Andrew W. Murray
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View article: The B-type cyclin Clb4 prevents meiosis I sister centromere separation in budding yeast
The B-type cyclin Clb4 prevents meiosis I sister centromere separation in budding yeast Open
In meiosis, one round of DNA replication followed by two rounds of chromosome segregation halves the ploidy of the original cell. Accurate chromosome segregation in meiosis I depends on recombination between homologous chromosomes. Sister …
View article: A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A
A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A Open
View article: Cell integrity limits ploidy in budding yeast
Cell integrity limits ploidy in budding yeast Open
Evidence suggests that increases in ploidy have occurred frequently in the evolutionary history of organisms and can serve adaptive functions to specialized somatic cells in multicellular organisms. However, the sudden multiplication of al…
View article: Tree-of-Quote Prompting Improves Factuality and Attribution in Multi-Hop and Medical Reasoning
Tree-of-Quote Prompting Improves Factuality and Attribution in Multi-Hop and Medical Reasoning Open
View article: The B-type cyclin Clb4 prevents meiosis I sister centromere separation in budding yeast
The B-type cyclin Clb4 prevents meiosis I sister centromere separation in budding yeast Open
In meiosis, one round of DNA replication followed by two rounds of chromosome segregation halves the ploidy of the original cell. Accurate chromosome segregation in meiosis I depends on recombination between homologous chromosomes. Sister …
View article: A dynamic network model predicts the phenotypes of multicellular clusters from cellular properties
A dynamic network model predicts the phenotypes of multicellular clusters from cellular properties Open
View article: Alternating selection for dispersal and multicellularity favors regulated life cycles
Alternating selection for dispersal and multicellularity favors regulated life cycles Open
View article: A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A
A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A Open
Eukaryotic translation elongation factor 1A (eEF1A) is a highly abundant, multi-domain GTPase. Post-translational steps essential for eEF1A biogenesis are carried out by bespoke chaperones but co-translational mechanisms tailored to eEF1A …
View article: Multicellular growth as a dynamic network of cells
Multicellular growth as a dynamic network of cells Open
Summary Cell division without cell separation produces multicellular clusters in budding yeast. Two fundamental characteristics of these clusters are their size (the number of cells per cluster) and cellular composition: the fractions of c…
View article: Extending the reach of homology by using successive computational filters to find yeast pheromone genes
Extending the reach of homology by using successive computational filters to find yeast pheromone genes Open
View article: Correction: Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress
Correction: Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress Open
[This corrects the article DOI: 10.1371/journal.pgen.1009875.].
View article: Alternating selection for dispersal and multicellularity favors regulated life cycles
Alternating selection for dispersal and multicellularity favors regulated life cycles Open
View article: Smar2C2: A Simple and Efficient Protocol for the Identification of Transcription Start Sites
Smar2C2: A Simple and Efficient Protocol for the Identification of Transcription Start Sites Open
Promoters and the noncoding sequences that drive their function are fundamental aspects of genes that are critical to their regulation. The transcription preinitiation complex binds and assembles on promoters where it facilitates transcrip…
View article: Zinc-finger protein Zpr1 is a bespoke chaperone essential for eEF1A biogenesis
Zinc-finger protein Zpr1 is a bespoke chaperone essential for eEF1A biogenesis Open
View article: Alternating selection for dispersal and multicellularity favors regulated life cycles
Alternating selection for dispersal and multicellularity favors regulated life cycles Open
Summary The evolution of complex multicellularity opened paths to increased morphological diversity and organizational novelty. This transition involved three processes: cells remained attached to one another to form groups, cells within t…
View article: Simple and accurate transcriptional start site identification using Smar2C2 and examination of conserved promoter features
Simple and accurate transcriptional start site identification using Smar2C2 and examination of conserved promoter features Open
SUMMARY The precise and accurate identification and quantification of transcriptional start sites (TSSs) is key to understanding the control of transcription. The core promoter consists of the TSS and proximal non‐coding sequences, which a…
View article: Mixing genome annotation methods in a comparative analysis inflates the apparent number of lineage-specific genes
Mixing genome annotation methods in a comparative analysis inflates the apparent number of lineage-specific genes Open
Comparisons of genomes of different species are used to identify lineage-specific genes, those genes that appear unique to one species or clade. Lineage-specific genes are often thought to represent genetic novelty that underlies unique ad…
