Weiam Hussein
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View article: Antibacterial Potential of Rumex Vesicarius: A Phytochemical Perspective
Antibacterial Potential of Rumex Vesicarius: A Phytochemical Perspective Open
Known as a rich source of physiologically active metabolites, Rumex vesicarius has had multiple uses in Arabian traditional medicine. Present study focused on phytochemical profiling and antimicrobial effects of methanolic extracts of R. v…
View article: Antidepressants to Prevent the Progression of Depressive Dementia to Alzheimer’s Disease: Evaluating the Degree of Knowledge about this Topic
Antidepressants to Prevent the Progression of Depressive Dementia to Alzheimer’s Disease: Evaluating the Degree of Knowledge about this Topic Open
A BSTRACT Background: Depressive dementia is a major modifiable risk factor for Alzheimer’s disease (AD), a complex and multifactorial condition. Although depression has been linked to dementia, the relationship remains incompletely unders…
View article: Biological Activities and Phytochemical Screening of Thuja occidentalis Extracts with In Silico Approaches
Biological Activities and Phytochemical Screening of Thuja occidentalis Extracts with In Silico Approaches Open
The evergreen coniferous tree Thuja occidentalis is a member of the Cupressaceae family. This study included biological, cytotoxic, and in silico docking analyses in addition to a phytochemical composition analysis of the plant leaves and …
View article: Novel Insights in the Hypertension Treatment & Type 2 Diabetics Induced by Angiotensin Receptor Blockers: MD Simulation Studies & Molecular Docking of Some Promising Natural Therapies
Novel Insights in the Hypertension Treatment & Type 2 Diabetics Induced by Angiotensin Receptor Blockers: MD Simulation Studies & Molecular Docking of Some Promising Natural Therapies Open
Angiotensin receptor blockers (ARBs) are commonly used to treat hypertension that target the hormonal system (renin-angiotensin system (RAS)), which regulates various physiological functions in the body. ARBs work by blocking the binding o…
View article: A Questionnaire-Based Study on the Use of Weight-Loss Medicines and Herbal Mixtures among Pharmacy Students in the Hail Region
A Questionnaire-Based Study on the Use of Weight-Loss Medicines and Herbal Mixtures among Pharmacy Students in the Hail Region Open
Objectives: The obesity epidemic continues to grow at an alarming rate because the lifestyle we live plays a big role in the continuation and exacerbation of this problem. The use of medicines and herbs has become widespread, especially am…
View article: CCDC 2295818: Experimental Crystal Structure Determination
CCDC 2295818: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Correlation Between Structure and New Anti-cancer Activity of Some Antioxidants Following Chemical Structure Modification Does The Evidence Support This Correlation
Correlation Between Structure and New Anti-cancer Activity of Some Antioxidants Following Chemical Structure Modification Does The Evidence Support This Correlation Open
In medicinal chemistry, the link between structure and activity is essential. We are seeking to relate chemical structure and reactivity to medicinal properties, which has gained popularity recently. In this study, scaffolds from three ant…
View article: Chemical Composition, Antibacterial Activity and In Vitro Anticancer Evaluation of Ochradenus baccatus Methanolic Extract
Chemical Composition, Antibacterial Activity and In Vitro Anticancer Evaluation of Ochradenus baccatus Methanolic Extract Open
Background and Objectives: Ochradenus baccatus belongs to the family Resedaceae. It is widely spread in Saudi Arabia and other countries in Southwest Asia. O. baccatus is extensively used in traditional medicine as an anti-inflammatory and…
View article: Metformin Therapy and Breast Cancer Incidence in the Ha’il Region
Metformin Therapy and Breast Cancer Incidence in the Ha’il Region Open
Background: Metformin is a drug used to treat patients with type 2 diabetes, especially those who suffer from obesity. It is also used in the treatment of women with polycystic ovary syndrome (PCOS). This disease is related to insulin resi…
View article: Metformin Therapy and Breast Cancer Incidence in the Hail Region
Metformin Therapy and Breast Cancer Incidence in the Hail Region Open
Background: Metformin is a drug used to treat patients with type 2 diabetes, especially those who suffer from obesity. It is also used in the treatment of women with polycystic ovary syndrome (PCOS). This disease has been shown to be relat…
View article: Discovery of A Novel Synthetic Thiazole-benzimidazole Conjugate that Acts as a Potent Pancreatic Lipase Inhibitor using in silico and in vitro Approaches
Discovery of A Novel Synthetic Thiazole-benzimidazole Conjugate that Acts as a Potent Pancreatic Lipase Inhibitor using in silico and in vitro Approaches Open
Aim/ Background: Pancreatic lipase (PL) inhibition has been suggested to be an effective method for obesity management. In this study, 10 novel thiazole-benzimidazole conjugates were designed. Materials and Methods: Conjugates were initial…
