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View article: Diaphragm resuspension to titanium neo-ribs: A technique for chest-wall reconstruction involving the costal margin
Diaphragm resuspension to titanium neo-ribs: A technique for chest-wall reconstruction involving the costal margin Open
View article: Endoscopic mitral valve replacement surgery in patients with previous closed mitral commissurotomy: A case series report
Endoscopic mitral valve replacement surgery in patients with previous closed mitral commissurotomy: A case series report Open
Objective: To describe the diagnostic features, surgical techniques, and outcomes of endoscopic mitral valve replacement in patients with a history of closed commissurotomy. Methods: This is a case series study of patients with a history o…
View article: Early results of aortic root enlargement using y-incision technique (yang technique) in Hanoi Heart Hospital
Early results of aortic root enlargement using y-incision technique (yang technique) in Hanoi Heart Hospital Open
Background: Aortic root enlargement during aortic valve replacement (AVR) prevented patient-prosthesis mismatch (PPM) in patients with a small aortic annulus. The Y-incision technique, described by Yang B., was a simple and effective metho…
View article: Outcome of mini aortic valve replacement via right parasternal mini-thoracotomy in patients with challenging anatomy
Outcome of mini aortic valve replacement via right parasternal mini-thoracotomy in patients with challenging anatomy Open
Objective: To describe the diagnostic features, surgical techniques, and outcomes of minimally invasive aortic valve replacement via right parasternal thoracotomy in patients with unfavorable anatomy. Methods: This is a retrospective descr…
View article: Midterm results of totally endoscopic mitral valve replacement via right minithoracotomy at Hanoi Heart Hospital
Midterm results of totally endoscopic mitral valve replacement via right minithoracotomy at Hanoi Heart Hospital Open
This was a cross- sectional study included 121 patients with mean age of 57 ± 9.2 years (35 - 75), 80.2% of patients was women. All patients had heart failure classified by NYHA as moderate to severe, with 66.9% falling into NYHA classes 3…
View article: Report of a successful emergency endovascular abdominal aneurysm repair in a 101 years-old patient
Report of a successful emergency endovascular abdominal aneurysm repair in a 101 years-old patient Open
We report successful endovascular treatment case of a juxta - renal abdominal aortic aneurysm (AAA) in a 101-year-old male. This is also one of the oldest cases reported in the literature. Through this case, we share our experience in pre-…
View article: Effective gene therapy for metachromatic leukodystrophy achieved with minimal lentiviral genomic integrations
Effective gene therapy for metachromatic leukodystrophy achieved with minimal lentiviral genomic integrations Open
Metachromatic leukodystrophy (MLD) is a fatal lysosomal storage disease characterized by the deficient enzymatic activity of arylsulfatase A (ARSA). Combined autologous hematopoietic stem cell transplantion (HSCT) with lentiviral (LV)-base…
View article: Extravascular Images of a Penetrating Aortic Ulcer Discovered During Robotic Segmentectomy
Extravascular Images of a Penetrating Aortic Ulcer Discovered During Robotic Segmentectomy Open
None.
View article: Bone marrow transplantation increases sulfatase activity in somatic tissues in a multiple sulfatase deficiency mouse model
Bone marrow transplantation increases sulfatase activity in somatic tissues in a multiple sulfatase deficiency mouse model Open
Our results indicate that HSCT could be a suitable approach to treat MSD-pathology affecting peripheral organs, however that benefit to CNS pathology might be limited.
