Wayne C. Levy
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View article: Cardiac Magnetic Resonance, Electromechanical Activation, Kidney Function, and Natriuretic Peptides in Cardiac Resynchronization Therapy Upgrades
Cardiac Magnetic Resonance, Electromechanical Activation, Kidney Function, and Natriuretic Peptides in Cardiac Resynchronization Therapy Upgrades Open
As the mechanism for worse prognosis after cardiac resynchronization therapy (CRT) upgrades in heart failure patients with RVP dependence (RVP-HF) has clinical implications for patient selection and CRT implementation approaches, this stud…
Predicting 1-Year Mortality in Outpatients With Heart Failure With Reduced Left Ventricular Ejection Fraction: Do Empiric Models Outperform Physician Intuitive Estimates? A Multicenter Cohort Study Open
BACKGROUND: Many studies have demonstrated that physicians often err in estimating patient prognosis. No studies have directly compared physician to model predictive performance in heart failure (HF). We aimed to compare the accuracy of ph…
Beta‐blocker use and mortality among patients with systolic heart failure and pacemaker rhythm Open
Aims Beta‐blockers are proven to improve survival among patients with heart failure with reduced ejection fraction. Their efficacy in patients with heart failure with reduced ejection fraction and pacemaker devices has not been demonstrate…
Sudden cardiac death in heart failure. A 20 years perspective from a Mediterranean cohort Open
Background Although sudden cardiac death (SCD) has progressively decreased in the last decade, it remains an important cause of death in patients with heart failure (HF). Differences based on clinical management and regional characteristic…
Design of the remedē System Therapy (rēST) study: A prospective non-randomized post-market study collecting clinical data on safety and effectiveness of the remedē system for the treatment of central sleep apnea Open
This will be the largest prospective study evaluating long-term safety and effectiveness of transvenous phrenic nerve stimulation for the treatment of moderate to severe CSA in adult patients.
Survival Probability and Survival Benefit Associated With Primary Prevention Implantable Cardioverter‐Defibrillator Generator Changes Open
Background As patients derive variable benefit from generator changes (GCs) of implantable cardioverter‐defibrillators (ICDs) with an original primary prevention (PP) indication, better predictors of outcomes are needed. Methods and Result…
View article: Predictors of primary prevention implantable cardioverter‐defibrillator use in heart failure with reduced ejection fraction: impact of the predicted risk of sudden cardiac death and all‐cause mortality
Predictors of primary prevention implantable cardioverter‐defibrillator use in heart failure with reduced ejection fraction: impact of the predicted risk of sudden cardiac death and all‐cause mortality Open
Aims Use of implantable cardioverter‐defibrillators (ICD) for primary prevention of sudden cardiac death (SCD) in heart failure with reduced ejection fraction (HFrEF) is limited. We aimed to investigate barriers to ICD use in HFrEF while c…
Mortality Risk Prediction Dynamics After Heart Failure Treatment Optimization: Repeat Risk Assessment Using Online Risk Calculators Open
Objectives Heart failure (HF) management has significantly improved over the past two decades, leading to better survival. This study aimed to assess changes in predicted mortality risk after 12 months of management in a multidisciplinary …
Lack of Association Between Neurohormonal Blockade and Survival in Transthyretin Cardiac Amyloidosis Open
Background Despite the belief that heart failure therapies are not effective in transthyretin cardiac amyloidosis, data are limited. We tested the association of neurohormonal blockade use with survival. Methods and Results A total of 309 …
Head‐to‐head comparison of contemporary heart failure risk scores Open
Aims Several heart failure (HF) web‐based risk scores are currently used in clinical practice. Currently, we lack head‐to‐head comparison of the accuracy of risk scores. This study aimed to assess correlation and mortality prediction perfo…
Sudden cardiac death after acute decompensation in heart failure patients: implications of discharge haemoglobin levels Open
