Frank W. Booth
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View article: Temporal dynamics of the multi-omic response to endurance exercise training
Temporal dynamics of the multi-omic response to endurance exercise training Open
View article: Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions
Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions Open
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have been extensively researched since the landmark report by Morpurgo (1897) of “work-induced hypertrophy” in dogs that were treadmill trained. Much of the prec…
View article: Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function
Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function Open
Physical inactivity is the 4th leading cause of death globally and has been shown to significantly increase the risk for developing Alzheimer’s Disease (AD). Recent work has demonstrated that exercise prior to breeding produces heritable b…
View article: Acute Wheel-Running Increases Markers of Stress and Aversion-Related Signaling in the Basolateral Amygdala of Male Rats
Acute Wheel-Running Increases Markers of Stress and Aversion-Related Signaling in the Basolateral Amygdala of Male Rats Open
Physical activity (PA) is a non-invasive, cost-effective means of reducing chronic disease. Most US citizens fail to meet PA guidelines, and individuals experiencing chronic stress are less likely to be physically active. To better underst…
View article: Proceedings from the Albert Charitable Trust Inaugural Workshop on ‘Understanding the Acute Effects of Exercise on the Brain’
Proceedings from the Albert Charitable Trust Inaugural Workshop on ‘Understanding the Acute Effects of Exercise on the Brain’ Open
An inaugural workshop supported by “The Leo and Anne Albert Charitable Trust,” was held October 4–7, 2019 in Scottsdale, Arizona, to focus on the effects of exercise on the brain and to discuss how physical activity may prevent or delay th…
View article: Temporal dynamics of the multi-omic response to endurance exercise training across tissues
Temporal dynamics of the multi-omic response to endurance exercise training across tissues Open
Regular exercise promotes whole-body health and prevents disease, yet the underlying molecular mechanisms throughout a whole organism are incompletely understood. Here, the Molecular Transducers of Physical Activity Consortium (MoTrPAC) pr…
View article: Hepatocyte‐specific eNOS deletion impairs exercise‐induced adaptations in hepatic mitochondrial function and autophagy
Hepatocyte‐specific eNOS deletion impairs exercise‐induced adaptations in hepatic mitochondrial function and autophagy Open
Objective Endothelial nitric oxide synthase (eNOS) is a potential mediator of exercise‐induced hepatic mitochondrial adaptations. Methods Here, male and female hepatocyte‐specific eNOS knockout (eNOS hep−/− ) and intact hepatic eNOS (eNOS …
View article: Creatine Supplementation Upregulates mTORC1 Signaling and Markers of Synaptic Plasticity in the Dentate Gyrus While Ameliorating LPS-Induced Cognitive Impairment in Female Rats
Creatine Supplementation Upregulates mTORC1 Signaling and Markers of Synaptic Plasticity in the Dentate Gyrus While Ameliorating LPS-Induced Cognitive Impairment in Female Rats Open
Mild cognitive impairment (MCI) designates the boundary area between cognitive function in natural aging and dementia, and this is viewed as a therapeutic window to prevent the occurrence of dementia. The current study investigated the neu…
View article: A tribute to Charles M. “Tip” Tipton (1927–2021)
A tribute to Charles M. “Tip” Tipton (1927–2021) Open
View article: Five months of voluntary wheel running downregulates skeletal muscle LINE-1 gene expression in rats
Five months of voluntary wheel running downregulates skeletal muscle LINE-1 gene expression in rats Open
Transposable elements (TEs) are mobile DNA and constitute approximately half of the human genome. LINE-1 (L1) is the only active autonomous TE in the mammalian genome and has been implicated in a number of diseases as well as aging. We hav…
View article: Resistance-exercise training ameliorates LPS-induced cognitive impairment concurrent with molecular signaling changes in the rat dentate gyrus
Resistance-exercise training ameliorates LPS-induced cognitive impairment concurrent with molecular signaling changes in the rat dentate gyrus Open
Effective treatments preventing brain neuroinflammatory diseases are lacking. Resistance-exercise training (RT) ameliorates mild cognitive impairment (MCI), a forerunner to neuroinflammatory diseases. However, few studies have addressed th…
View article: Rats Selectively Bred for High Voluntary Physical Activity Behavior are Not Protected from the Deleterious Metabolic Effects of a Western Diet When Sedentary
Rats Selectively Bred for High Voluntary Physical Activity Behavior are Not Protected from the Deleterious Metabolic Effects of a Western Diet When Sedentary Open
View article: PO-131 Impact of short-term inhibition of PKA in Nucleus Accumbens on voluntary wheel running
PO-131 Impact of short-term inhibition of PKA in Nucleus Accumbens on voluntary wheel running Open
Objective Based upon a Booth lab goal of establishing molecular regulators of physical activity motivation, my current study focuses on the effects of short-term inhibition of protein kinase A (PKA) activity in the nucleus accumbens (NAc).…
View article: Correction to: Overexpression of Protein Kinase Inhibitor Alpha Reverses Rat Low Voluntary Running Behavior
Correction to: Overexpression of Protein Kinase Inhibitor Alpha Reverses Rat Low Voluntary Running Behavior Open
View article: Voluntary wheel running improves adipose tissue immunometabolism in ovariectomized low-fit rats
Voluntary wheel running improves adipose tissue immunometabolism in ovariectomized low-fit rats Open
Loss of ovarian hormones is associated with increased adiposity, white adipose tissue (WAT) inflammation, and insulin resistance (IR). Previous work demonstrated ovariectomized (OVX) rats bred for high aerobic fitness (HCR) are protected a…
View article: Biological/Genetic Regulation of Physical Activity Level
Biological/Genetic Regulation of Physical Activity Level Open
Future research on physical activity regulation should incorporate genetics and other biological determinants of physical activity instead of a sole reliance on social and other environmental determinants.