View article: 8194 Extramedullary Hematopoiesis Involving Bilateral Adrenal Glands In A Patient With Sickle Cell Anemia
8194 Extramedullary Hematopoiesis Involving Bilateral Adrenal Glands In A Patient With Sickle Cell Anemia Open
Disclosure: V.T. Pham: None. L.N. Sendos: None. Title: Extramedullary hematopoiesis involving bilateral adrenal glands in a patient with sickle cell anemia Background: Extramedullary hematopoiesis refers to blood cell production occurring …
View article: Hematopoietic stem cell gene therapy improves outcomes in a clinically relevant mouse model of multiple sulfatase deficiency
Hematopoietic stem cell gene therapy improves outcomes in a clinically relevant mouse model of multiple sulfatase deficiency Open
Multiple sulfatase deficiency (MSD) is a severe, lysosomal storage disorder caused by pathogenic variants in the gene SUMF1, encoding the sulfatase modifying factor formylglycine-generating enzyme. Patients with MSD exhibit functional defi…
View article: Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations
Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations Open
Metachromatic leukodystrophy (MLD) is a fatal lysosomal storage disease (LSD) characterized by the deficient enzymatic activity of arylsulfatase A (ARSA). Combined autologous hematopoietic stem cell transplant (HSCT) with lentiviral (LV) b…
View article: Hematopoietic stem cell gene therapy improves outcomes in a clinically relevant mouse model of Multiple Sulfatase Deficiency
Hematopoietic stem cell gene therapy improves outcomes in a clinically relevant mouse model of Multiple Sulfatase Deficiency Open
Multiple sulfatase deficiency (MSD) is a severe, lysosomal storage disorder caused by pathogenic variants in the gene SUMF1, encoding the sulfatase modifying factor formylglycine-generating enzyme. Patients with MSD exhibit functional defi…
View article: Chronic GLP1 therapy reduces postprandial IL6 in obese humans with prediabetes
Chronic GLP1 therapy reduces postprandial IL6 in obese humans with prediabetes Open
Single-dose glucagon-like peptide 1 (GLP1) therapy increases postprandial plasma IL6 levels in prediabetic, obese humans. GLP1-IL6 interactions underly multiple antidiabetic effects, but these may differ after acute versus chronic therapy.…
View article: A novel iPSC model reveals selective vulnerability of neurons in multiple sulfatase deficiency
A novel iPSC model reveals selective vulnerability of neurons in multiple sulfatase deficiency Open
Multiple sulfatase deficiency (MSD) is an ultra-rare, inherited lysosomal storage disease caused by mutations in the gene sulfatase modifying factor 1 (SUMF1). MSD is characterized by the functional deficiency of all sulfatase enzymes, lea…
View article: Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke
Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke Open
Stroke is a leading cause of mortality and morbidity with a paucity of effective pharmacological treatments. We have previously identified insulin-regulated aminopeptidase (IRAP) as a potential target for the development of a new class of …
View article: Biochemical signatures of disease severity in multiple sulfatase deficiency
Biochemical signatures of disease severity in multiple sulfatase deficiency Open
Sulfatases catalyze essential cellular reactions, including degradation of glycosaminoglycans (GAGs). All sulfatases are post‐translationally activated by the formylglycine generating enzyme (FGE) which is deficient in multiple sulfatase d…
View article: A novel iPSC model reveals selective vulnerability of neurons in Multiple Sulfatase Deficiency
A novel iPSC model reveals selective vulnerability of neurons in Multiple Sulfatase Deficiency Open
Multiple sulfatase deficiency (MSD) is an ultra-rare, inherited lysosomal storage disease caused by mutations in the gene sulfatase modifying factor 1 ( SUMF1 ). MSD is characterized by the functional deficiency of all sulfatase enzymes, l…
View article: Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR Open
View article: Role of Conserved Tyrosine Lid Residues in the Activation of the M2 Muscarinic Acetylcholine Receptor
Role of Conserved Tyrosine Lid Residues in the Activation of the M2 Muscarinic Acetylcholine Receptor Open
The development of subtype selective small molecule drugs for the muscarinic acetylcholine receptor (mAChR) family has been challenging. The design of more selective ligands can be improved by understanding the structure and function of ke…
View article: Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics Open
Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular-level understanding of the general principles that govern the myriad pharmacological effects exert…
View article: Author response: Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Author response: Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstr…
View article: Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs
Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs Open
View article: Structural basis of efficacy-driven ligand selectivity at GPCRs
Structural basis of efficacy-driven ligand selectivity at GPCRs Open
View article: Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics Open
Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular level understanding of the general principals that govern the myriad pharmacological effects exert…
View article: The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the δ<i>-</i>Opioid Receptor
The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the δ<i>-</i>Opioid Receptor Open
Chronic pain and depression are both widely prevalent comorbid medical conditions. While efficient, μ-opioid receptor-based medications are associated with life-threatening side effects, including respiratory depression, dependence, and ad…
View article: Structure–activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4
Structure–activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4 Open
View article: Correction to: Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting
Correction to: Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting Open
View article: Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting
Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting Open
View article: Structural and Dynamic Mechanisms of Allostery at the M4 Muscarinic Acetylcholine Receptor
Structural and Dynamic Mechanisms of Allostery at the M4 Muscarinic Acetylcholine Receptor Open