View article: Study of electrochemical behavior of two chemically similar acridines: Tacrine and 9-aminoacridine on hanging mercury drop electrode
Study of electrochemical behavior of two chemically similar acridines: Tacrine and 9-aminoacridine on hanging mercury drop electrode Open
The electrochemical behavior of two chemically related acridine compounds: tacrine (TAC) and 9-aminoacridine (9-AA) was investigated on a hanging mercury drop electrode (HDME). The electrochemical study was carried out by using Osteryoung …
View article: The Effect of Patient Education Interventions on Asthma Management in Hail Region
The Effect of Patient Education Interventions on Asthma Management in Hail Region Open
The rising importance of educating asthma patients about their medication and devices and how to use them and the impact of this knowledge on controlling the disease and improving the quality of life has attracted great interest from resea…
View article: In vitro antimicrobial, anticancer, and apoptosis-inducing effects of the methanolic extract of Launaea mucronata
In vitro antimicrobial, anticancer, and apoptosis-inducing effects of the methanolic extract of Launaea mucronata Open
Traditional medicine is widely used in the treatment and management of various ailments due to its low toxicity, low number of side effects and low cost. Many components of common fruits and vegetables play crucial roles as chemopreventive…
View article: The Connection Between Depression And Chronic Pain. A Cross-Sectional Study For Individuals With Chronic Pain In Hail Region
The Connection Between Depression And Chronic Pain. A Cross-Sectional Study For Individuals With Chronic Pain In Hail Region Open
Chronic pain is a physical disorder and a critical factor in determining depression. Their synchronicity tends to worsen the risk of both disorders. The research to date has found little information about the relationship between them. Thi…
View article: Prospective Cross-Sectional Study of the Uses of Non-prescription Analgesics among Hail Residents
Prospective Cross-Sectional Study of the Uses of Non-prescription Analgesics among Hail Residents Open
The aim of this paper was to describe the general status of the use of non-prescription analgesics (NPA) among the residents of Hail city to ensure the safe use of non-prescription analgesics. Â One hundred participants with different dise…
View article: Synthetic Advances against Coronaviruses: A Short Review of the Recent Literature on Newly Synthetized Derivatives and Recently Developed Strategies
Synthetic Advances against Coronaviruses: A Short Review of the Recent Literature on Newly Synthetized Derivatives and Recently Developed Strategies Open
The coronavirus pandemic is a modern social emergency and the biggest global challenge since the Second World War. Since the pandemic began in China at the end of 2019, the disease spread to every landmass except Antarctica. The effect of …
View article: Between old drugs & New approaches for acute migraine: Utilization pattern of migraine medications on patients in private & Public care hospitals in Hail City
Between old drugs & New approaches for acute migraine: Utilization pattern of migraine medications on patients in private & Public care hospitals in Hail City Open
Migraines are a common cause of permanent patient visits to public and private clinics. The symptoms that drive patients to clinics are often intolerable from pain anomaly and medications do not give any quick effect to reduce pain. This s…
View article: Synthesis and Evaluation of <i>N</i>-[1-(((3,4-Diphenylthiazol-2(3<i>H</i>)-ylidene)amino)methyl)cyclopentyl]acetamide Derivatives for the Treatment of Diseases Belonging to MAOs
Synthesis and Evaluation of <i>N</i>-[1-(((3,4-Diphenylthiazol-2(3<i>H</i>)-ylidene)amino)methyl)cyclopentyl]acetamide Derivatives for the Treatment of Diseases Belonging to MAOs Open
A series of N -[1-(((3,4-diphenylthiazol-2(3 H )-ylidene)amino)methyl)cyclopentyl]acetamide derivatives ( 4a-4i ) were synthesized in good yield and assayed for their inhibitory potency against monoamine oxidase (MAO) isoforms. Structures …
View article: Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer’s Disease
Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the weakening of the ch…
View article: Synthesis of new thiazole and thiazolyl derivatives of medicinal significant-a short review
Synthesis of new thiazole and thiazolyl derivatives of medicinal significant-a short review Open
In the field of therapeutic science, thiazoles are of extraordinary importance, because of their potent and significant biological activities.Likewise thiazole and their derivatives are found in various powerful naturally and biologically …
View article: Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors
Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors Open
A new series of N-pyridyl-hydrazone derivatives was synthesized by using a simple and efficient method. The final compounds obtained were screened for their inhibitory potency against monoamine oxidase (MAO) A and B. The newly synthesized …