate the difference in cardiovascular (CV) risk factors, CV disease, in-hospital complications, and death within diff…
View article: Both Moderate and Heavy Alcohol Use Amplify the Adverse Cardiovascular Effects of Smoking in Young Patients with Hypertension
Both Moderate and Heavy Alcohol Use Amplify the Adverse Cardiovascular Effects of Smoking in Young Patients with Hypertension Open
Aim: To evaluate the association of alcohol and smoking combined with cardiovascular and renal events and investigate whether moderate and heavy alcohol consumption have a different impact on this association. Methods: The study was conduc…
View article: Cardiovascular Side Effects of Anthracyclines and HER2 Inhibitors among Patients with Breast Cancer: A Multidisciplinary Stepwise Approach for Prevention, Early Detection, and Treatment
Cardiovascular Side Effects of Anthracyclines and HER2 Inhibitors among Patients with Breast Cancer: A Multidisciplinary Stepwise Approach for Prevention, Early Detection, and Treatment Open
Cardiovascular (CV) diseases (CVD) are a major cause of long-term morbidity and mortality affecting life expectancy amongst cancer survivors. In recent years, because of the possibility of early diagnosis and the increased efficacy of neo-…
View article: Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways
Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways Open
Early detection and treatment of cancer have led to a noticeable reduction in both mortality and morbidity. However, chemotherapy and radiotherapy could exert cardiovascular (CV) side effects, impacting survival and quality of life, indepe…
View article: Reproducibility and Predictive Value of White-Coat Hypertension in Young to Middle-Age Subjects
Reproducibility and Predictive Value of White-Coat Hypertension in Young to Middle-Age Subjects Open
(1) Aim. The aim of the study was to investigate the reproducibility of white-coat hypertension (WCH) and its predictive capacity for hypertension needing antihypertensive treatment (HT) in young to middle-age subjects. (2) Methods. We inv…
View article: Acute Heart Failure: Diagnostic–Therapeutic Pathways and Preventive Strategies—A Real-World Clinician’s Guide
Acute Heart Failure: Diagnostic–Therapeutic Pathways and Preventive Strategies—A Real-World Clinician’s Guide Open
Acute heart failure (AHF) is the most frequent cause of unplanned hospital admission in patients of >65 years of age and it is associated with significantly increased morbidity, mortality, and healthcare costs. Different AHF classification…
View article: Reciprocal interferences of the left ventricular assist device and the aortic valve competence
Reciprocal interferences of the left ventricular assist device and the aortic valve competence Open
Patients suffering from end-stage heart failure tend to have high mortality rates. With growing numbers of patients progressing into severe heart failure, the shortage of available donors is a growing concern, with less than 10% of patient…
View article: Multimodality Echocardiographic Imaging for a Novel Transcatheter Native Mitral Valve Replacement Procedure
Multimodality Echocardiographic Imaging for a Novel Transcatheter Native Mitral Valve Replacement Procedure Open
Transcatheter native mitral valve replacement (TMVR) is a novel procedure that has the potential to overcome some of the current limitations associated with the transcatheter edge-to-edge mitral valve (MV) repair technique. The aim of this…
View article: Three-dimensional printing in integrated multi-modality imaging approach for management of prosthetic valves infective endocarditis
Three-dimensional printing in integrated multi-modality imaging approach for management of prosthetic valves infective endocarditis Open
After heart failure, infectious endocarditis is the second leading cause of death in patients with prosthetic valves. Aortic pseudoaneurysms are a serious complication of infective endocarditis in mechanical or bioprosthetic aortic prosthe…
View article: Testosterone deficiency independently predicts mortality in women with HFrEF: insights from the T.O.S.CA. registry
Testosterone deficiency independently predicts mortality in women with HFrEF: insights from the T.O.S.CA. registry Open
Aims Testosterone deficiency (TD) is associated with increased morbidity and mortality in heart failure with reduced ejection fraction (HFrEF). However, data in women are scanty. The aim of this study was to investigate the prognostic impa…
View article: Leisure-Time Physical Activity Has a More Favourable Impact on Carotid Artery Stiffness Than Vigorous Physical Activity in Hypertensive Human Beings
Leisure-Time Physical Activity Has a More Favourable Impact on Carotid Artery Stiffness Than Vigorous Physical Activity in Hypertensive Human Beings Open
Aim. To assess the effect of leisure time versus vigorous long-term dynamic physical activity (PA) on carotid stiffness in normotensive versus hypertensive subjects. Methods. The study was conducted on 120 leisure-time exercisers and 120 c…
View article: Imaging in transcatheter native mitral valve replacement with Tendyne mitral valve system: Echocardiographic pathway for the interventional imager
Imaging in transcatheter native mitral valve replacement with Tendyne mitral valve system: Echocardiographic pathway for the interventional imager Open
The interaction between the implanter team and the imager team is critical to the success of transcatheter native mitral valve replacement (TMVR), a novel interventional procedure in the therapeutic arsenal for mitral regurgitation. This i…
View article: Correlation Between Different Parameters of Acute Myocardial Infarction and Obesity
Correlation Between Different Parameters of Acute Myocardial Infarction and Obesity Open
In this pilot study, the group with a high BMI had a statistically significant lower troponin level and higher mean heart rate. Such data need to be considered when assessing a patient's risk. In addition, obese persons with a MI had a hig…
View article: Blood pressure response to standing is a strong determinant of masked hypertension in young to middle-age individuals
Blood pressure response to standing is a strong determinant of masked hypertension in young to middle-age individuals Open
Objective: The pathophysiologic mechanisms of masked hypertension are still debated. The aim of this study was to investigate whether the blood pressure response to standing is a determinant of masked hypertension in young individuals. Des…
View article: Physiologic Range of Myocardial Mechano-Energetic Efficiency among Healthy Subjects: Impact of Gender and Age
Physiologic Range of Myocardial Mechano-Energetic Efficiency among Healthy Subjects: Impact of Gender and Age Open
Background: Myocardial mechano-energetic efficiency (MEE) is the capability of the left ventricle (LV) to convert the chemical energy obtained from the cardiac oxidative metabolism into mechanical work. The aim of present study was to esta…