View article: Mixing genome annotation methods in a comparative analysis inflates the apparent number of lineage-specific genes
Mixing genome annotation methods in a comparative analysis inflates the apparent number of lineage-specific genes Open
Summary Comparisons of genomes of different species are used to identify lineage-specific genes, those genes that appear unique to one species or clade. Lineage-specific genes are often thought to represent genetic novelty that underlies u…
View article: Mixing Genome Annotation Methods in a Comparative Analysis Inflates the Apparent Number of Lineage-Specific Genes
Mixing Genome Annotation Methods in a Comparative Analysis Inflates the Apparent Number of Lineage-Specific Genes Open
View article: Antagonism between killer yeast strains as an experimental model for biological nucleation dynamics
Antagonism between killer yeast strains as an experimental model for biological nucleation dynamics Open
Antagonistic interactions are widespread in the microbial world and affect microbial evolutionary dynamics. Natural microbial communities often display spatial structure, which affects biological interactions, but much of what we know abou…
View article: Rocket yeast
Rocket yeast Open
This paper is associated with a video winner of a 2020 American Physical Society's Division of Fluid Dynamics (DFD) Milton van Dyke Award for work presented at the DFD Gallery of Fluid Motion. The original video is available online at the …
View article: Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress
Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress Open
In haploid budding yeast, evolutionary adaptation to constitutive DNA replication stress alters three genome maintenance modules: DNA replication, the DNA damage checkpoint, and sister chromatid cohesion. We asked how these trajectories de…
View article: Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress
Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress Open
In haploid budding yeast, evolutionary adaptation to constitutive DNA replication stress alters three genome maintenance modules: DNA replication, the DNA damage checkpoint, and sister chromatid cohesion. We asked how these trajectories de…
View article: 278 Using infographics and video to prevent injuries and illnesses in athletics
278 Using infographics and video to prevent injuries and illnesses in athletics Open
Background Injuries and illnesses represent a health problem affecting athletics athletes' training and performance. Recently, research on injury and illness epidemiology and risk factors have provided some insights to help implement preve…
View article: Beyond the reach of homology: successive computational filters find yeast pheromone genes
Beyond the reach of homology: successive computational filters find yeast pheromone genes Open
The mating of fungi depends on pheromones that mediate communication between two mating types. Most species use short peptides as pheromones, which are either unmodified (e.g., α-factor in Saccharomyces cerevisiae ) or C-terminally farnesy…
View article: Author response: Antagonism between killer yeast strains as an experimental model for biological nucleation dynamics
Author response: Antagonism between killer yeast strains as an experimental model for biological nucleation dynamics Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Antagonistic interactions are widespread i…
View article: Stimulation of p38 Phosphorylation and Activity by Arachidonic Acid in HeLa Cells, HL60 Promyelocytic Leukemic Cells, and Human Neutrophils: EVIDENCE FOR CELL TYPE-SPECIFIC ACTIVATION OF MITOGEN-ACTIVATED PROTEIN KINASES
Stimulation of p38 Phosphorylation and Activity by Arachidonic Acid in HeLa Cells, HL60 Promyelocytic Leukemic Cells, and Human Neutrophils: EVIDENCE FOR CELL TYPE-SPECIFIC ACTIVATION OF MITOGEN-ACTIVATED PROTEIN KINASES Open
Although it is well appreciated that arachidonic acid, a second messenger molecule that is released by ligand-stimulated phospholipase A2, stimulates a wide range of cell types, the mechanisms that mediate the actions of arachidonic acid a…
View article: Localization of Mad2 to Kinetochores Depends on Microtubule Attachment, Not Tension
Localization of Mad2 to Kinetochores Depends on Microtubule Attachment, Not Tension Open
A single unattached kinetochore can delay anaphase onset in mitotic tissue culture cells (Rieder, C.L., A. Schultz, R. Cole, G. Sluder. 1994. J. Cell Biol. 127:1301–1310). Kinetochores in vertebrate cells contain multiple binding sites, an…
View article: Modeling the impact of single-cell stochasticity and size control on the population growth rate in asymmetrically dividing cells
Modeling the impact of single-cell stochasticity and size control on the population growth rate in asymmetrically dividing cells Open
Microbial populations show striking diversity in cell growth morphology and lifecycle; however, our understanding of how these factors influence the growth rate of cell populations remains limited. We use theory and simulations to predict …
View article: Rapid toxin sequestration modifies poison frog physiology
Rapid toxin sequestration modifies poison frog physiology Open
Poison frogs sequester chemical defenses from their diet of leaf litter arthropods for defense against predation. Little is known about the physiological adaptations that confer this unusual bioaccumulation ability. We conducted an alkaloi…