Aims Heart failure (HF) patients have a high risk of mortality due to sudden cardiac death (SCD) and non‐SCD, including pump failure death (PFD). Anaemia predicts more severe symptomatic burden and higher morbidity, as noted by markedly in…
Treating symptoms and reversing remodelling: clinical and echocardiographic <span>1‐year</span> outcomes with percutaneous mitral annuloplasty for mild to moderate secondary mitral regurgitation Open
Aims To determine the effects of percutaneous mitral annuloplasty on symptoms, walk distance and left ventricular (LV) structure and function in patients with mild or moderate secondary mitral regurgitation (SMR). Methods and results This …
Cost‐effectiveness of left ventricular assist devices as destination therapy in the United Kingdom Open
Aims Continuous‐flow left ventricular assist devices (LVADs) as destination therapy (DT) are a recommended treatment by National Institute for Health and Care Excellence England for end‐stage heart failure patients ineligible for cardiac t…
The association between heart failure and incident cancer in women: an analysis of the Women's Health Initiative Open
Aims There is conflicting evidence whether heart failure (HF) is a risk factor for incident cancer. Despite population‐based cohorts demonstrating this association, an analysis of the Physician's Health Study found no association in a coho…
Looking forward and backward for sudden death risk: competing risk is everywhere Open
This article refers to ‘Dynamic changes in cardiovascular and systemic parameters prior to sudden cardiac death in heart failure with reduced ejection fraction: a PARADIGM-HF analysis’ by L.E. Rohde et al., published in this issue on pages…
Functional outcomes with Carillon device over 1 year in patients with functional mitral regurgitation of Grades 2+ to 4+: results from the REDUCE‐FMR trial Open
Aims The objective of this study was to compare functional outcomes through 1 year in patients with core‐lab verified moderate to severe (Grades 2+ to 4+) functional mitral regurgitation (FMR) treated with the Carillon device or control in…
View article: Accuracy of Doppler blood pressure measurement in HeartMate 3 ventricular assist device patients
Accuracy of Doppler blood pressure measurement in HeartMate 3 ventricular assist device patients Open
Aims Optimal blood pressure (BP) control is imperative to reduce complications, especially strokes, in continuous flow ventricular assist device (VAD) patients. Doppler BP has been shown to be an accurate and reliable non‐invasive BP measu…
Cost-Effectiveness of a Small Intrapericardial Centrifugal Left Ventricular Assist Device Open
There is limited data on the cost-effectiveness of continuous-flow left ventricular assist devices (LVAD) in the United States particularly for the bridge-to-transplant indication. Our objective is to study the cost-effectiveness of a smal…
Cost-Effectiveness of Thoracotomy Approach for the Implantation of a Centrifugal Left Ventricular Assist Device Open
This study reports the first analysis regarding cost-effectiveness of left ventricular assist device (LVAD) implantation via thoracotomy. Cost-effectiveness of LVADs implanted via the traditional surgical approach of sternotomy has been im…
View article: Variant Interpretation for Dilated Cardiomyopathy
Variant Interpretation for Dilated Cardiomyopathy Open
Background: The hypothesis of the Dilated Cardiomyopathy Precision Medicine Study is that most dilated cardiomyopathy has a genetic basis. The study returns results to probands and, when indicated, to relatives. While both the American Col…
Sudden cardiac death after myocardial infarction Open
This article refers to ‘Predictors of sudden cardiac death in high-risk patients following a myocardial infarction’ by K.F. Docherty et al., published in this issue on pages 848–855. Sudden cardiac death (SCD) accounts for 15–20% of global…
View article: Accuracy of <scp>Doppler</scp> blood pressure measurement in continuous‐flow left ventricular assist device patients
Accuracy of <span>Doppler</span> blood pressure measurement in continuous‐flow left ventricular assist device patients Open
Aims Accurate blood pressure (BP) measurement in continuous‐flow ventricular assist device (CF‐VAD) patients is imperative to reduce stroke risk. This study assesses the accuracy of the Doppler opening pressure method compared with the gol…