View article: High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine
High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine Open
Pediatric obesity and nonalcoholic steatohepatitis (NASH) are on the rise in industrialized countries, yet our ability to mechanistically examine this relationship is limited by the lack of a suitable higher animal models. Here, we examine…
View article: Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms
Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms Open
This review proposes that physical inactivity could be considered a behavior selected by evolution for resting, and also selected to be reinforcing in life-threatening situations in which exercise would be dangerous. Underlying the notion …
View article: 5‐Aminoimidazole‐4‐carboxamide ribonucleotide prevents fat gain following the cessation of voluntary physical activity
5‐Aminoimidazole‐4‐carboxamide ribonucleotide prevents fat gain following the cessation of voluntary physical activity Open
New Findings What is the central question of this study? We investigated whether 5‐aminoimidazole‐4‐carboxamide‐1‐beta‐D‐ribofuranoside (AICAR) could prevent acute increases in body fat and changes in omental and subcutaneous adipose tissu…
View article: Sex determines effect of physical activity on diet preference: Association of striatal opioids and gut microbiota composition
Sex determines effect of physical activity on diet preference: Association of striatal opioids and gut microbiota composition Open
View article: Running from Disease: Molecular Mechanisms Associating Dopamine and Leptin Signaling in the Brain with Physical Inactivity, Obesity, and Type 2 Diabetes
Running from Disease: Molecular Mechanisms Associating Dopamine and Leptin Signaling in the Brain with Physical Inactivity, Obesity, and Type 2 Diabetes Open
Physical inactivity is a primary contributor to diseases such as obesity, cardiovascular disease, and type 2 diabetes. Accelerometry data suggest that a majority of US adults fail to perform substantial levels of physical activity needed t…
View article: Health Benefits of Exercise
Health Benefits of Exercise Open
Overwhelming evidence exists that lifelong exercise is associated with a longer health span, delaying the onset of 40 chronic conditions/diseases. What is beginning to be learned is the molecular mechanisms by which exercise sustains and i…
View article: Voluntary Running Attenuates Metabolic Dysfunction in Ovariectomized Low-Fit Rats
Voluntary Running Attenuates Metabolic Dysfunction in Ovariectomized Low-Fit Rats Open
Despite a fivefold difference in running volume between rat lines, EX similarly improved systemic insulin sensitivity, resting energy expenditure, and skeletal muscle mitochondrial content and adenosine monophosphate-activated protein kina…
View article: Daily exercise prevents diastolic dysfunction and oxidative stress in a female mouse model of western diet induced obesity by maintaining cardiac heme oxygenase-1 levels
Daily exercise prevents diastolic dysfunction and oxidative stress in a female mouse model of western diet induced obesity by maintaining cardiac heme oxygenase-1 levels Open
View article: Regular Exercise Reduces Endothelial Cortical Stiffness in Western Diet–Fed Female Mice
Regular Exercise Reduces Endothelial Cortical Stiffness in Western Diet–Fed Female Mice Open
We recently showed that Western diet–induced obesity and insulin resistance promotes endothelial cortical stiffness in young female mice. Herein, we tested the hypothesis that regular aerobic exercise would attenuate the development of end…
View article: Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running
Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running Open
View article: Loss of Cdk5 function in the nucleus accumbens decreases wheel running and may mediate age‐related declines in voluntary physical activity
Loss of Cdk5 function in the nucleus accumbens decreases wheel running and may mediate age‐related declines in voluntary physical activity Open
Key points Physical inactivity, which drastically increases with advancing age, is associated with numerous chronic diseases. The nucleus accumbens (the pleasure and reward ‘hub’ in the brain) influences wheel running behaviour in rodents.…
View article: Effects of intrinsic aerobic capacity and ovariectomy on voluntary wheel running and nucleus accumbens dopamine receptor gene expression
Effects of intrinsic aerobic capacity and ovariectomy on voluntary wheel running and nucleus accumbens dopamine receptor gene expression Open
View article: Exercise Has a Bone to Pick with Skeletal Muscle
Exercise Has a Bone to Pick with Skeletal Muscle Open
View article: Aerobic exercise training in the treatment of non‐alcoholic fatty liver disease related fibrosis
Aerobic exercise training in the treatment of non‐alcoholic fatty liver disease related fibrosis Open
Key points Physiologically relevant rodent models of non‐alcoholic steatohepatitis (NASH) that resemble the human condition are limited. Exercise training and energy restriction are first‐line recommendations for the treatment of NASH. Hyp…