Chuong D. Hoang
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View article: Identification of Cembrane Diterpenoids from <i>Sinularia</i> sp. That Reduce the Viability of Diffuse Pleural Mesothelioma Cell Lines
Identification of Cembrane Diterpenoids from <i>Sinularia</i> sp. That Reduce the Viability of Diffuse Pleural Mesothelioma Cell Lines Open
Diffuse pleural mesothelioma (DPM) is a rare but aggressive late-onset cancer. A high-throughput screen of a natural product fraction library identified fractions derived from an aqueous extract of Sinularia sp. soft coral that reduced the…
View article: Clinical factors associated with growth and neoantigen reactivity of tumor infiltrating lymphocytes from metastatic epithelial cancers
Clinical factors associated with growth and neoantigen reactivity of tumor infiltrating lymphocytes from metastatic epithelial cancers Open
Background Adoptive cell therapy with tumor infiltrating lymphocytes is FDA approved for metastatic melanoma. TIL from patients with melanoma and factors relating to growth and reactivity have been studied; however, this has not been explo…
View article: microRNA-497-5p-based screening identifies a novel synthetic lethal-type interaction via PKMYT1 and WEE1 in pleural mesothelioma
microRNA-497-5p-based screening identifies a novel synthetic lethal-type interaction via PKMYT1 and WEE1 in pleural mesothelioma Open
Diffuse pleural mesothelioma (DPM) is an incurable surface neoplasm governed by tumor suppressor losses with limited therapeutic options. Despite the advantages of leveraging the tumor suppressive activity of microRNA (miRNA/miR), clinical…
View article: Multimodal graph representation learning for website generation based on visual sketch
Multimodal graph representation learning for website generation based on visual sketch Open
The Design2Code problem, which involves converting digital designs into functional source code, is a significant challenge in software development due to its complexity and time-consuming nature. Traditional approaches often struggle with …
View article: Sesquiterpene Coumarin Ethers and Phenylpropanoids from the Roots of Ferula drudeana, the Putative Anatolian Ecotype of the Silphion Plant
Sesquiterpene Coumarin Ethers and Phenylpropanoids from the Roots of Ferula drudeana, the Putative Anatolian Ecotype of the Silphion Plant Open
Four new sesquiterpene coumarin ethers (1–4) and a new phenylpropanoid compound (5) were isolated from a hexane extract of the roots of Ferula drudeana, the putative Anatolian ecotype of the silphion plant, in addition to nineteen previous…
View article: Repression of ZNFX1 by LncRNA ZFAS1 mediates tobacco-induced pulmonary carcinogenesis
Repression of ZNFX1 by LncRNA ZFAS1 mediates tobacco-induced pulmonary carcinogenesis Open
Background Despite exhaustive research efforts, integrated genetic and epigenetic mechanisms contributing to tobacco-induced initiation and progression of lung cancers have yet to be fully elucidated. In particular, limited information is …
View article: Distill-C: Enhanced NL2SQL via Distilled Customization with LLMs
Distill-C: Enhanced NL2SQL via Distilled Customization with LLMs Open
The growing adoption of large language models (LLMs) in business applications has amplified interest in Natural Language to SQL (NL2SQL) solutions, in which there is competing demand for high performance and efficiency. Domain- and custome…
View article: Mastering the Craft of Data Synthesis for CodeLLMs
Mastering the Craft of Data Synthesis for CodeLLMs Open
Large language models (LLMs) have shown impressive performance in \emph{code} understanding and generation, making coding tasks a key focus for researchers due to their practical applications and value as a testbed for LLM evaluation. Data…
View article: Characterizing Lung Cancer in Li-Fraumeni Syndrome
Characterizing Lung Cancer in Li-Fraumeni Syndrome Open
This cohort study describes lung cancer incidence, diagnosis, and outcome in individuals with Li-Fraumeni syndrome.
View article: Resolving persistent air leaks associated with autosomal dominant hyper-IgE syndrome using one-way endobronchial valves: report of cases
Resolving persistent air leaks associated with autosomal dominant hyper-IgE syndrome using one-way endobronchial valves: report of cases Open
Our experience suggests that EBVs are successful in treating PAL in the setting of AD-HIES, which often manifests as highly complex scenarios. Hence, EBVs represent a valuable addition to the therapeutic armamentarium against recalcitrant …
View article: Kinetically Controlled Polyelectrolyte Complex Assembly of microRNA‐Peptide Nanoparticles toward Treating Mesothelioma
Kinetically Controlled Polyelectrolyte Complex Assembly of microRNA‐Peptide Nanoparticles toward Treating Mesothelioma Open
Broad size distributions and poor long‐term colloidal stability of microRNA‐carrying nanoparticles, especially those formed by polyelectrolyte complexation, represent major hurdles in realizing their clinical translation. Herein, peptide d…
View article: FIGURE 1 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts
FIGURE 1 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts Open
NCATS screening identifies TAK-243 as one of the most potent drugs against ACC cell lines. A, CU-ACC1, CU-ACC2, and NCI-H295R cell lines were screened with the NCATS MIPE v5.0 (MIPE 5.0) library of approved and investigational drugs (n = 2…
View article: FIGURE 6 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts
FIGURE 6 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts Open
NCATS screening for synergistic drug combinations with TAK-243 in the CU-ACC1 and NCI-H295R cell lines. One hundred and seven drugs were tested in combination with TAK-243. A, Overall result of the screen with drugs listed in ExcessHSA ord…
View article: FIGURE 7 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts
FIGURE 7 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts Open
Synergy between TAK-243 and Venetoclax in organoids generated from patient-derived xenograft (PDXO). A, Representative brightfield images of PDXOs (20x magnification, scale bar 50 µm). B, Phenotypic characteristics of PDXOs. Expression of …
View article: FIGURE 6 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts
FIGURE 6 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts Open
NCATS screening for synergistic drug combinations with TAK-243 in the CU-ACC1 and NCI-H295R cell lines. One hundred and seven drugs were tested in combination with TAK-243. A, Overall result of the screen with drugs listed in ExcessHSA ord…
View article: FIGURE 3 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts
FIGURE 3 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts Open
Activity of TAK-243 on ACC PDOs. Concentration–response curves and IC50 values of TAK-243 for ACC PDOs. The indicated concentrations of TAK-243 were administered to organoids derived from patients with ACC for 72 hours and cell viability w…
View article: FIGURE 2 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts
FIGURE 2 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts Open
Cytotoxicity of TAK-243 on ACC cell lines. A, Concentration–response curve and IC50 values of TAK-243 in ACC cell lines and SW-13. Cell viability after 72 hours under the indicated drug concentrations was measured by the CellTiter-Glo viab…
View article: Supplementary Table S2 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts
Supplementary Table S2 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts Open
Screening for drugs synergistic with TAK-243
View article: FIGURE 5 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts
FIGURE 5 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts Open
Synergy between TAK-243 and mitotane. A, Top: The indicated ACC cell lines were treated with TAK-243 with or without mitotane for 72 hours. Bottom: CI values were calculated and plotted. B, Enhanced induction of apoptosis by the TAK-243 + …
View article: Supplementary Figure S1 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts
Supplementary Figure S1 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts Open
Bortezomib concentration-response curve. Relationship between TAK243 activity and MDR1 and SLFN11 expression.